Phenotype: decreased heart rate

Definition
fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
bradycardia,  bradyrhythmia,  reduced heart rate
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 131

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Dennd5b
Dennd5bem1(IMPC)Tcp
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
1.88×10-16
Dennd5b
Dennd5bem1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
1.80×10-15
Atp2b3
Atp2b3em1(IMPC)J
HOM   Late adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
4.75×10-10
Creg2
Creg2em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
2.95×10-09
Creg2
Creg2em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
9.56×10-09
Atp2b3
Atp2b3em1(IMPC)J
HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
5.34×10-08
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
1.15×10-07
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
HMGU
IMPC
1.21×10-07
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
1.34×10-07
Atp7a
Atp7aem1(IMPC)J
HOM   Late adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.40×10-07
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.59×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.07×10-07
Hcn1
Hcn1em1(IMPC)H
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.24×10-07
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
ICS
IMPC
2.44×10-07
Slc6a6
Slc6a6em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.59×10-07
Six1
Six1em1(IMPC)Mbp
HET Late adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
2.64×10-07
Try10
Try10em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.85×10-07
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate HR
Echo
HMGU
IMPC
3.66×10-07
Gabra2
Gabra2em1(IMPC)H
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.21×10-07
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
5.25×10-07
Bmx
Bmxtm1b(EUCOMM)Wtsi
HEM   Early adult decreased heart rate HR
Echo
ICS
IMPC
5.39×10-07
Nfix
Nfixem6(IMPC)H
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
5.68×10-07
Try10
Try10em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
6.65×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
6.92×10-07
Slc6a6
Slc6a6em1(IMPC)Mbp
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
7.28×10-07
Smarcc2
Smarcc2em1(IMPC)J
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
8.23×10-07
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.04×10-06
Ldhal6b
Ldhal6bem1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.12×10-06
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.50×10-06
Ist1
Ist1em1(IMPC)J
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.61×10-06
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
1.64×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.70×10-06
Tat
Tatem1(IMPC)J
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.94×10-06
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
ICS
IMPC
2.08×10-06
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Echo
BCM
IMPC
2.25×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Echo
BCM
IMPC
2.36×10-06
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
HMGU
IMPC
2.39×10-06
Ssc4d
Ssc4dem1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
2.48×10-06
Setbp1
Setbp1tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart rate HR
Electrocardiogram (ECG)
ICS
IMPC
2.48×10-06
Six1
Six1em1(IMPC)Mbp
HET Late adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.64×10-06
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
CCP-IMG
IMPC
2.90×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.72×10-06
Cisd1
Cisd1em1(IMPC)Hmgu
HOM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
HMGU
IMPC
3.90×10-06
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
4.28×10-06
Smarcc2
Smarcc2em1(IMPC)J
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
4.68×10-06
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
BCM
IMPC
4.75×10-06
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart rate HR
Electrocardiogram (ECG)
BCM
IMPC
6.33×10-06
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
HMGU
IMPC
8.72×10-06
Tpx2
Tpx2em1(IMPC)J
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
8.74×10-06
Gria1
Gria1em1(IMPC)H
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.43×10-06
Ist1
Ist1em1(IMPC)J
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
9.63×10-06
Dhrs4
Dhrs4em1(IMPC)Hmgu
HOM Early adult decreased heart rate HR
Echo
HMGU
IMPC
9.76×10-06
Iffo2
Iffo2em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.00×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.04×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
CCP-IMG
IMPC
1.07×10-05
Cisd1
Cisd1em1(IMPC)Hmgu
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
1.11×10-05
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
1.16×10-05
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.22×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi
HOM   Late adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.33×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
1.34×10-05
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
1.34×10-05
Tmem203
Tmem203em1(IMPC)H
HOM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.43×10-05
Tat
Tatem1(IMPC)J
