MP:0003921 (abnormal heart left ventricle morphology) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

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Phenotype: abnormal heart left ventricle morphology

Definition

any structural anomaly of the left lower chamber of the heart

Synonyms

LV abnormality, abnormal LV, abnormal left ventricle morphology

Significant gene associations The way we measure Phenotype stats

of tested genes

significant genes

tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 95

Gene / Allele	Zygosity	Life Stage	Phenotype	Procedure \| Parameter	Phenotyping Center \| Source	P Value
Alpk3 Alpk3^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MRC Harwell \| IMPC	0.00
Shox2 Shox2^em1(IMPC)Bay	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	1.40×10^-11
Ints6l Ints6l^{em1(IMPC)Marc}	HEM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	7.82×10^-10
Apol10b Apol10b^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	6.78×10^-09
Alpk3 Alpk3^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	MRC Harwell \| IMPC	1.61×10^-08
Cav1 Cav1^em2(IMPC)Ics	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	ICS \| IMPC	2.17×10^-08
Ints6l Ints6l^{em1(IMPC)Marc}	HEM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	MARC \| IMPC	6.36×10^-08
Slc10a2 Slc10a2^{tm1b(KOMP)Mbp}	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	8.51×10^-08
Prdm4 Prdm4^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	MRC Harwell \| IMPC	1.26×10^-07
Gngt2 Gngt2^em1(IMPC)Bay	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	1.70×10^-07
Adtrp Adtrp^em1(IMPC)Bay	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	BCM \| IMPC	2.57×10^-07
Nek1 Nek1^em1(IMPC)Bay	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	BCM \| IMPC	2.58×10^-07
Mapkap1 Mapkap1^{tm1b(EUCOMM)Wtsi}	HET	Early adult	dilated heart left ventricle	Echo \| LVIDd	BCM \| IMPC	3.29×10^-07
Bbs5 Bbs5^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| End-Diastolic Diameter	MRC Harwell \| IMPC	3.74×10^-07
Dsg2 Dsg2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	BCM \| IMPC	4.40×10^-07
Ints6l Ints6l^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	4.93×10^-07
Golt1b Golt1b^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	HMGU \| IMPC	5.87×10^-07
Klhl29 Klhl29^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	ICS \| IMPC	8.02×10^-07
Col1a2 Col1a2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDd	BCM \| IMPC	1.02×10^-06
Ascc2 Ascc2^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	1.05×10^-06
Yae1d1 Yae1d1^{tm1b(EUCOMM)Hmgu}	HET	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	HMGU \| IMPC	1.48×10^-06
Suv39h2 Suv39h2^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	1.57×10^-06
Skil Skil^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	1.90×10^-06
Fzd8 Fzd8^em1(IMPC)Bay	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	2.18×10^-06
Nr1d1 Nr1d1^{tm1.1(KOMP)Vlcg}	HET	Early adult	decreased heart left ventricle size	Echo \| LVPWs	BCM \| IMPC	2.22×10^-06
Arhgap40 Arhgap40^{tm1b(KOMP)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| End-Diastolic Diameter	BCM \| IMPC	2.22×10^-06
Eftud2 Eftud2^{tm1b(KOMP)Wtsi}	HET	Late adult	decreased heart left ventricle size	Echo \| LVAWd	ICS \| IMPC	3.38×10^-06
Gsdmd Gsdmd^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	MARC \| IMPC	4.14×10^-06
Grem2 Grem2^em1(IMPC)Bay	HET	Early adult	dilated heart left ventricle	Echo \| End-Diastolic Diameter	BCM \| IMPC	4.45×10^-06
Slc2a12 Slc2a12^em2(IMPC)Bay	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	4.67×10^-06
Erg Erg^em1(IMPC)Bay	HET	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	6.45×10^-06
Ube2z Ube2z^{em1(IMPC)Marc}	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	7.22×10^-06
Prmt6 Prmt6^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	7.52×10^-06
Ap1ar Ap1ar^{tm2b(EUCOMM)Hmgu}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDd	BCM \| IMPC	7.73×10^-06
Mthfd2 Mthfd2^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	8.07×10^-06
Tmem169 Tmem169^{em1(IMPC)Mhzh}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	8.63×10^-06
Gsdmd Gsdmd^{em1(IMPC)Marc}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	9.95×10^-06
Arhgap24 Arhgap24^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	ICS \| IMPC	1.00×10^-05
Vav2 Vav2^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	1.06×10^-05
Hmcn2 Hmcn2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	BCM \| IMPC	1.07×10^-05
Fam126a Fam126a^{em1(IMPC)Ccpcz}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDd	CCP-IMG \| IMPC	1.14×10^-05
Lmo1 Lmo1^{tm1b(KOMP)Mbp}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	HMGU \| IMPC	1.34×10^-05
Prkab1 Prkab1^{tm1b(KOMP)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	CCP-IMG \| IMPC	1.35×10^-05
Kdm2b Kdm2b^{em1(IMPC)Marc}	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	1.39×10^-05
Sirt1 Sirt1^{tm1b(EUCOMM)Wtsi}	HET	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	MRC Harwell \| IMPC	1.61×10^-05
