Genes Phenotypes

Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal left ventricle morphology,  abnormal LV
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 96

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter MRC Harwell | IMPC 2.53×10-21
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs MRC Harwell | IMPC 5.63×10-11
Ints6l
Ints6lem1(IMPC)Marc 		HEM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 3.47×10-09
Slc25a1
Slc25a1tm1b(EUCOMM)Wtsi 		HET postnatal decreased heart left ventricle size Echo | LVAWd BCM | IMPC 6.84×10-09
Bbs5
Bbs5tm1b(EUCOMM)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter MRC Harwell | IMPC 1.01×10-08
Suv39h2
Suv39h2em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.45×10-08
Ints6l
Ints6lem1(IMPC)Marc 		HEM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.08×10-08
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 4.47×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM postnatal increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 7.16×10-08
Ndufs7
Ndufs7tm1b(EUCOMM)Hmgu 		HET postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 1.01×10-07
Fzd8
Fzd8em1(IMPC)Bay 		HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.54×10-07
Ints6l
Ints6lem1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.83×10-07
Phf21b
Phf21bem1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 4.04×10-07
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.86×10-07
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi 		HET postnatal dilated heart left ventricle Echo | LVIDs BCM | IMPC 1.84×10-06
Slc10a2
Slc10a2tm1b(KOMP)Mbp 		HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.62×10-06
Ap1ar
Ap1artm2b(EUCOMM)Hmgu 		HOM postnatal dilated heart left ventricle Echo | End-Diastolic Diameter BCM | IMPC 3.39×10-06
Fzd8
Fzd8em1(IMPC)Bay 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 5.06×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi 		HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 5.32×10-06
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 5.46×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 5.52×10-06
Golt1b
Golt1btm1b(EUCOMM)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 7.62×10-06
Vav2
Vav2em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.01×10-05
Kdm2b
Kdm2bem1(IMPC)Marc 		HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.19×10-05
Prmt6
Prmt6em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.20×10-05
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM postnatal dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 1.22×10-05
Apol10b
Apol10btm1b(KOMP)Wtsi 		HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.22×10-05
Rnf10
Rnf10em1(IMPC)Bay 		HOM postnatal increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.23×10-05
Cdk5rap3
Cdk5rap3tm1b(EUCOMM)Hmgu 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.38×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.40×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 1.60×10-05
Ccdc83
Ccdc83em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.74×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.01×10-05
Aars2
Aars2tm1(KOMP)Wtsi 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 2.15×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.35×10-05
Ube2z
Ube2zem1(IMPC)Marc 		HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.57×10-05
Rcn3
Rcn3tm1b(EUCOMM)Hmgu 		HET postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 2.69×10-05
Pard3b
Pard3btm1b(EUCOMM)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.73×10-05
Esr2
Esr2em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.36×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi 		HET postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.45×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 3.70×10-05
Scaper
Scapertm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 3.81×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM postnatal abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.11×10-05
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.78×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu 		HOM postnatal decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.74×10-05
Pde4dip
Pde4diptm1b(KOMP)Wtsi 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 6.59×10-05
Trim37
Trim37em1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVPWs MARC | IMPC 7.21×10-05
Kcns2
Kcns2em1(IMPC)Bay 		HOM postnatal abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 7.27×10-05
Ascc2
Ascc2tm1b(EUCOMM)Wtsi 		HET postnatal decreased heart left ventricle size Echo | LVAWd BCM | IMPC 7.47×10-05
Itm2c
Itm2ctm1b(EUCOMM)Wtsi 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.53×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.67×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi 		HOM postnatal dilated heart left ventricle Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc 		HOM postnatal decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.97×10-05
Ift172
Ift172tm2b(EUCOMM)Hmgu 		HET postnatal abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 8.02×10-05
Zfp235
Zfp235tm1b(KOMP)Wtsi 		HOM postnatal abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 9.60×10-05
Gpr39
Gpr39em1(IMPC)Bay 		HOM postnatal dilated heart left ventricle Echo | LVIDd BCM | IMPC 9.68×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

3.96% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (52/1313)

3.54% females (46/1299) 4.49% males (46/1024)

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