Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 15

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 9.03×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.76×10-05
Tfap2b
Tfap2btm1b(EUCOMM)Wtsi
HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 3.16×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening BCM | IMPC 3.87×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction BCM | IMPC 4.81×10-05
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 4.99×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 5.98×10-05
Sdc2
Sdc2tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.04×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 8.15×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

0.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (9/1597)

0.00% females (0/1548) 0.70% males (9/1285)

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