Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal LV,  abnormal left ventricle morphology
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 112

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
MRC Harwell
IMPC
0.00
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
7.65×10-21
Xrcc5
Xrcc5em1(IMPC)Ccpcz
HOM Early adult abnormal heart left ventricle morphology End-Diastolic Diameter
Echo
CCP-IMG
IMPC
6.38×10-19
Fnip1
Fnip1em1(IMPC)Ccpcz
HOM Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
4.20×10-14
Fnip1
Fnip1em1(IMPC)Ccpcz
HOM Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
CCP-IMG
IMPC
1.43×10-13
Mpp3
Mpp3tm1b(EUCOMM)Wtsi
HOM Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
MRC Harwell
IMPC
4.85×10-12
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.47×10-11
Prdm4
Prdm4tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology LVIDs
Echo
MRC Harwell
IMPC
4.92×10-10
Erg
Ergem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
4.61×10-09
Ints6l
Ints6lem1(IMPC)Marc
HEM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
7.56×10-09
Ints6l
Ints6lem1(IMPC)Marc
HEM Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
4.42×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
MRC Harwell
IMPC
4.96×10-08
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
1.07×10-07
Oxa1l
Oxa1lem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.19×10-07
Gcdh
Gcdhtm2b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.37×10-07
Rai2
Rai2em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.46×10-07
Aldob
Aldobtm2b(EUCOMM)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
1.62×10-07
Zdhhc2
Zdhhc2tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
1.64×10-07
Pex1
Pex1tm1e.1(EUCOMM)Hmgu
HET Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
2.20×10-07
Ccr2
Ccr2em1(IMPC)H
HOM Late adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
MRC Harwell
IMPC
3.20×10-07
Aars2
Aars2tm1(KOMP)Wtsi
HET Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
3.79×10-07
Slc10a2
Slc10a2tm1b(KOMP)Mbp
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
4.11×10-07
Iqcb1
Iqcb1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
6.41×10-07
Scn2b
Scn2bem1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
8.58×10-07
Hells
Hellstm1b(EUCOMM)Wtsi
HET Early adult dilated heart left ventricle LVIDd
Echo
HMGU
IMPC
8.78×10-07
Mir350
Mir350tm1Wtsi
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
8.79×10-07
Gngt2
Gngt2em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
9.11×10-07
Ube3c
Ube3ctm1b(EUCOMM)Hmgu
HOM Late adult abnormal heart left ventricle morphology LVIDs
Echo
HMGU
IMPC
9.52×10-07
Sec13
Sec13em1(IMPC)Hmgu
HET Late adult decreased heart left ventricle size LVPWs
Echo
HMGU
IMPC
9.97×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi
HET Early adult decreased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.05×10-06
Atp1a1
Atp1a1em1(IMPC)Ccpcz
HET Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
1.13×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
ICS
IMPC
1.49×10-06
Tonsl
Tonslem1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.40×10-06
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology LVIDs
Echo
MRC Harwell
IMPC
2.44×10-06
Grem2
Grem2em1(IMPC)Bay
HET   Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
3.01×10-06
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
MARC
IMPC
3.19×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM   Early adult dilated heart left ventricle End-Systolic Diameter
Echo
BCM
IMPC
4.13×10-06
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET Late adult decreased heart left ventricle size LVAWd
Echo
ICS
IMPC
4.82×10-06
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
4.90×10-06
Calb1
Calb1em1(IMPC)Ccpcz
HOM Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
CCP-IMG
IMPC
5.45×10-06
Hycc1
Hycc1em1(IMPC)Ccpcz
HOM   Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
CCP-IMG
IMPC
6.74×10-06
Ints6l
Ints6lem1(IMPC)Marc
HOM Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
8.58×10-06
Xrcc5
Xrcc5em1(IMPC)Ccpcz
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
9.80×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
9.90×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
9.94×10-06
Aoc1
Aoc1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
HMGU
IMPC
1.44×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
1.47×10-05
Man1b1
Man1b1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
1.48×10-05
Prdm8
Prdm8em1(IMPC)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
CCP-IMG
IMPC
1.49×10-05
Atg4d
Atg4dem1(IMPC)Marc
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
1.51×10-05
Cdc123
Cdc123tm1b(KOMP)Wtsi
HET   Early adult abnormal heart left ventricle morphology LVIDs
Echo
HMGU
IMPC
1.62×10-05
Abitram
Abitramtm1b(EUCOMM)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
1.64×10-05
Eftud2
