Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with increased cardiac muscle contractility
Total number of significant genotype-phenotype associations: 15
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Procedure | Parameter | Phenotyping Center | Source | P Value | |
|---|---|---|---|---|---|---|---|---|
| Ap4e1 Ap4e1tm1b(KOMP)Wtsi |
HOM | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | HMGU | IMPC | 9.03×10-06 | ||
| Avpi1 Avpi1tm1b(EUCOMM)Hmgu |
HOM | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | HMGU | IMPC | 2.76×10-05 | ||
| Tfap2b Tfap2btm1b(EUCOMM)Wtsi |
HET | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | HMGU | IMPC | 3.16×10-05 | ||
| Zfp235 Zfp235tm1b(KOMP)Wtsi |
HOM | Early adult | increased cardiac muscle contractility | Echo | Fractional Shortening | BCM | IMPC | 3.87×10-05 | ||
| Fzd8 Fzd8em1(IMPC)Bay |
HOM | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | BCM | IMPC | 4.81×10-05 | ||
| Csnk1g2 Csnk1g2tm1b(EUCOMM)Wtsi |
HOM | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | HMGU | IMPC | 4.99×10-05 | ||
| Aoc1 Aoc1tm1b(EUCOMM)Hmgu |
HOM | Early adult | increased cardiac muscle contractility | Echo | Fractional Shortening | HMGU | IMPC | 5.98×10-05 | ||
| Sdc2 Sdc2tm1b(KOMP)Wtsi |
HOM | Early adult | increased cardiac muscle contractility | Echo | Ejection Fraction | HMGU | IMPC | 7.04×10-05 | ||
| Yae1d1 Yae1d1tm1b(EUCOMM)Hmgu |
HET | Early adult | increased cardiac muscle contractility | Echo | Fractional Shortening | HMGU | IMPC | 8.15×10-05 |