Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,
abnormal LV,
abnormal left ventricle morphology
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with abnormal heart left ventricle morphology
Total number of significant genotype-phenotype associations: 96
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Alpk3 Alpk3tm1b(EUCOMM)Hmgu |
HOM | Early adult | dilated heart left ventricle | End-Diastolic Diameter Echo |
MRC Harwell IMPC |
0.00 | |
| Zfp280d Zfp280dem1(IMPC)Hmgu |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
HMGU IMPC |
7.25×10-21 | |
| Eftud2 Eftud2tm1b(KOMP)Wtsi |
HET | Early adult | increased heart left ventricle size | LVAWd Echo |
ICS IMPC |
1.47×10-11 | |
| Prdm4 Prdm4tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
MRC Harwell IMPC |
1.07×10-10 | |
| Erg Ergem1(IMPC)Bay |
HET | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
5.77×10-10 | |
| Nudt5 Nudt5tm1b(EUCOMM)Hmgu |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
1.50×10-09 | |
| Ints6l Ints6lem1(IMPC)Marc |
HEM | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
7.56×10-09 | |
| Gngt2 Gngt2em1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
7.74×10-09 | |
| Ints6l Ints6lem1(IMPC)Marc |
HEM | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
4.42×10-08 | |
| Alpk3 Alpk3tm1b(EUCOMM)Hmgu |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
MRC Harwell IMPC |
4.96×10-08 | |
| Slc10a2 Slc10a2tm1b(KOMP)Mbp |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
6.87×10-08 | |
| Col1a2 Col1a2tm1b(EUCOMM)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDd Echo |
BCM IMPC |
1.00×10-07 | |
| Zdhhc2 Zdhhc2tm1b(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDd Echo |
MARC IMPC |
1.64×10-07 | |
| Atad5 Atad5em1(IMPC)Bay |
HET | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
1.89×10-07 | |
| Nek1 Nek1em1(IMPC)Bay |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
BCM IMPC |
1.99×10-07 | |
| Pex1 Pex1tm1e.1(EUCOMM)Hmgu |
HET | Early adult | dilated heart left ventricle | LVIDs Echo |
HMGU IMPC |
2.20×10-07 | |
| Slc2a12 Slc2a12em2(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.52×10-07 | |
| Aars2 Aars2tm1(KOMP)Wtsi |
HET | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
MARC IMPC |
3.79×10-07 | |
| Bsdc1 Bsdc1em1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
3.83×10-07 | |
| Aldob Aldobtm2b(EUCOMM)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
BCM IMPC |
4.24×10-07 | |
| Hells Hellstm1b(EUCOMM)Wtsi |
HET | Early adult | dilated heart left ventricle | LVIDd Echo |
HMGU IMPC |
8.78×10-07 | |
| Mir350 Mir350tm1(mirKO)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
MARC IMPC |
8.79×10-07 | |
| Grem2 Grem2em1(IMPC)Bay |
HET | Early adult | dilated heart left ventricle | LVIDd Echo |
BCM IMPC |
9.75×10-07 | |
| Ascc2 Ascc2tm1b(EUCOMM)Wtsi |
HET | Early adult | decreased heart left ventricle size | LVAWd Echo |
BCM IMPC |
1.05×10-06 | |
| Arhgap24 Arhgap24tm1b(KOMP)Wtsi |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
ICS IMPC |
1.49×10-06 | |
| Skil Skiltm1b(EUCOMM)Hmgu |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.23×10-06 | |
| Leprotl1 Leprotl1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
MRC Harwell IMPC |
2.28×10-06 | |
| Fzd8 Fzd8em1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.47×10-06 | |
