Phenotype: abnormal QT variability

Definition anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities

Synonyms abnormal QTVI

MP browserMP:0004156

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Phenotype associations stats

0.26% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal QT variability (5/1949)

0.21% females (4/1906) 0.21% males (4/1915)



Gene variants with abnormal QT variability

Total number of significant genotype-phenotype associations: 8

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Car13
Car13tm1b(KOMP)Wtsi
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 2.69E-5
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion TCP | IMPC 3.57E-5
Slc13a5
Slc13a5tm1b(EUCOMM)Hmgu
HOM Female Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion HMGU | IMPC 6.56E-5
Ust
Ustem1(IMPC)J
HET Male postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion JAX | IMPC 7.82E-5
Aldoa
Aldoatm1.1(KOMP)Wtsi
HET Female postnatal abnormal QT variability Electrocardiogram (ECG) | QTc Dispersion BCM | IMPC 8.15E-5

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