Eftud2tm1b(KOMP)Wtsi
HET   Late adult abnormal heart left ventricle morphology LVIDs
Echo
ICS
IMPC
1.73×10-05
Ppp3cb
Ppp3cbem1(IMPC)Ccpcz
HOM   Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
CCP-IMG
IMPC
1.89×10-05
Kdm2b
Kdm2bem1(IMPC)Marc
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
1.93×10-05
Dusp7
Dusp7tm1(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
1.95×10-05
Trim37
Trim37em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
1.96×10-05
Snx25
Snx25tm1b(KOMP)Wtsi
HET Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
2.01×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
2.06×10-05
Ube2z
Ube2zem1(IMPC)Marc
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
2.18×10-05
Dnd1
Dnd1em1(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.23×10-05
Prmt6
Prmt6em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
2.33×10-05
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
BCM
IMPC
2.38×10-05
Wars1
Wars1tm1b(EUCOMM)Hmgu
HET   Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
2.39×10-05
Fzd8
Fzd8em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.41×10-05
Tyk2
Tyk2tm2b(EUCOMM)Hmgu
HOM   Late adult decreased heart left ventricle size LVPWs
Echo
HMGU
IMPC
2.48×10-05
Ufm1
Ufm1em1(IMPC)Marc
HET Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
2.56×10-05
Slc2a12
Slc2a12em2(IMPC)Bay
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
2.79×10-05
Il17rd
Il17rdtm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
MRC Harwell
IMPC
2.89×10-05
Vav2
Vav2em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
3.07×10-05
Phf21b
Phf21bem1(IMPC)Marc
HOM Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
3.09×10-05
Col11a1
Col11a1em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
3.26×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal heart left ventricle morphology LVIDd
Echo
ICS
IMPC
3.41×10-05
Rxfp3
Rxfp3em1(IMPC)Bay
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
BCM
IMPC
3.81×10-05
Abcg8
Abcg8tm1b(KOMP)Wtsi
HOM   Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
CCP-IMG
IMPC
4.61×10-05
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi
HET Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
4.62×10-05
Phf8
Phf8tm1dIcs
HOM Early adult abnormal heart left ventricle morphology LVIDd
Echo
ICS
IMPC
4.65×10-05
Thra
Thratm1b(EUCOMM)Wtsi
HET   Late adult abnormal heart left ventricle morphology LVIDs
Echo
ICS
IMPC
4.76×10-05
Apol10b
Apol10btm1b(KOMP)Wtsi
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.03×10-05
Prdm15
Prdm15tm1b(EUCOMM)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.15×10-05
Lrig3
Lrig3em1(IMPC)Ccpcz
HOM   Early adult abnormal heart left ventricle morphology End-Diastolic Diameter
Echo
CCP-IMG
IMPC
5.34×10-05
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.42×10-05
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM   Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
5.46×10-05
Skil
Skiltm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.57×10-05
Adipor1
Adipor1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle morphology End-Systolic Diameter
Echo
MRC Harwell
IMPC
5.81×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.84×10-05
Ccdc83
Ccdc83em1(IMPC)Marc
HOM   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
5.91×10-05
Rxfp3
Rxfp3em1(IMPC)Bay
HOM   Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
5.93×10-05
Eddm3b
Eddm3btm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
MARC
IMPC
6.15×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
6.18×10-05
Pcdhgc3
Pcdhgc3em1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
6.43×10-05
Btbd8
Btbd8em1(IMPC)Ccpcz
HOM Early adult increased heart left ventricle size LVAWd
Echo
CCP-IMG
IMPC
7.61×10-05
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDs
Echo
BCM
IMPC
8.10×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HET   Early adult decreased heart left ventricle size LVAWd
Echo
MARC
IMPC
8.13×10-05
Emc4
Emc4tm1(KOMP)Wtsi
HET Early adult decreased heart left ventricle size LVPWs
Echo
MARC
IMPC
8.24×10-05
Ncam2
Ncam2tm1b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
ICS
IMPC
8.28×10-05
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM   Early adult abnormal heart left ventricle morphology LVIDs
Echo
CCP-IMG
IMPC
8.47×10-05
Arhgap40
Arhgap40tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
9.12×10-05
Acot12
Acot12em1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
9.31×10-05
Atad5
Atad5em1(IMPC)Bay
HET Early adult increased heart left ventricle size LVAWd
Echo
BCM
IMPC
9.44×10-05
Ap1ar
Ap1artm2b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
9.74×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

4.02% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (91/2265)

1.76% females (41/2325) 1.52% males (31/2042)

Select a parameter    



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