Phenotype: decreased heart rate

Definition
fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
bradyrhythmia,  reduced heart rate,  bradycardia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 85

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Hcn1
Hcn1em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 6.26×10-11
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.72×10-10
Trh
Trhem1(IMPC)Tcp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.41×10-09
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 1.91×10-08
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.14×10-07
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.21×10-07
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 1.23×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.46×10-06
Gabra2
Gabra2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.72×10-06
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.80×10-06
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 3.41×10-06
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 4.86×10-06
Spock1
Spock1em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.23×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Echo | HR BCM | IMPC 6.58×10-06
Il18r1
Il18r1em1(IMPC)Mbp
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 8.55×10-06
Tmem203
Tmem203em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 8.75×10-06
Vgf
Vgfem1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 8.82×10-06
Gcsh
Gcshem1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 8.93×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 9.49×10-06
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 9.85×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.02×10-05
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.02×10-05
Got1
Got1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.04×10-05
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.29×10-05
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Echo | HR HMGU | IMPC 1.30×10-05
Mindy2
Mindy2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.36×10-05
Atp2b3
Atp2b3em1(IMPC)J
HOM Late adult decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 1.42×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR BCM | IMPC 1.48×10-05
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.71×10-05
Stk26
Stk26tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR CCP-IMG | IMPC 1.76×10-05
Gabra2
Gabra2em1(IMPC)H
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 1.91×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.42×10-05
Stk26
Stk26tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 2.64×10-05
Pak2
Pak2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.83×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 3.12×10-05
Tnip1
Tnip1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.69×10-05
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.70×10-05
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 4.80×10-05
Spock1
Spock1em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 5.10×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.28×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 5.51×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.73×10-05
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.88×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR CCP-IMG | IMPC 6.94×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 7.05×10-05
Wars
Warstm1b(EUCOMM)Hmgu
HET Early adult decreased heart rate Echo | HR HMGU | IMPC 7.12×10-05
Atp2b3
Atp2b3em1(IMPC)J
HOM Late adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.18×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 7.31×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.58×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.75×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 9.18×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 9.48×10-05
Gcsh
Gcshem1(IMPC)H
HET Early adult decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 9.56×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM Early adult decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 9.97×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.80% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (35/4392)

0.66% females (29/4371) 0.62% males (26/4199)

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