HOM Late adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
1.49×10-05
Rbm20
Rbm20em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.50×10-05
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.55×10-05
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
BCM
IMPC
1.60×10-05
Tbc1d24
Tbc1d24tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate HR
Echo
BCM
IMPC
1.62×10-05
Fam160a2
Fam160a2em1(IMPC)Tcp
HOM   Late adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
1.64×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
1.69×10-05
Pde2a
Pde2aem1(IMPC)H
HET   Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.71×10-05
Pde2a
Pde2aem1(IMPC)H
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.71×10-05
Atp7a
Atp7aem1(IMPC)J
HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.76×10-05
Nbr1
Nbr1tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate HR
Echo
MRC Harwell
IMPC
1.76×10-05
Gabra2
Gabra2em1(IMPC)H
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.09×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
2.12×10-05
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
2.17×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.47×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
2.82×10-05
Ldhal6b
Ldhal6bem1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.85×10-05
Tex21
Tex21em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
2.86×10-05
Rps6kc1
Rps6kc1tm1b(EUCOMM)Wtsi
HOM   Early adult decreased heart rate HR
Echo
BCM
IMPC
3.07×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
3.09×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
3.19×10-05
P4ha3
P4ha3em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
3.44×10-05
Stx6
Stx6em1(IMPC)H
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.45×10-05
Cand1
Cand1em1(IMPC)Mbp
HET Late adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
3.55×10-05
Maged1
Maged1em1(IMPC)Mbp
HEM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
3.61×10-05
Anks1
Anks1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Echo
BCM
IMPC
3.70×10-05
Ctdspl2
Ctdspl2tm2b(KOMP)Wtsi
HET Early adult decreased heart rate HR
Echo
BCM
IMPC
3.70×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
3.75×10-05
Atp8b1
Atp8b1em1(IMPC)Tcp
HOM Late adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
3.89×10-05
Iffo2
Iffo2em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
3.90×10-05
Xpo5
Xpo5em1(IMPC)Mbp
HET   Late adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
3.92×10-05
Fbxw9
Fbxw9tm1a(EUCOMM)Wtsi
HET   Early adult decreased heart rate HR
Echo
BCM
IMPC
4.12×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
4.16×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
HMGU
IMPC
4.27×10-05
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
4.30×10-05
Cdc5l
Cdc5lem1(IMPC)J
HET Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
4.36×10-05
Tpx2
Tpx2em1(IMPC)J
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
4.68×10-05
Pycrl
Pycrlem1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
4.71×10-05
Ubap2l
Ubap2lem1(IMPC)Bay
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
4.75×10-05
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.79×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
5.58×10-05
Grp
Grpem1(IMPC)H
HOM   Late adult decreased heart rate HR
Echo
MRC Harwell
IMPC
5.62×10-05
Oplah
Oplahtm1b(KOMP)Wtsi
HOM Early adult decreased heart rate HR
Echo
HMGU
IMPC
5.94×10-05
Gabre
Gabreem1(IMPC)H
HEM   Late adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
6.30×10-05
Gm5127
Gm5127em1(IMPC)J
HEM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
6.43×10-05
Smo
Smotm1b(KOMP)Wtsi
HET   Early adult decreased heart rate HR
Electrocardiogram (ECG)
BCM
IMPC
6.69×10-05
Tex2
Tex2em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
6.76×10-05
Pcm1
Pcm1em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
6.79×10-05
Zbtb37
Zbtb37em1(IMPC)J
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
JAX
IMPC
7.24×10-05
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
7.39×10-05
Maged1
Maged1em1(IMPC)Mbp
HEM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
7.39×10-05
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi
HOM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
TCP
IMPC
7.73×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM   Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
7.82×10-05
Gria1
Gria1em1(IMPC)H
HOM Late adult decreased heart rate HR
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.83×10-05
Tpgs2
Tpgs2tm1.1(KOMP)Vlcg
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
7.91×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
BCM
IMPC
7.91×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate HR
Electrocardiogram (ECG)
UC Davis
IMPC
7.93×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
8.39×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
9.05×10-05
Bri3
Bri3em1(IMPC)Bay
HOM   Early adult decreased heart rate HR
Echo
BCM
IMPC
9.81×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.36% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (79/5830)

0.43% females (24/5618) 0.72% males (39/5434)

Select a parameter    



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