Genes Phenotypes

Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 142

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 0.00
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MRC Harwell | IMPC 2.78×10-15
Shox2
Shox2em1(IMPC)Bay 		HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.51×10-11
Usp26
Usp26em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 3.50×10-11
Nr1d1
Nr1d1tm1(KOMP)Vlcg 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 5.57×10-11
Ints6l
Ints6lem1(IMPC)Marc 		HEM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.82×10-10
Slc10a2
Slc10a2tm1b(KOMP)Mbp 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 8.11×10-10
Gngt2
Gngt2em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 1.34×10-09
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 3.05×10-09
Adtrp
Adtrpem1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 3.88×10-09
Apol10b
Apol10btm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 7.34×10-09
Grem2
Grem2em1(IMPC)Bay 		HET Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 9.64×10-09
Bbs5
Bbs5tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 1.93×10-08
Ints6l
Ints6lem1(IMPC)Marc 		HEM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.36×10-08
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 7.05×10-08
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.26×10-07
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 1.28×10-07
Adtrp
Adtrpem1(IMPC)Bay 		HOM Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 2.14×10-07
Nudt5
Nudt5tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 2.41×10-07
Nek1
Nek1em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 2.70×10-07
Dsg2
Dsg2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 4.22×10-07
Ints6l
Ints6lem1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 4.93×10-07
Phf21b
Phf21bem1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 5.49×10-07
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 8.02×10-07
Efcab14
Efcab14tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 8.64×10-07
Phf8
Phf8em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 8.91×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.05×10-06
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDd BCM | IMPC 1.05×10-06
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi 		HET Early adult dilated heart left ventricle Echo | LVIDs BCM | IMPC 1.09×10-06
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.42×10-06
Suv39h2
Suv39h2em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.57×10-06
Skil
Skiltm1b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.03×10-06
Nr1d1
Nr1d1tm1.1(KOMP)Vlcg 		HET Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 2.07×10-06
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle size Echo | LVPWd HMGU | IMPC 2.16×10-06
Vav2
Vav2em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.21×10-06
Esr2
Esr2em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.23×10-06
Arhgap40
Arhgap40tm1b(KOMP)Wtsi 		HOM Early adult dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 2.33×10-06
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 2.48×10-06
Slc2a12
Slc2a12em2(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.55×10-06
Mybbp1a
Mybbp1atm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle size Echo | LVPWd HMGU | IMPC 2.94×10-06
Lmo1
Lmo1tm1b(KOMP)Mbp 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 3.07×10-06
Pja2
Pja2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 3.45×10-06
Bsdc1
Bsdc1em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 4.14×10-06
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs MARC | IMPC 4.14×10-06
Grem2
Grem2em1(IMPC)Bay 		HET Early adult dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 4.45×10-06
Slc2a12
Slc2a12em2(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.70×10-06
Erg
Ergem1(IMPC)Bay 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 6.57×10-06
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 6.98×10-06
Ube2z
Ube2zem1(IMPC)Marc 		HET Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 7.22×10-06
Prmt6
Prmt6em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 7.52×10-06
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.56×10-06
Chst12
Chst12em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 7.78×10-06
Ap1ar
Ap1artm2b(EUCOMM)Hmgu 		HOM Early adult dilated heart left ventricle Echo | LVIDd BCM | IMPC 7.83×10-06
Zfp235
Zfp235tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 8.33×10-06
Tmem169
Tmem169em1(IMPC)Mhzh 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 8.63×10-06
Fcrl6
Fcrl6tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MRC Harwell | IMPC 9.04×10-06
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 9.95×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd ICS | IMPC 1.00×10-05
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 1.11×10-05
Nos1ap
Nos1aptm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 1.13×10-05
Kdm2b
Kdm2bem1(IMPC)Marc 		HET Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 1.39×10-05
Sirt1
Sirt1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.61×10-05
Taok2
Taok2tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle size Echo | LVAWd ICS | IMPC 1.67×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.69×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 1.70×10-05
Snx25
Snx25tm1b(KOMP)Wtsi 		HET Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 1.98×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.07×10-05
Ccdc83
Ccdc83em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 2.08×10-05
Atad5
Atad5em1(IMPC)Bay 		HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.14×10-05
Rxfp3
Rxfp3em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 2.16×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.27×10-05
Zfp488
Zfp488em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.31×10-05
Rnf10
Rnf10em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.45×10-05
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter BCM | IMPC 2.60×10-05
Usp31
Usp31em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 2.80×10-05
Polr1a
Polr1atm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle size Echo | LVPWd BCM | IMPC 2.92×10-05
Trim37
Trim37em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.95×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 3.01×10-05
Emc10
Emc10tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MRC Harwell | IMPC 3.09×10-05
Hilpda
Hilpdaem1(IMPC)Mhzh 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 3.21×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 3.35×10-05
Golt1b
Golt1btm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 3.65×10-05
Itm2c
Itm2ctm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 3.92×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 4.02×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 4.08×10-05
Wsb2
Wsb2tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 4.25×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.57×10-05
Phf8
Phf8tm1dIcs 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 4.71×10-05
Gm17359
Gm17359tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 5.65×10-05
Acsm1
Acsm1em1(IMPC)Mhzh 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 5.78×10-05
Khdrbs3
Khdrbs3tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 6.01×10-05
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 6.14×10-05
Ccdc178
Ccdc178tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 6.21×10-05
Arhgap40
Arhgap40tm1b(KOMP)Wtsi 		HOM Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 6.32×10-05
Oscar
Oscartm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd BCM | IMPC 6.37×10-05
Fmc1
Fmc1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter BCM | IMPC 7.90×10-05
Khdrbs3
Khdrbs3tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVPWs HMGU | IMPC 8.02×10-05
Il17rd
Il17rdtm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 8.23×10-05
Bcl7a
Bcl7atm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 8.32×10-05
Cntn3
Cntn3em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 8.36×10-05
Snai3
Snai3tm2b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 8.58×10-05
Scn2b
Scn2bem1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 8.61×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle size Echo | LVAWs MRC Harwell | IMPC 9.27×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 9.77×10-05
Fbxo36
Fbxo36tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 9.98×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

5.57% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (89/1597)

1.68% females (26/1548) 1.24% males (16/1286)

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