Phenotype: decreased heart rate

Definition
fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
bradycardia,  bradyrhythmia,  reduced heart rate
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 116

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Creg2
Creg2em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 4.16×10-10
Atp2b3
Atp2b3em1(IMPC)J
HOM   Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 5.93×10-10
Creg2
Creg2em1(IMPC)J
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.68×10-09
Trh
Trhem1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.06×10-08
Six1
Six1em1(IMPC)Mbp
HET Late adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.13×10-08
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.87×10-08
Atp2b3
Atp2b3em1(IMPC)J
HOM   Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.14×10-08
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.34×10-08
Hcn1
Hcn1em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 6.78×10-08
Atp7a
Atp7aem1(IMPC)J
HOM   Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 7.21×10-08
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 1.25×10-07
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.29×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.61×10-07
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 1.77×10-07
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.80×10-07
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Echo | HR HMGU | IMPC 3.08×10-07
Ist1
Ist1em1(IMPC)J
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 4.09×10-07
Nfix
Nfixem6(IMPC)H
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.23×10-07
Pycrl
Pycrlem1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 4.67×10-07
Bmx
Bmxtm1b(EUCOMM)Wtsi
HEM   Early adult decreased heart rate Echo | HR ICS | IMPC 5.39×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 6.12×10-07
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 6.49×10-07
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.56×10-07
Ssc4d
Ssc4dem1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 8.60×10-07
Trh
Trhem1(IMPC)Tcp
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 1.26×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.30×10-06
Tmem203
Tmem203em1(IMPC)H
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.41×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.42×10-06
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Late adult prolonged RR interval Electrocardiogram (ECG) | RR ICS | IMPC 1.61×10-06
Ano3
Ano3em2(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.04×10-06
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.23×10-06
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.24×10-06
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 2.34×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 2.35×10-06
P3h1
P3h1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.48×10-06
Ist1
Ist1em1(IMPC)J
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.48×10-06
Setbp1
Setbp1tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 2.48×10-06
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.50×10-06
Ano3
Ano3em2(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.57×10-06
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Late adult decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 3.60×10-06
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 3.64×10-06
Pde2a
Pde2aem1(IMPC)H
HET   Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 4.11×10-06
Cisd1
Cisd1em1(IMPC)Hmgu
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 4.38×10-06
Six1
Six1em1(IMPC)Mbp
HET Late adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.72×10-06
Tat
Tatem1(IMPC)J
HOM Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.72×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 5.18×10-06
Klk4
Klk4tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 5.28×10-06
Pycrl
Pycrlem1(IMPC)J
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.72×10-06
Pde2a
Pde2aem1(IMPC)H
HET   Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.25×10-06
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 6.33×10-06
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 6.47×10-06
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Late adult decreased heart rate Electrocardiogram (ECG) | HR ICS | IMPC 7.15×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 8.46×10-06
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 8.63×10-06
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 9.10×10-06
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 9.18×10-06
Try10
Try10em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 9.81×10-06
Spock1
Spock1em1(IMPC)H
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.01×10-05
Cisd1
Cisd1em1(IMPC)Hmgu
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.31×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.33×10-05
Atp7a
Atp7aem1(IMPC)J
HOM   Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.34×10-05
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.37×10-05
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.41×10-05
Tbc1d24
Tbc1d24tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 1.62×10-05
Try10
Try10em1(IMPC)J
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.63×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi
HOM   Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 1.68×10-05
Nbr1
Nbr1tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate Echo | HR MRC Harwell | IMPC 1.76×10-05
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.82×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR CCP-IMG | IMPC 1.83×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.92×10-05
Gabra2
Gabra2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.09×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.12×10-05
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.13×10-05
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.18×10-05
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.20×10-05
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.25×10-05
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 2.31×10-05
Zfp593
Zfp593em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 2.51×10-05
Rps6kc1
Rps6kc1tm1b(EUCOMM)Wtsi
HOM   Early adult decreased heart rate Echo | HR BCM | IMPC 2.80×10-05
Gabra2
Gabra2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.82×10-05
Vgf
Vgfem1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.92×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.99×10-05
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 3.12×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 3.41×10-05
Dpf3
Dpf3em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 3.43×10-05
Anks1
Anks1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 3.60×10-05
Pcm1
Pcm1em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 3.69×10-05
Ctdspl2
Ctdspl2tm2b(KOMP)Wtsi
HET Early adult decreased heart rate Echo | HR BCM | IMPC 3.71×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.74×10-05
Klk4
Klk4tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.82×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR TCP | IMPC 4.08×10-05
Fbxw9
Fbxw9tm1a(EUCOMM)Wtsi
HET   Early adult decreased heart rate Echo | HR BCM | IMPC 4.12×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 4.14×10-05
Tat
Tatem1(IMPC)J
HOM Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 5.00×10-05
Tmem203
Tmem203em1(IMPC)H
HOM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 5.28×10-05
P4ha3
P4ha3em1(IMPC)J
HOM   Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 5.41×10-05
Grp
Grpem1(IMPC)H
HOM   Late adult decreased heart rate Echo | HR MRC Harwell | IMPC 5.62×10-05
Oplah
Oplahtm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR HMGU | IMPC 5.90×10-05
Tex2
Tex2em1(IMPC)J
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 6.33×10-05
Smo
Smotm1b(KOMP)Wtsi
HET   Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 6.69×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 7.40×10-05
Zfp593
Zfp593em1(IMPC)J
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.53×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 7.91×10-05
Pak2
Pak2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 8.04×10-05
Ubap2l
Ubap2lem1(IMPC)Bay
HET   Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.14×10-05
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Late adult prolonged RR interval Electrocardiogram (ECG) | RR ICS | IMPC 8.29×10-05
Dnajb14
Dnajb14em1(IMPC)J
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 8.31×10-05
P3h2
P3h2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 9.36×10-05
Maged1
Maged1em1(IMPC)Mbp
HEM   Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 9.72×10-05
Bri3
Bri3em1(IMPC)Bay
HOM   Early adult decreased heart rate Echo | HR BCM | IMPC 9.81×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.31% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (70/5350)

0.47% females (24/5151) 0.64% males (32/4969)

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