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Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
increased cardiac muscle contraction
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Mpp3
Mpp3tm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 MRC Harwell
IMPC		 1.23×10-11
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 MRC Harwell
IMPC		 9.43×10-10
Baiap2l2
Baiap2l2tm1a(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 ICS
IMPC		 4.75×10-07
Prss48
Prss48em1(IMPC)Ccpcz 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 1.10×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo		 HMGU
IMPC		 1.19×10-06
Calb1
Calb1em1(IMPC)Ccpcz 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 1.34×10-06
Bms1
Bms1tm1b(EUCOMM)Hmgu 		HET   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 HMGU
IMPC		 7.68×10-06
Ccr2
Ccr2em1(IMPC)H 		HOM Late adult increased cardiac muscle contractility Fractional Shortening
Echo		 MRC Harwell
IMPC		 1.24×10-05
Avpi1
Avpi1tm1b(EUCOMM)Hmgu 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 HMGU
IMPC		 1.34×10-05
Izumo2
Izumo2em1(IMPC)Bay 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 BCM
IMPC		 2.10×10-05
4933430I17Rik
4933430I17Riktm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 ICS
IMPC		 2.26×10-05
Pard3b
Pard3btm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 HMGU
IMPC		 2.50×10-05
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 HMGU
IMPC		 2.62×10-05
Abitram
Abitramtm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 BCM
IMPC		 2.62×10-05
Tincr
Tincrem1(IMPC)Ccpcz 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 3.04×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 4.41×10-05
Asb7
Asb7em1(IMPC)Ccpcz 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 4.74×10-05
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 BCM
IMPC		 4.84×10-05
Sall3
Sall3tm1.1(KOMP)Mbp 		HET Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 CCP-IMG
IMPC		 4.91×10-05
Anpep
Anpepem1(IMPC)Hmgu 		HOM   Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 HMGU
IMPC		 5.29×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi 		HET   Late adult increased cardiac muscle contractility Fractional Shortening
Echo		 ICS
IMPC		 5.81×10-05
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 ICS
IMPC		 6.26×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 BCM
IMPC		 7.86×10-05
Cdc26
Cdc26tm1b(EUCOMM)Hmgu 		HET Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 ICS
IMPC		 8.44×10-05
Hectd3
Hectd3tm1(NCOM)Cmhd 		HOM Early adult increased cardiac muscle contractility Fractional Shortening
Echo		 MARC
IMPC		 8.53×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Ejection Fraction
Echo		 MRC Harwell
IMPC		 9.87×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.18% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (26/2202)

0.50% females (11/2188) 0.47% males (9/1909)

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