Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
increased cardiac muscle contraction
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM   Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 0.00
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction MRC Harwell | IMPC 7.85×10-09
Pax5
Pax5tm1b(EUCOMM)Wtsi
HET   Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.97×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 4.81×10-06
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 9.87×10-06
Lmo1
Lmo1tm1b(KOMP)Mbp
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 1.07×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.32×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 3.63×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening BCM | IMPC 3.87×10-05
Asb7
Asb7em1(IMPC)Ccpcz
HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening CCP-IMG | IMPC 3.88×10-05
Fdx1
Fdx1tm1b(EUCOMM)Wtsi
HET   Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 4.78×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction BCM | IMPC 4.81×10-05
Sdc2
Sdc2tm1b(KOMP)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.04×10-05
Slc2a5
Slc2a5tm1b(EUCOMM)Wtsi
HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 7.80×10-05
Tfap2b
Tfap2btm1b(EUCOMM)Wtsi
HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.89×10-05
Gzmk
Gzmktm1b(KOMP)Wtsi
HOM   Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 8.11×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 8.30×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.03% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (17/1653)

0.25% females (4/1632) 0.74% males (10/1359)

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