Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal LV,  abnormal left ventricle morphology
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 96

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
MRC Harwell
IMPC
0.00
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
7.25×10-21
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.47×10-11
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology LVIDs
Echo
MRC Harwell
IMPC
1.07×10-10
Erg
Ergem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.77×10-10
Nudt5
Nudt5tm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.50×10-09
Ints6l
Ints6lem1(IMPC)Marc
HEM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
7.56×10-09
Gngt2
Gngt2em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
7.74×10-09
Ints6l
Ints6lem1(IMPC)Marc
HEM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
4.42×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart left ventricle size LVAWd
Echo
MRC Harwell
IMPC
4.96×10-08
Slc10a2
Slc10a2tm1b(KOMP)Mbp
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
6.87×10-08
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
1.00×10-07
Zdhhc2
Zdhhc2tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
1.64×10-07
Atad5
Atad5em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.89×10-07
Nek1
Nek1em1(IMPC)Bay
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
1.99×10-07
Pex1
Pex1tm1e.1(EUCOMM)Hmgu
HET Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
2.20×10-07
Slc2a12
Slc2a12em2(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.52×10-07
Aars2
Aars2tm1(KOMP)Wtsi
HET Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
3.79×10-07
Bsdc1
Bsdc1em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
3.83×10-07
Aldob
Aldobtm2b(EUCOMM)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
4.24×10-07
Hells
Hellstm1b(EUCOMM)Wtsi
HET Early adult dilated heart left ventricle LVIDd
Echo
HMGU
IMPC
8.78×10-07
Mir350
Mir350tm1(mirKO)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
8.79×10-07
Grem2
Grem2em1(IMPC)Bay
HET   Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
9.75×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi
HET Early adult decreased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.05×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.49×10-06
Skil
Skiltm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.23×10-06
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
MRC Harwell
IMPC
2.28×10-06
Fzd8
Fzd8em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.47×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM   Early adult dilated heart left ventricle End-Systolic Diameter
Echo
BCM
IMPC
3.08×10-06
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
3.19×10-06
Apol10b
Apol10btm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
3.53×10-06
Dnd1
Dnd1em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
4.39×10-06
Calb1
Calb1em1(IMPC)Ccpcz
HOM   Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
CCP-IMG
IMPC
4.61×10-06
Prdm8
Prdm8em1(IMPC)Wtsi
HOM   Early adult abnormal heart left ventricle morphology End-Diastolic Diameter
Echo
CCP-IMG
IMPC
4.63×10-06
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Late adult decreased heart left ventricle size LVAWd
Echo
ICS
IMPC
4.82×10-06
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
4.90×10-06
Fam126a
Fam126aem1(IMPC)Ccpcz
HOM   Early adult dilated heart left ventricle LVIDd
Echo
CCP-IMG
IMPC
5.76×10-06
Ints6l
Ints6lem1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
8.58×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
9.90×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
9.94×10-06
Sirt1
Sirt1tm1b(EUCOMM)Wtsi
HET   Early adult abnormal heart left ventricle morphology LVIDd
Echo
MRC Harwell
IMPC
1.39×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
HMGU
IMPC
1.44×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
1.47×10-05
Atg4d
Atg4dem1(IMPC)Marc
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
1.51×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.54×10-05
Cdc123
Cdc123tm1b(KOMP)Wtsi
HET   Early adult abnormal heart left ventricle morphology LVIDs
Echo
HMGU
IMPC
1.62×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET   Late adult abnormal heart left ventricle morphology LVIDs
Echo
ICS
IMPC
1.73×10-05
Kdm2b
Kdm2bem1(IMPC)Marc
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
1.93×10-05
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
1.95×10-05
Trim37
Trim37em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
1.96×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
1.97×10-05
Snx25
Snx25tm1b(KOMP)Wtsi
HET Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
2.01×10-05
Rxfp3
Rxfp3em1(IMPC)Bay
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
BCM
IMPC
2.03×10-05
Ube2z
Ube2zem1(IMPC)Marc
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
2.18×10-05
Fam131a
Fam131aem1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.21×10-05
Rxfp3
Rxfp3em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.23×10-05
Prmt6
Prmt6em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
2.33×10-05
Wars
Warstm1b(EUCOMM)Hmgu
HET   Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
2.39×10-05
Ufm1
Ufm1em1(IMPC)Marc
HET Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
2.56×10-05
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.97×10-05
Vav2
Vav2em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
3.07×10-05
Phf21b
Phf21bem1(IMPC)Marc
HOM Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
3.09×10-05
Btbd3
Btbd3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology End-Diastolic Diameter
Echo
CCP-IMG
IMPC
3.25×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
ICS
IMPC
3.41×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi
HOM   Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
CCP-IMG
IMPC
3.55×10-05
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi
HET Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
4.16×10-05
Phf8
Phf8tm1dIcs
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
ICS
IMPC
4.65×10-05
Thra
Thratm1b(EUCOMM)Wtsi
HET   Late adult abnormal heart left ventricle morphology LVIDs
Echo
ICS
IMPC
4.76×10-05
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
5.46×10-05
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
MRC Harwell
IMPC
5.81×10-05
Ccdc83
Ccdc83em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
5.91×10-05
Il17rd
Il17rdtm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
MRC Harwell
IMPC
6.11×10-05
Eddm3b
Eddm3btm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
6.15×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
6.18×10-05
Pcdhgc3
Pcdhgc3em1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
6.43×10-05
Arhgap40
Arhgap40tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
7.15×10-05
Btbd8
Btbd8em1(IMPC)Ccpcz
HOM Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
7.61×10-05
Ap1ar
Ap1artm2b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
7.78×10-05
Mpo
Mpotm1b(KOMP)Wtsi
HET   Early adult dilated heart left ventricle LVIDd
Echo
MRC Harwell
IMPC
8.11×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
8.13×10-05
Ptch2
Ptch2tm3b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
MRC Harwell
IMPC
8.19×10-05
Emc4
Emc4tm1(KOMP)Wtsi
HET Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
8.24×10-05
Nr1d1
Nr1d1tm1(KOMP)Vlcg
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
BCM
IMPC
8.25×10-05
Ncam2
Ncam2tm1b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
ICS
IMPC
8.28×10-05
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDs
Echo
BCM
IMPC
8.73×10-05
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
BCM
IMPC
9.44×10-05
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET Early adult dilated heart left ventricle LVIDs
Echo
ICS
IMPC
9.56×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

4.24% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (79/1862)

1.52% females (28/1839) 1.41% males (22/1557)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter