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Genes Phenotypes

Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal LV,  abnormal left ventricle morphology
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 99

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM   Early adult dilated heart left ventricle Echo | End-Systolic Diameter MRC Harwell | IMPC 0.00
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter CCP-IMG | IMPC 0.00
Shox2
Shox2em1(IMPC)Bay 		HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.51×10-11
Ints6l
Ints6lem1(IMPC)Marc 		HEM   Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 3.09×10-09
Apol10b
Apol10btm1b(KOMP)Wtsi 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 7.34×10-09
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM   Early adult increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 1.55×10-08
Asb7
Asb7em1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs CCP-IMG | IMPC 2.69×10-08
Ints6l
Ints6lem1(IMPC)Marc 		HEM   Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 6.36×10-08
Cnpy2
Cnpy2em1(IMPC)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 7.44×10-08
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 7.56×10-08
Slc10a2
Slc10a2tm1b(KOMP)Mbp 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 8.48×10-08
Gngt2
Gngt2em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.64×10-07
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 1.69×10-07
Adtrp
Adtrpem1(IMPC)Bay 		HOM Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 2.14×10-07
Nek1
Nek1em1(IMPC)Bay 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 2.70×10-07
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi 		HET Early adult dilated heart left ventricle Echo | LVIDd BCM | IMPC 3.43×10-07
Dsg2
Dsg2tm1b(EUCOMM)Wtsi 		HOM   Early adult dilated heart left ventricle Echo | LVIDs BCM | IMPC 4.22×10-07
Ints6l
Ints6lem1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 4.93×10-07
Suv39h2
Suv39h2em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 5.64×10-07
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET   Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 5.94×10-07
Rasgrp3
Rasgrp3em1(IMPC)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 6.54×10-07
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 8.02×10-07
Nwd2
Nwd2em1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter CCP-IMG | IMPC 8.95×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.05×10-06
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDd BCM | IMPC 1.05×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 1.12×10-06
Adipor1
Adipor1tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.20×10-06
Retreg3
Retreg3tm2b(EUCOMM)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 1.48×10-06
Hectd3
Hectd3tm1(NCOM)Cmhd 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 1.73×10-06
Skil
Skiltm1b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.03×10-06
Nr1d1
Nr1d1tm1.1(KOMP)Vlcg 		HET   Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 2.07×10-06
Arhgap40
Arhgap40tm1b(KOMP)Wtsi 		HOM Early adult dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 2.33×10-06
Fzd8
Fzd8em1(IMPC)Bay 		HOM   Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.35×10-06
Lmo1
Lmo1tm1b(KOMP)Mbp 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.74×10-06
Btbd3
Btbd3tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter CCP-IMG | IMPC 3.34×10-06
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.14×10-06
Atp5md
Atp5mdtm1b(EUCOMM)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 4.38×10-06
Grem2
Grem2em1(IMPC)Bay 		HET   Early adult dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 4.45×10-06
Slc2a12
Slc2a12em2(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.70×10-06
Marchf6
Marchf6tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 4.95×10-06
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM   Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 5.32×10-06
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs MRC Harwell | IMPC 5.89×10-06
Erg
Ergem1(IMPC)Bay 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 6.57×10-06
Ube2z
Ube2zem1(IMPC)Marc 		HET   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.22×10-06
Prmt6
Prmt6em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.52×10-06
Ap1ar
Ap1artm2b(EUCOMM)Hmgu 		HOM Early adult dilated heart left ventricle Echo | LVIDd BCM | IMPC 7.83×10-06
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 8.18×10-06
Fam83h
Fam83hem1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd CCP-IMG | IMPC 8.26×10-06
Tmem169
Tmem169em1(IMPC)Mhzh 		HOM   Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 8.63×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi 		HOM   Early adult increased heart left ventricle size Echo | LVAWd ICS | IMPC 1.00×10-05
Vav2
Vav2em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.06×10-05
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 1.11×10-05
Adprm
Adprmtm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.27×10-05
Kdm2b
Kdm2bem1(IMPC)Marc 		HET   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.39×10-05
Taok2
Taok2tm1b(EUCOMM)Hmgu 		HET   Early adult decreased heart left ventricle size Echo | LVAWd ICS | IMPC 1.67×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.69×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.70×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.81×10-05
Snx25
Snx25tm1b(KOMP)Wtsi 		HET Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 1.98×10-05
Phf21b
Phf21bem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.02×10-05
Ccdc83
Ccdc83em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.08×10-05
Atad5
Atad5em1(IMPC)Bay 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.14×10-05
Rxfp3
Rxfp3em1(IMPC)Bay 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 2.16×10-05
Insig1
Insig1em1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter CCP-IMG | IMPC 2.26×10-05
Zfp488
Zfp488em1(IMPC)Bay 		HOM Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 2.31×10-05
Rnf10
Rnf10em1(IMPC)Bay 		HOM   Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.45×10-05
Mir350
Mir350tm1(mirKO)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 2.55×10-05
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HOM   Early adult dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 2.60×10-05
Usp31
Usp31em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.80×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi 		HET   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.92×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM   Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.93×10-05
Hace1
Hace1tm1b(KOMP)Wtsi 		HET   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 3.02×10-05
Esr2
Esr2em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.26×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 3.58×10-05
Golt1b
Golt1btm1b(EUCOMM)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 3.63×10-05
Trim37
Trim37em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 3.95×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 4.02×10-05
Phf8
Phf8tm1dIcs 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 4.71×10-05
Nrxn1
Nrxn1tm1b(KOMP)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.92×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 5.42×10-05
Epc2
Epc2tm1b(EUCOMM)Wtsi 		HET   Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 5.72×10-05
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 5.93×10-05
Zfp644
Zfp644em1(IMPC)Ccpcz 		HOM   Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter CCP-IMG | IMPC 6.16×10-05
Arhgap40
Arhgap40tm1b(KOMP)Wtsi 		HOM Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 6.32×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM   Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 6.98×10-05
Khdrbs3
Khdrbs3tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 7.05×10-05
Fmc1
Fmc1tm1b(EUCOMM)Wtsi 		HET   Early adult dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 7.90×10-05
Rnf19b
Rnf19bem1(IMPC)Ccpcz 		HET   Early adult increased heart left ventricle size Echo | LVAWd CCP-IMG | IMPC 7.99×10-05
Gm17359
Gm17359tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 8.02×10-05
Bcl7a
Bcl7atm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 8.32×10-05
Scn2b
Scn2bem1(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 8.61×10-05
Fdx1
Fdx1tm1b(EUCOMM)Wtsi 		HET   Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 9.39×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 9.77×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

5.26% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (87/1653)

1.16% females (19/1632) 1.25% males (17/1360)

Select a parameter    



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