Phenotype: shortened QT interval

Definition
decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Synonyms
decreased QT interval,  reduced QT interval,  short QT
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with shortened QT interval

Total number of significant genotype-phenotype associations: 32

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Dnajc5b
Dnajc5btm1b(EUCOMM)Hmgu
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 2.46×10-14
Sgce
Sgceem1(IMPC)H
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 9.92×10-11
Hcn1
Hcn1em1(IMPC)H
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 1.04×10-08
Rgs2
Rgs2em1(IMPC)H
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 1.52×10-08
Slc10a4
Slc10a4tm1b(KOMP)Wtsi
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 8.16×10-07
Klhdc7b
Klhdc7bem1(IMPC)H
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 1.15×10-06
Gkap1
Gkap1tm2b(EUCOMM)Hmgu
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 1.28×10-06
Rprd2
Rprd2em1(IMPC)J
HET   Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 1.49×10-06
Thra
Thratm1b(EUCOMM)Wtsi
HET Late adult shortened QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 2.18×10-06
Rbm6
Rbm6em1(IMPC)J
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 3.34×10-06
Kctd19
Kctd19em1(IMPC)J
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 4.34×10-06
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 6.45×10-06
Wdr70
Wdr70em1(IMPC)J
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 7.64×10-06
Dyrk1b
Dyrk1btm1b(EUCOMM)Wtsi
HET Late adult shortened QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 1.05×10-05
Ptgr1
Ptgr1tm1b(EUCOMM)Wtsi
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 1.25×10-05
Clk2
Clk2em1(IMPC)Bay
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 1.49×10-05
Mindy2
Mindy2em1(IMPC)H
HOM   Late adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 1.71×10-05
Coro2b
Coro2bem1(IMPC)J
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 1.71×10-05
Rnf144b
Rnf144btm1b(EUCOMM)Hmgu
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 1.85×10-05
Gnb1
Gnb1em1(IMPC)Bay
HET   Early adult shortened QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 2.39×10-05
Cib1
Cib1tm1b(EUCOMM)Hmgu
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 2.77×10-05
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 3.02×10-05
Klhl12
Klhl12em1(IMPC)Tcp
HOM   Late adult shortened QT interval Electrocardiogram (ECG) | QTc TCP | IMPC 3.23×10-05
Crcp
Crcpem1(IMPC)J
HET Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 3.66×10-05
Slc8a3
Slc8a3tm1.1(KOMP)Vlcg
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 4.53×10-05
Dennd1a
Dennd1aem1(IMPC)Mbp
HET Early adult shortened QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 5.48×10-05
Shisa9
Shisa9em1(IMPC)H
HOM Early adult shortened QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 7.10×10-05
Ap2a1
Ap2a1em1(IMPC)J
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 7.14×10-05
Tmem256
Tmem256tm1.1(KOMP)Vlcg
HOM   Early adult shortened QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 8.81×10-05

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 The way we measure

 Phenotype associations stats

0.65% of tested genes with null mutations on a B6N genetic background have a phenotype association to shortened QT interval (29/4462)

0.27% females (12/4422) 0.16% males (7/4410)

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