| Dsg2 Dsg2tm1b(EUCOMM)Wtsi |
HOM | Early adult | dilated heart left ventricle | End-Systolic Diameter Echo |
BCM IMPC |
3.08×10-06 | |
| Fbxo36 Fbxo36tm1b(KOMP)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
MARC IMPC |
3.19×10-06 | |
| Apol10b Apol10btm1b(KOMP)Wtsi |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
3.53×10-06 | |
| Dnd1 Dnd1em1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
4.39×10-06 | |
| Calb1 Calb1em1(IMPC)Ccpcz |
HOM | Early adult | abnormal heart left ventricle morphology | End-Systolic Diameter Echo |
CCP-IMG IMPC |
4.61×10-06 | |
| Prdm8 Prdm8em1(IMPC)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | End-Diastolic Diameter Echo |
CCP-IMG IMPC |
4.63×10-06 | |
| Eftud2 Eftud2tm1b(KOMP)Wtsi |
HET | Late adult | decreased heart left ventricle size | LVAWd Echo |
ICS IMPC |
4.82×10-06 | |
| Abhd3 Abhd3em1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
4.90×10-06 | |
| Fam126a Fam126aem1(IMPC)Ccpcz |
HOM | Early adult | dilated heart left ventricle | LVIDd Echo |
CCP-IMG IMPC |
5.76×10-06 | |
| Ints6l Ints6lem1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
8.58×10-06 | |
| Gsdmd Gsdmdem1(IMPC)Marc |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
9.90×10-06 | |
| Gsdmd Gsdmdem1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
9.94×10-06 | |
| Sirt1 Sirt1tm1b(EUCOMM)Wtsi |
HET | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
MRC Harwell IMPC |
1.39×10-05 | |
| Aoc1 Aoc1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
HMGU IMPC |
1.44×10-05 | |
| Ppp1r14d Ppp1r14dtm1b(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
1.47×10-05 | |
| Atg4d Atg4dem1(IMPC)Marc |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
1.51×10-05 | |
| Map3k12 Map3k12tm1b(EUCOMM)Hmgu |
HET | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
1.54×10-05 | |
| Cdc123 Cdc123tm1b(KOMP)Wtsi |
HET | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
HMGU IMPC |
1.62×10-05 | |
| Eftud2 Eftud2tm1b(KOMP)Wtsi |
HET | Late adult | abnormal heart left ventricle morphology | LVIDs Echo |
ICS IMPC |
1.73×10-05 | |
| Kdm2b Kdm2bem1(IMPC)Marc |
HET | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
1.93×10-05 | |
| Dusp7 Dusp7tm1(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDd Echo |
MARC IMPC |
1.95×10-05 | |
| Trim37 Trim37em1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
1.96×10-05 | |
| Dnase1l2 Dnase1l2tm1.1(KOMP)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
BCM IMPC |
1.97×10-05 | |
| Snx25 Snx25tm1b(KOMP)Wtsi |
HET | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
2.01×10-05 | |
| Rxfp3 Rxfp3em1(IMPC)Bay |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
BCM IMPC |
2.03×10-05 | |
| Ube2z Ube2zem1(IMPC)Marc |
HET | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
2.18×10-05 | |
| Fam131a Fam131aem1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.21×10-05 | |
| Rxfp3 Rxfp3em1(IMPC)Bay |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.23×10-05 | |
| Prmt6 Prmt6em1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
2.33×10-05 | |
| Wars Warstm1b(EUCOMM)Hmgu |
HET | Early adult | dilated heart left ventricle | LVIDs Echo |
HMGU IMPC |
2.39×10-05 | |
| Ufm1 Ufm1em1(IMPC)Marc |
HET | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
2.56×10-05 | |
| Mthfd2 Mthfd2tm1b(EUCOMM)Wtsi |
