Phenotype: abnormal QT variability

Definition anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities

Synonyms abnormal QTVI

MP browserMP:0004156

Login to register interest

Phenotype associations stats

0.40% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QT variability (8/2024)

0.35% females (7/1981) 0.30% males (6/1989)



Gene variants with abnormal QT variability

Total number of significant genotype-phenotype associations: 13

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Foxj3
Foxj3tm1a(EUCOMM)Wtsi
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 2.68E-5
Car13
Car13tm1b(KOMP)Wtsi
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 3.22E-5
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 3.51E-5
Mapkap1
Mapkap1tm1a(EUCOMM)Wtsi
HET Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 3.64E-5
Slc13a5
Slc13a5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 6.56E-5
Aldoa
Aldoatm1.1(KOMP)Wtsi
HET Female postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 7.89E-5
Scn2b
Scn2bem1(IMPC)Bay
HOM Female postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 8.07E-5
Ust
Ustem1(IMPC)J
HET Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 9.54E-5

Download data as: TSV XLS