banner
Genes Phenotypes

Phenotype: increased cardiac muscle contractility

Definition
greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
Synonyms
increased cardiac muscle contraction
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased cardiac muscle contractility

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 0.00
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction MRC Harwell | IMPC 7.85×10-09
Pax5
Pax5tm1b(EUCOMM)Wtsi 		HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.97×10-06
Avpi1
Avpi1tm1b(EUCOMM)Hmgu 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 4.81×10-06
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 9.87×10-06
Lmo1
Lmo1tm1b(KOMP)Mbp 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 1.07×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 2.32×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu 		HET Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 3.63×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening BCM | IMPC 3.87×10-05
Asb7
Asb7em1(IMPC)Ccpcz 		HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening CCP-IMG | IMPC 3.88×10-05
Fdx1
Fdx1tm1b(EUCOMM)Wtsi 		HET Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 4.78×10-05
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction BCM | IMPC 4.81×10-05
Sdc2
Sdc2tm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.04×10-05
Slc2a5
Slc2a5tm1b(EUCOMM)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening HMGU | IMPC 7.80×10-05
Tfap2b
Tfap2btm1b(EUCOMM)Wtsi 		HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 7.89×10-05
Gzmk
Gzmktm1b(KOMP)Wtsi 		HOM Early adult increased cardiac muscle contractility Echo | Fractional Shortening ICS | IMPC 8.11×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET Early adult increased cardiac muscle contractility Echo | Ejection Fraction HMGU | IMPC 8.30×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.03% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac muscle contractility (17/1653)

0.25% females (4/1632) 0.74% males (10/1359)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter