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Phenotype: decreased cardiac output

Definition
reduction in the blood volume pumped by each ventricle per minute
Synonyms
reduced cardiac output
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased cardiac output

Total number of significant genotype-phenotype associations: 24

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Ap4e1
Ap4e1tm1b(KOMP)Wtsi 		HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 4.56×10-11
Tent5a
Tent5aem1(IMPC)Ccpcz 		HOM Early adult decreased cardiac output Echo | Cardiac Output CCP-IMG | IMPC 1.01×10-10
Nr1d1
Nr1d1tm1(KOMP)Vlcg 		HOM   Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 5.22×10-10
Nek1
Nek1em1(IMPC)Bay 		HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 9.50×10-09
Golt1b
Golt1btm1b(EUCOMM)Wtsi 		HOM Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 1.32×10-08
Lrrfip1
Lrrfip1tm1.1(KOMP)Wtsi 		HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 1.66×10-07
Ltn1
Ltn1tm1b(EUCOMM)Hmgu 		HOM   Early adult decreased cardiac output Echo | Cardiac Output CCP-IMG | IMPC 7.64×10-07
Kcns2
Kcns2em1(IMPC)Bay 		HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 2.43×10-06
Map3k12
Map3k12tm1b(EUCOMM)Hmgu 		HET Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 5.72×10-06
Rps6kc1
Rps6kc1tm1b(EUCOMM)Wtsi 		HOM Early adult decreased cardiac output Echo | Cardiac Output BCM | IMPC 7.18×10-06
Yae1d1
Yae1d1tm1b(EUCOMM)Hmgu 		HET Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 7.78×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu 		HOM   Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 1.02×10-05
Pcdh20
Pcdh20em1(IMPC)H 		HOM   Late adult decreased cardiac output Echo | Cardiac Output MRC Harwell | IMPC 1.55×10-05
Ndrg4
Ndrg4tm1b(KOMP)Wtsi 		HOM   Early adult decreased cardiac output Echo | Cardiac Output MRC Harwell | IMPC 3.07×10-05
Vgll4
Vgll4tm1b(EUCOMM)Hmgu 		HET Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 3.63×10-05
Cnpy2
Cnpy2em1(IMPC)Wtsi 		HOM   Early adult decreased cardiac output Echo | Cardiac Output CCP-IMG | IMPC 5.09×10-05
Mcu
Mcutm1b(EUCOMM)Hmgu 		HET   Early adult decreased cardiac output Echo | Cardiac Output MRC Harwell | IMPC 5.59×10-05
Col11a2
Col11a2tm1b(KOMP)Wtsi 		HET Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 5.94×10-05
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi 		HET   Early adult decreased cardiac output Echo | Cardiac Output HMGU | IMPC 8.24×10-05
BC055324
BC055324tm1b(EUCOMM)Hmgu 		HET   Early adult decreased cardiac output Echo | Cardiac Output MRC Harwell | IMPC 8.49×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased cardiac output (20/1284)

0.63% females (8/1277) 0.70% males (7/1000)

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