MP:0003394 (increased cardiac output) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: increased cardiac output

Definition

greater than normal blood volume pumped by each ventricle per minute

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 4

Gene / Allele	Zygosity	Life Stage	Phenotype	Procedure \| Parameter	Phenotyping Center \| Source	P Value
Shox2 Shox2^em1(IMPC)Bay	HET	Early adult	increased cardiac output	Echo \| Cardiac Output	BCM \| IMPC	5.03×10^-06
Ces1a Ces1a^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased cardiac output	Echo \| Cardiac Output	BCM \| IMPC	1.92×10^-05
AW549877 AW549877^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased cardiac output	Echo \| Cardiac Output	BCM \| IMPC	2.23×10^-05
Lep Lep^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased cardiac output	Echo \| Cardiac Output	BCM \| IMPC	4.60×10^-05

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Procedure
Echo

0.30% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac output (4/1346)

0.07% females (1/1339) 0.19% males (2/1062)

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