Genes Phenotypes

Phenotype: abnormal heart left ventricle morphology

Definition
any structural anomaly of the left lower chamber of the heart
Synonyms
LV abnormality,  abnormal left ventricle morphology,  abnormal LV
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle morphology

Total number of significant genotype-phenotype associations: 88

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM Early adult dilated heart left ventricle Echo | End-Systolic Diameter MRC Harwell | IMPC 2.70×10-21
Ints6l
Ints6lem1(IMPC)Marc 		HEM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 3.47×10-09
Suv39h2
Suv39h2em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.45×10-08
Ints6l
Ints6lem1(IMPC)Marc 		HEM Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.08×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size Echo | LVAWd MRC Harwell | IMPC 8.36×10-08
Slc10a2
Slc10a2tm1b(KOMP)Mbp 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.30×10-07
Ints6l
Ints6lem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.83×10-07
Phf21b
Phf21bem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 4.04×10-07
Prdm4
Prdm4tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 4.58×10-07
Apol10b
Apol10btm1b(KOMP)Wtsi 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 1.08×10-06
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi 		HET Early adult dilated heart left ventricle Echo | LVIDs BCM | IMPC 1.48×10-06
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 2.60×10-06
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 3.77×10-06
Dsg2
Dsg2tm1b(EUCOMM)Wtsi 		HOM Early adult dilated heart left ventricle Echo | End-Systolic Diameter BCM | IMPC 4.39×10-06
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.78×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 5.52×10-06
Hmcn2
Hmcn2tm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 7.46×10-06
Col1a2
Col1a2tm1b(EUCOMM)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDs BCM | IMPC 7.61×10-06
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 7.78×10-06
Vav2
Vav2em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.01×10-05
Golt1b
Golt1btm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.10×10-05
Kdm2b
Kdm2bem1(IMPC)Marc 		HET Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.19×10-05
Prmt6
Prmt6em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.20×10-05
Rxfp3
Rxfp3em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 1.21×10-05
Cdk5rap3
Cdk5rap3tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.36×10-05
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd HMGU | IMPC 1.38×10-05
Fzd8
Fzd8em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs BCM | IMPC 1.40×10-05
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 1.60×10-05
Ccdc83
Ccdc83em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.74×10-05
Lep
Leptm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd BCM | IMPC 1.93×10-05
Sirt1
Sirt1tm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd MRC Harwell | IMPC 1.95×10-05
Aoc1
Aoc1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.06×10-05
Aars2
Aars2tm1(KOMP)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDd MARC | IMPC 2.15×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 2.35×10-05
Rnf10
Rnf10em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.53×10-05
Ube2z
Ube2zem1(IMPC)Marc 		HET Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 2.57×10-05
Pard3b
Pard3btm1b(EUCOMM)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 2.73×10-05
Esr2
Esr2em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.36×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 3.45×10-05
Aak1
Aak1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDd ICS | IMPC 3.80×10-05
Scaper
Scapertm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs ICS | IMPC 3.81×10-05
Kcns2
Kcns2em1(IMPC)Bay 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Diastolic Diameter BCM | IMPC 3.88×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu 		HOM Early adult abnormal heart left ventricle morphology Echo | End-Systolic Diameter MRC Harwell | IMPC 4.39×10-05
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 4.78×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 5.74×10-05
Trim37
Trim37em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVPWs MARC | IMPC 7.21×10-05
Itm2c
Itm2ctm1b(EUCOMM)Wtsi 		HET Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.47×10-05
Ascc2
Ascc2tm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 7.47×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs HMGU | IMPC 7.70×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi 		HOM Early adult abnormal heart left ventricle morphology Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp1r14d
Ppp1r14dtm1b(KOMP)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDs MARC | IMPC 7.82×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 7.97×10-05
Fmnl3
Fmnl3tm1b(KOMP)Wtsi 		HOM Early adult dilated heart left ventricle Echo | LVIDs BCM | IMPC 8.63×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

3.10% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle morphology (47/1518)

2.72% females (41/1505) 3.31% males (41/1237)

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