Phenotype: decreased heart rate

Definition
fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
Synonyms
bradyrhythmia,  reduced heart rate,  bradycardia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart rate

Total number of significant genotype-phenotype associations: 65

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 3.93×10-10
Trh
Trhem1(IMPC)Tcp
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 1.41×10-09
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 1.91×10-08
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.98×10-08
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR JAX | IMPC 1.78×10-07
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.02×10-07
Slc25a1
Slc25a1tm1b(EUCOMM)Wtsi
HET postnatal decreased heart rate Echo | HR BCM | IMPC 6.70×10-07
Gcsh
Gcshem1(IMPC)H
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.23×10-06
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM postnatal decreased heart rate Echo | HR HMGU | IMPC 1.31×10-06
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.95×10-06
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.72×10-06
Got1
Got1tm1b(EUCOMM)Hmgu
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.84×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 3.92×10-06
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 4.07×10-06
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 5.07×10-06
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 6.44×10-06
Tmem203
Tmem203em1(IMPC)H
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 8.32×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM postnatal decreased heart rate Echo | HR BCM | IMPC 1.00×10-05
Il18r1
Il18r1em1(IMPC)Mbp
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.30×10-05
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 1.67×10-05
Mindy2
Mindy2em1(IMPC)H
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.09×10-05
Vgf
Vgfem1(IMPC)H
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.33×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 2.38×10-05
Mindy2
Mindy2em1(IMPC)H
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 2.46×10-05
Gcsh
Gcshem1(IMPC)H
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 3.00×10-05
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 4.80×10-05
Stx1a
Stx1atm1b(EUCOMM)Hmgu
HOM postnatal decreased heart rate Echo | HR BCM | IMPC 5.27×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.28×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 5.51×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.63×10-05
Ift81
Ift81tm1b(EUCOMM)Wtsi
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 5.88×10-05
Got1
Got1tm1b(EUCOMM)Hmgu
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR MRC Harwell | IMPC 6.01×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 6.78×10-05
Wars
Warstm1b(EUCOMM)Hmgu
HET postnatal decreased heart rate Echo | HR HMGU | IMPC 7.12×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET postnatal decreased heart rate Electrocardiogram (ECG) | HR HMGU | IMPC 7.31×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.42×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.43×10-05
Stx1a
Stx1atm1b(EUCOMM)Hmgu
HOM postnatal prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.56×10-05
Rest
Resttm2b(EUCOMM)Wtsi
HET postnatal prolonged RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 9.18×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR UC Davis | IMPC 9.32×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM postnatal decreased heart rate Electrocardiogram (ECG) | HR TCP | IMPC 9.97×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart rate (26/3922)

0.56% females (22/3898) 0.54% males (20/3716)

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