Taok2 Taok2^{tm1b(EUCOMM)Hmgu}	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	ICS \| IMPC	1.67×10^-05
Map3k12 Map3k12^{tm1b(EUCOMM)Hmgu}	HET	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	1.68×10^-05
Siva1 Siva1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	HMGU \| IMPC	1.79×10^-05
Snx25 Snx25^{tm1b(KOMP)Wtsi}	HET	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	1.98×10^-05
Phf21b Phf21b^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	2.02×10^-05
Atad5 Atad5^em1(IMPC)Bay	HET	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	2.05×10^-05
Aoc1 Aoc1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	HMGU \| IMPC	2.05×10^-05
Ccdc83 Ccdc83^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	2.08×10^-05
Rnf10 Rnf10^em1(IMPC)Bay	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	2.10×10^-05
Rxfp3 Rxfp3^em1(IMPC)Bay	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	BCM \| IMPC	2.12×10^-05
Zfp488 Zfp488^em1(IMPC)Bay	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	2.19×10^-05
Abhd3 Abhd3^{em1(IMPC)Marc}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	2.27×10^-05
Scarb1 Scarb1^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| End-Systolic Diameter	BCM \| IMPC	2.60×10^-05
Usp31 Usp31^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	2.80×10^-05
Fbxo22 Fbxo22^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	2.92×10^-05
Rasgrp3 Rasgrp3^{em1(IMPC)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| End-Diastolic Diameter	CCP-IMG \| IMPC	3.15×10^-05
Thra Thra^{tm1b(EUCOMM)Wtsi}	HET	Late adult	abnormal heart left ventricle morphology	Echo \| LVIDd	ICS \| IMPC	3.19×10^-05
Ap4e1 Ap4e1^{tm1b(KOMP)Wtsi}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	HMGU \| IMPC	3.22×10^-05
Esr2 Esr2^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	3.26×10^-05
Fbxo10 Fbxo10^{tm1b(KOMP)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDs	MARC \| IMPC	3.35×10^-05
Churc1 Churc1^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	dilated heart left ventricle	Echo \| End-Systolic Diameter	CCP-IMG \| IMPC	3.42×10^-05
Wsb2 Wsb2^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	dilated heart left ventricle	Echo \| LVIDd	HMGU \| IMPC	3.77×10^-05
Itm2c Itm2c^{tm1b(EUCOMM)Wtsi}	HET	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	HMGU \| IMPC	3.80×10^-05
Trim37 Trim37^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	MARC \| IMPC	3.95×10^-05
Aak1 Aak1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	ICS \| IMPC	4.02×10^-05
Pex1 Pex1^{tm1e.1(EUCOMM)Hmgu}	HET	Early adult	dilated heart left ventricle	Echo \| LVIDs	HMGU \| IMPC	4.18×10^-05
Fam83h Fam83h^{em1(IMPC)Ccpcz}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	CCP-IMG \| IMPC	4.40×10^-05
Leprotl1 Leprotl1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| End-Systolic Diameter	MRC Harwell \| IMPC	4.57×10^-05
Phf8 Phf8^tm1dIcs	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	ICS \| IMPC	4.71×10^-05
Cenpv Cenpv^{em1(IMPC)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	HMGU \| IMPC	5.34×10^-05
Asb7 Asb7^{em1(IMPC)Ccpcz}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDs	CCP-IMG \| IMPC	5.35×10^-05
Eftud2 Eftud2^{tm1b(KOMP)Wtsi}	HET	Late adult	abnormal heart left ventricle morphology	Echo \| LVIDd	ICS \| IMPC	5.66×10^-05
Rnf19b Rnf19b^{em1(IMPC)Ccpcz}	HET	Early adult	increased heart left ventricle size	Echo \| LVAWd	CCP-IMG \| IMPC	5.86×10^-05
Khdrbs3 Khdrbs3^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	HMGU \| IMPC	6.46×10^-05
Arhgap40 Arhgap40^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	6.65×10^-05
Gm17359 Gm17359^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVPWs	BCM \| IMPC	7.53×10^-05
Bcl7a Bcl7a^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased heart left ventricle size	Echo \| LVPWs	BCM \| IMPC	7.57×10^-05
Fmc1 Fmc1^{tm1b(EUCOMM)Wtsi}	HET	Early adult	dilated heart left ventricle	Echo \| End-Systolic Diameter	BCM \| IMPC	8.04×10^-05
Il17rd Il17rd^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	abnormal heart left ventricle morphology	Echo \| LVIDd	MRC Harwell \| IMPC	8.23×10^-05
Scn2b Scn2b^em1(IMPC)Bay	HOM	Early adult	increased heart left ventricle size	Echo \| LVAWd	BCM \| IMPC	8.60×10^-05
Tent5a Tent5a^{em1(IMPC)Ccpcz}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	CCP-IMG \| IMPC	9.50×10^-05
Abhd3 Abhd3^{em1(IMPC)Marc}	HOM	Early adult	decreased heart left ventricle size	Echo \| LVAWd	MARC \| IMPC	9.77×10^-05

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The way we measure

Procedure
Echo

Phenotype associations stats

4.66% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (80/1716)

1.24% females (21/1695) 1.41% males (20/1423)

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Phenotype: abnormal heart left ventricle morphology

IMPC Gene variants with abnormal heart left ventricle morphology

The way we measure

Phenotype associations stats

The IMPC Newsletter

Access Data Release 14.0 Data