HET | Early adult | increased heart left ventricle size | LVAWd Echo |
BCM IMPC |
2.97×10-05 | |
| Vav2 Vav2em1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
3.07×10-05 | |
| Phf21b Phf21bem1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
3.09×10-05 | |
| Btbd3 Btbd3tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | End-Diastolic Diameter Echo |
CCP-IMG IMPC |
3.25×10-05 | |
| Aak1 Aak1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
ICS IMPC |
3.41×10-05 | |
| Abcg8 Abcg8tm1b(KOMP)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | End-Systolic Diameter Echo |
CCP-IMG IMPC |
3.55×10-05 | |
| Mapkap1 Mapkap1tm1b(EUCOMM)Wtsi |
HET | Early adult | dilated heart left ventricle | LVIDd Echo |
BCM IMPC |
4.16×10-05 | |
| Phf8 Phf8tm1dIcs |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
ICS IMPC |
4.65×10-05 | |
| Thra Thratm1b(EUCOMM)Wtsi |
HET | Late adult | abnormal heart left ventricle morphology | LVIDs Echo |
ICS IMPC |
4.76×10-05 | |
| Hilpda Hilpdaem1(IMPC)Mhzh |
HOM | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
5.46×10-05 | |
| Adipor1 Adipor1tm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | End-Systolic Diameter Echo |
MRC Harwell IMPC |
5.81×10-05 | |
| Ccdc83 Ccdc83em1(IMPC)Marc |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
5.91×10-05 | |
| Il17rd Il17rdtm1b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDd Echo |
MRC Harwell IMPC |
6.11×10-05 | |
| Eddm3b Eddm3btm1b(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDd Echo |
MARC IMPC |
6.15×10-05 | |
| Abhd3 Abhd3em1(IMPC)Marc |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
MARC IMPC |
6.18×10-05 | |
| Pcdhgc3 Pcdhgc3em1(IMPC)Hmgu |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
HMGU IMPC |
6.43×10-05 | |
| Arhgap40 Arhgap40tm1b(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | End-Diastolic Diameter Echo |
BCM IMPC |
7.15×10-05 | |
| Btbd8 Btbd8em1(IMPC)Ccpcz |
HOM | Early adult | increased heart left ventricle size | LVAWd Echo |
CCP-IMG IMPC |
7.61×10-05 | |
| Ap1ar Ap1artm2b(EUCOMM)Hmgu |
HOM | Early adult | dilated heart left ventricle | End-Diastolic Diameter Echo |
BCM IMPC |
7.78×10-05 | |
| Mpo Mpotm1b(KOMP)Wtsi |
HET | Early adult | dilated heart left ventricle | LVIDd Echo |
MRC Harwell IMPC |
8.11×10-05 | |
| Fbxo22 Fbxo22tm1b(EUCOMM)Wtsi |
HET | Early adult | decreased heart left ventricle size | LVAWd Echo |
MARC IMPC |
8.13×10-05 | |
| Ptch2 Ptch2tm3b(EUCOMM)Hmgu |
HOM | Early adult | abnormal heart left ventricle morphology | End-Systolic Diameter Echo |
MRC Harwell IMPC |
8.19×10-05 | |
| Emc4 Emc4tm1(KOMP)Wtsi |
HET | Early adult | decreased heart left ventricle size | LVPWs Echo |
MARC IMPC |
8.24×10-05 | |
| Nr1d1 Nr1d1tm1(KOMP)Vlcg |
HOM | Early adult | decreased heart left ventricle size | LVAWd Echo |
BCM IMPC |
8.25×10-05 | |
| Ncam2 Ncam2tm1b(EUCOMM)Hmgu |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
ICS IMPC |
8.28×10-05 | |
| Efcab14 Efcab14tm1b(KOMP)Wtsi |
HOM | Early adult | dilated heart left ventricle | LVIDs Echo |
BCM IMPC |
8.73×10-05 | |
| Hmcn2 Hmcn2tm1b(EUCOMM)Wtsi |
HOM | Early adult | abnormal heart left ventricle morphology | LVIDs Echo |
BCM IMPC |
9.44×10-05 | |
| Kansl1 Kansl1tm1b(EUCOMM)Hmgu |
HET | Early adult | dilated heart left ventricle | LVIDs Echo |
ICS IMPC |
9.56×10-05 |