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Phenotype: abnormal sinus arrhythmia

Definition
any anomaly in the normal phenomenon of mild acceleration and slowing of the heart rate that occurs during the respiratory cycle
Synonyms
abnormal respiratory sinus arrythmia,  abnormal RSA,  abnormal SA
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal sinus arrhythmia

Total number of significant genotype-phenotype associations: 67

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 HMGU
IMPC		 1.46×10-25
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 4.91×10-24
Ndufa8
Ndufa8tm1b(EUCOMM)Hmgu 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 7.72×10-20
Elmod1
Elmod1tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.66×10-15
Casq2
Casq2tm1b(KOMP)Wtsi 		HET Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 8.44×10-10
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 BCM
IMPC		 2.76×10-09
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 3.05×10-09
Sirt1
Sirt1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 8.74×10-09
Cox6b1
Cox6b1em1(IMPC)Tcp 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 1.13×10-08
Chst5
Chst5tm1b(EUCOMM)Wtsi 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.24×10-08
Chd2
Chd2tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 2.07×10-08
Atp6v1d
Atp6v1dtm1b(EUCOMM)Hmgu 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 4.85×10-08
Avpi1
Avpi1tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 8.05×10-08
Tmtc3
Tmtc3tm1b(EUCOMM)Wtsi 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 8.87×10-08
Galk2
Galk2tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.60×10-07
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 1.61×10-07
Scarb2
Scarb2em2(IMPC)Tcp 		HOM   Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 1.78×10-07
Hipk3
Hipk3tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.80×10-07
Atn1
Atn1tm1b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.86×10-07
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 4.19×10-07
Csnk1g2
Csnk1g2tm1b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 4.52×10-07
Arrb2
Arrb2tm1.1(KOMP)Vlcg 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 JAX
IMPC		 5.88×10-07
Casq2
Casq2tm1b(KOMP)Wtsi 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 6.01×10-07
Arrb2
Arrb2tm1.1(KOMP)Vlcg 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 7.41×10-07
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.38×10-06
Decr2
Decr2tm1b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.65×10-06
Pcyox1l
Pcyox1lem1(IMPC)J 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 1.97×10-06
Srsf11
Srsf11tm1b(EUCOMM)Wtsi 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 2.55×10-06
Ywhaz
Ywhaztm1b(EUCOMM)Hmgu 		HET   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 2.58×10-06
Egln3
Egln3tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 BCM
IMPC		 3.07×10-06
Bach1
Bach1tm1.1(KOMP)Vlcg 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 JAX
IMPC		 3.11×10-06
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 3.28×10-06
Med20
Med20em1(IMPC)J 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 4.46×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 4.82×10-06
Scarb2
Scarb2em2(IMPC)Tcp 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 6.21×10-06
Cdc20
Cdc20tm1.1(KOMP)Vlcg 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 7.46×10-06
Paox
Paoxtm1.1(KOMP)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 1.08×10-05
Calhm6
Calhm6tm2b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 1.09×10-05
Ucp1
Ucp1tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 HMGU
IMPC		 1.16×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 1.45×10-05
Tlr13
Tlr13tm1.1(KOMP)Vlcg 		HEM   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 HMGU
IMPC		 1.74×10-05
Foxj3
Foxj3tm1a(EUCOMM)Wtsi 		HET   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 BCM
IMPC		 2.52×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 JAX
IMPC		 2.58×10-05
Atp6v1d
Atp6v1dtm1b(EUCOMM)Hmgu 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 2.63×10-05
Hdac1
Hdac1tm1b(EUCOMM)Wtsi 		HET   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 2.86×10-05
Smo
Smotm1b(KOMP)Wtsi 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 2.94×10-05
Colca2
Colca2tm1b(NCOM)Mfgc 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 3.34×10-05
Vax1
Vax1tm1b(KOMP)Mbp 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 3.50×10-05
Atn1
Atn1tm1b(EUCOMM)Wtsi 		HOM   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.89×10-05
Psph
Psphtm1.1(KOMP)Vlcg 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 4.96×10-05
Gpc2
Gpc2tm1.1(KOMP)Vlcg 		HOM   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 5.02×10-05
Rptor
Rptortm2b(EUCOMM)Wtsi 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 5.08×10-05
Ppp2r2b
Ppp2r2btm1b(KOMP)Wtsi 		HOM   Early adult decreased heart rate variability HRV
Electrocardiogram (ECG)		 TCP
IMPC		 5.19×10-05
Dnajc21
Dnajc21tm1.1(NCOM)Mfgc 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 TCP
IMPC		 5.45×10-05
Orai1
Orai1tm1b(EUCOMM)Hmgu 		HET   Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 BCM
IMPC		 6.00×10-05
Pigo
Pigotm1b(EUCOMM)Wtsi 		HET   Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 6.22×10-05
Gbp2
Gbp2tm1b(KOMP)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 HMGU
IMPC		 6.79×10-05
4931406C07Rik
4931406C07Riktm1b(EUCOMM)Wtsi 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 7.03×10-05
Pcyox1l
Pcyox1lem1(IMPC)J 		HOM Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 JAX
IMPC		 7.52×10-05
Tmtc3
Tmtc3tm1b(EUCOMM)Wtsi 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 BCM
IMPC		 7.83×10-05
Cog7
Cog7tm1b(EUCOMM)Hmgu 		HET Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 8.14×10-05
Slc8b1
Slc8b1em1(IMPC)J 		HOM Early adult abnormal sinus arrhythmia rMSSD
Electrocardiogram (ECG)		 JAX
IMPC		 8.16×10-05
Syn3
Syn3tm1.1(KOMP)Vlcg 		HOM   Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 JAX
IMPC		 8.73×10-05
Bicdl1
Bicdl1tm2b(EUCOMM)Wtsi 		HET Early adult increased heart rate variability HRV
Electrocardiogram (ECG)		 BCM
IMPC		 9.31×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

2.10% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal sinus arrhythmia (54/2576)

1.26% females (32/2539) 0.59% males (15/2535)

Select a parameter    



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