Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
increased cardiac muscle contraction
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 23

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
0.00
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
MRC Harwell
IMPC
8.95×10-09
Calb1
Calb1em1(IMPC)Ccpcz
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
CCP-IMG
IMPC
8.98×10-07
Cenpv
Cenpvem1(IMPC)Hmgu
HOM   Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.61×10-06
Myof
Myoftm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
2.04×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
9.05×10-06
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.05×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.10×10-05
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET   Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
1.16×10-05
Lmo1
Lmo1tm1b(KOMP)Mbp
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
3.09×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
BCM
IMPC
3.34×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Late adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
3.37×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
3.63×10-05
Tfap2b
Tfap2btm1b(EUCOMM)Wtsi
HET Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
3.69×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
BCM
IMPC
4.20×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
6.22×10-05
Anpep
Anpepem1(IMPC)Hmgu
HOM   Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
6.74×10-05
Sdc2
Sdc2tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo
HMGU
IMPC
7.21×10-05
Asb7
Asb7em1(IMPC)Ccpcz
HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo
CCP-IMG
IMPC
7.25×10-05
Gzmk
Gzmktm1b(KOMP)Wtsi
HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
8.10×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Fractional Shortening
Echo
HMGU
IMPC
8.22×10-05
Sorl1
Sorl1tm1a(EUCOMM)Wtsi
HOM Late adult increased cardiac muscle contractility Fractional Shortening
Echo
ICS
IMPC
9.21×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.21% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (22/1811)

0.39% females (7/1785) 0.73% males (11/1509)

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