Phenotype: prolonged PR interval

Definition
increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
Synonyms
prolonged PR-interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged PR interval

Total number of significant genotype-phenotype associations: 34

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Usp53
Usp53em1(IMPC)Tcp
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
TCP
IMPC
8.33×10-11
Ctag2l2
Ctag2l2tm1.1(KOMP)Vlcg
HEM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
1.15×10-10
Cacna1f
Cacna1ftm1.1(KOMP)Vlcg
HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
2.48×10-09
Atrn
Atrntm1.1(KOMP)Vlcg
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
6.98×10-09
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.25×10-08
Grtp1
Grtp1tm1b(EUCOMM)Hmgu
HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
TCP
IMPC
3.54×10-07
Gpr50
Gpr50tm1.1(KOMP)Vlcg
HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
4.33×10-07
Ugt2a1
Ugt2a1em1(IMPC)Bay
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
BCM
IMPC
6.10×10-07
Mtrr
Mtrrem1(IMPC)Bay
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
BCM
IMPC
8.97×10-07
Cacna1f
Cacna1ftm1.1(KOMP)Vlcg
HEM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
1.57×10-06
Plekha8
Plekha8tm1b(KOMP)Wtsi
HET   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
1.75×10-06
Slc9a1
Slc9a1em1(IMPC)Mbp
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
5.84×10-06
Klhdc2
Klhdc2tm1b(EUCOMM)Hmgu
HET   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
8.47×10-06
Ubxn6
Ubxn6em1(IMPC)Bay
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
BCM
IMPC
9.00×10-06
Arih2
Arih2tm1.1(KOMP)Vlcg
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
9.46×10-06
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
1.42×10-05
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.18×10-05
Usp22
Usp22tm1b(KOMP)Wtsi
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.58×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
TCP
IMPC
2.65×10-05
Rgs2
Rgs2em1(IMPC)H
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.40×10-05
Padi4
Padi4em1(IMPC)Mbp
HOM   Late adult prolonged PR interval PR
Electrocardiogram (ECG)
UC Davis
IMPC
3.49×10-05
Mindy4
Mindy4em1(IMPC)H
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.31×10-05
Spata31d1d
Spata31d1dem1(IMPC)J
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
JAX
IMPC
5.56×10-05
Tmco5
Tmco5tm1b(KOMP)Wtsi
HOM Late adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
5.70×10-05
Plaur
Plaurem1(IMPC)H
HOM Late adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.37×10-05
Focad
Focadem1(IMPC)Bay
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
BCM
IMPC
7.90×10-05
Zfp69
Zfp69tm1b(EUCOMM)Hmgu
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
HMGU
IMPC
8.52×10-05
Gdf15
Gdf15tm1b(KOMP)Wtsi
HOM   Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
8.76×10-05
Smo
Smotm1b(KOMP)Wtsi
HET Early adult prolonged PR interval PR
Electrocardiogram (ECG)
BCM
IMPC
8.94×10-05
Rhobtb1
Rhobtb1em2(IMPC)Ccpcz
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
CCP-IMG
IMPC
9.04×10-05
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged PR interval PR
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.44×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.58% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged PR interval (30/5201)

0.31% females (16/5147) 0.16% males (8/5132)

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