Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal left ventricle morphology,  abnormal LV
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 96

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter MRC Harwell | IMPC 2.53×10-21
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs MRC Harwell | IMPC 5.63×10-11
Ints6l
Ints6lem1(IMPC)Marc
HEM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 3.47×10-09
Slc25a1
Slc25a1tm1b(EUCOMM)Wtsi
HET postnatal decreased heart left ventricle size Echo | LVAWd BCM | IMPC 6.84×10-09
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 1.01×10-08
Suv39h2
Suv39h2em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.45×10-08
Ints6l
Ints6lem1(IMPC)Marc
HEM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.08×10-08
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 4.47×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM postnatal increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 7.16×10-08
Ndufs7
Ndufs7tm1b(EUCOMM)Hmgu
HET postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 1.01×10-07
Fzd8
Fzd8em1(IMPC)Bay
HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.54×10-07
Ints6l
Ints6lem1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.83×10-07
Phf21b
Phf21bem1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 4.04×10-07
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.86×10-07
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi
HET postnatal dilated heart left ventricle Echo | LVIDs BCM | IMPC 1.84×10-06
Slc10a2
Slc10a2tm1b(KOMP)Mbp
HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.62×10-06
Ap1ar
Ap1artm2b(EUCOMM)Hmgu
HOM postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 3.39×10-06
Fzd8
Fzd8em1(IMPC)Bay
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 5.06×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 5.32×10-06
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 5.46×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 5.52×10-06
Golt1b
Golt1btm1b(EUCOMM)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 7.62×10-06
Vav2
Vav2em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.01×10-05
Kdm2b
Kdm2bem1(IMPC)Marc
HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.19×10-05
Prmt6
Prmt6em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.20×10-05
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 1.22×10-05
Apol10b
Apol10btm1b(KOMP)Wtsi
HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.22×10-05
Rnf10
Rnf10em1(IMPC)Bay
HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.23×10-05
Cdk5rap3
Cdk5rap3tm1b(EUCOMM)Hmgu
HET postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.38×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu
HET postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.40×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 1.60×10-05
Ccdc83
Ccdc83em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.74×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.01×10-05
Aars2
Aars2tm1(KOMP)Wtsi
HET postnatal abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 2.15×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.35×10-05
Ube2z
Ube2zem1(IMPC)Marc
HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.57×10-05
Rcn3
Rcn3tm1b(EUCOMM)Hmgu
HET postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 2.69×10-05
Pard3b
Pard3btm1b(EUCOMM)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.73×10-05
Esr2
Esr2em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.36×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.45×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 3.70×10-05
Scaper
Scapertm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 3.81×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM postnatal abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.11×10-05
Gsdmd
Gsdmdem1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.78×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu
HOM postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.74×10-05
Pde4dip
Pde4diptm1b(KOMP)Wtsi
HET postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 6.59×10-05
Trim37
Trim37em1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 7.21×10-05
Kcns2
Kcns2em1(IMPC)Bay
HOM postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 7.27×10-05
Ascc2
Ascc2tm1b(EUCOMM)Wtsi
HET postnatal decreased heart left ventricle size Echo | LVAWd BCM | IMPC 7.47×10-05
Itm2c
Itm2ctm1b(EUCOMM)Wtsi
HET postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.53×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.67×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc
HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.97×10-05
Ift172
Ift172tm2b(EUCOMM)Hmgu
HET postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 8.02×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 9.60×10-05
Gpr39
Gpr39em1(IMPC)Bay
HOM postnatal dilated heart left ventricle Echo | LVIDd BCM | IMPC 9.68×10-05

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 The way we measure

Procedure
Echo

 Phenotype associations stats

3.96% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (52/1313)

3.54% females (46/1299) 4.49% males (46/1024)

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