Phenotype: abnormal QT variability

Definition anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities

Synonyms abnormal QTVI

MP browserMP:0004156

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Phenotype associations stats

0.62% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QT variability (10/1611)

0.56% females (9/1610) 0.50% males (8/1608)



Gene variants with abnormal QT variability

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Osbpl11
Osbpl11tm1b(EUCOMM)Hmgu
HET Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 2.15E-18
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi
HET Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 1.31E-17
Marco
Marcotm2b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 2.59E-15
Klrb1
Klrb1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 5.22E-13
Wars
Warstm1b(EUCOMM)Hmgu
HET Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 1.06E-6
Ust
Ustem1J
HET Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 4.25E-5
Ust
Ustem1J
HOM Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 4.25E-5
Aldob
Aldobtm2b(EUCOMM)Wtsi
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 8.05E-5
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 8.15E-5
Aldoa
Aldoatm1.1(KOMP)Wtsi
HET Female postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 8.33E-5
Cecr2
Cecr2tm2b(EUCOMM)Hmgu
HET Female postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 9.07E-5

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