Phenotype: abnormal QT variability

Definition
anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal QT variability

Total number of significant genotype-phenotype associations: 24

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Cacna2d4
Cacna2d4em1(IMPC)J
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 1.96×10-06
Col13a1
Col13a1tm1b(EUCOMM)Wtsi
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 4.34×10-06
Meis1
Meis1tm1b(EUCOMM)Hmgu
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 4.52×10-06
Rnf10
Rnf10em1(IMPC)J
HOM Late adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 1.08×10-05
Foxj3
Foxj3tm1a(EUCOMM)Wtsi
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 1.46×10-05
Scn2b
Scn2bem1(IMPC)Bay
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 1.65×10-05
Aldoa
Aldoatm1.1(KOMP)Wtsi
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 2.44×10-05
Cecr2
Cecr2tm2b(EUCOMM)Hmgu
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 2.48×10-05
Rsf1
Rsf1tm1b(EUCOMM)Wtsi
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 5.40×10-05
Ltbp2
Ltbp2tm2b(KOMP)Wtsi
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 6.48×10-05
Tubb4b
Tubb4bem1(IMPC)J
HET Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 6.52×10-05
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 7.69×10-05
Cd33
Cd33tm1.1(KOMP)Vlcg
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 8.00×10-05
Trh
Trhem1(IMPC)Tcp
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 8.99×10-05
Ptgr1
Ptgr1tm1b(EUCOMM)Wtsi
HOM Early adult abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 9.20×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QT variability (15/2568)

0.36% females (9/2526) 0.00% males (0/2515)

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