Phenotype: increased mean corpuscular hemoglobin concentration

Definition
greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices
Synonyms
high mean corpuscular hemoglobin concentration,  increased MCHC,  increased mean corpuscular haemoglobin concentration,  high MCHC,  high mean corpuscular haemoglobin concentration
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased mean corpuscular hemoglobin concentration

Total number of significant genotype-phenotype associations: 57

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | EuroPhenome 0.00
Prdm2
Prdm2em1(IMPC)Marc
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 5.64×10-37
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 1.52×10-10
Skida1
Skida1tm1(KOMP)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration WTSI | IMPC 1.91×10-10
Bbc3
Bbc3em1(IMPC)Marc
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 1.05×10-08
Tmem94
Tmem94tm1a(EUCOMM)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | MGP 3.68×10-08
Zfp536
Zfp536tm1.1(KOMP)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 4.65×10-08
Cops4
Cops4tm1a(EUCOMM)Hmgu
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | MGP 6.55×10-07
Hsf2bp
Hsf2bptm1a(EUCOMM)Hmgu
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 7.77×10-07
Atp8a1
Atp8a1tm1a(EUCOMM)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 9.74×10-07
Diaph3
Diaph3tm1b(KOMP)Mbp
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 1.32×10-06
Usp31
Usp31em1(IMPC)Marc
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 2.88×10-06
Apoe
Apoetm1Unc
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin WTSI | EuroPhenome 1.07×10-05
Rab36
Rab36tm1b(KOMP)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 1.73×10-05
Tfr2
Tfr2em1(IMPC)Rbrc
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration RBRC | IMPC 1.84×10-05
Dnajc10
Dnajc10tm1a(EUCOMM)Hmgu
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 1.96×10-05
Fndc4
Fndc4tm1.1(KOMP)Vlcg
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 2.66×10-05
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration WTSI | IMPC 2.80×10-05
Hint1
Hint1tm1a(EUCOMM)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 2.98×10-05
Usp19
Usp19tm1b(EUCOMM)Hmgu
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration WTSI | IMPC 3.04×10-05
Sox13
Sox13tm1a(EUCOMM)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | MGP 3.29×10-05
Slc38a10
Slc38a10tm2a(EUCOMM)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin ICS | MGP 3.51×10-05
Asxl1
Asxl1tm1a(EUCOMM)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 3.53×10-05
Ahrr
Ahrrtm1b(KOMP)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 3.64×10-05
Washc5
Washc5tm1a(EUCOMM)Hmgu
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin HMGU | EuroPhenome 3.78×10-05
Sirt6
Sirt6tm1a(EUCOMM)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 3.79×10-05
Snap23
Snap23tm1b(EUCOMM)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MRC Harwell | IMPC 4.07×10-05
Ahrr
Ahrrtm1b(KOMP)Wtsi
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration JAX | IMPC 4.60×10-05
Slc6a5
Slc6a5tm1.1(KOMP)Vlcg
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration UC Davis | IMPC 4.97×10-05
Rprd1b
Rprd1btm1a(EUCOMM)Hmgu
HET postnatal increased mean corpuscular hemoglobin concentration Haematology | Mean corpuscular haemoglobin MRC Harwell | EuroPhenome 6.06×10-05
Usp45
Usp45em1(IMPC)Marc
HOM postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MARC | IMPC 7.70×10-05
Fgf9
Fgf9tm1b(KOMP)Wtsi
HET postnatal increased mean corpuscular hemoglobin concentration Hematology | Mean cell hemoglobin concentration MRC Harwell | IMPC 9.67×10-05

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 The way we measure

 Phenotype associations stats

0.82% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased mean corpuscular hemoglobin concentration (31/3799)

0.69% females (26/3767) 0.77% males (29/3777)

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