Phenotype: prolonged QT interval

Definition
increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Synonyms
increased QT interval,  widened QT interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QT interval

Total number of significant genotype-phenotype associations: 24

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Ypel2
Ypel2em1(IMPC)Tcp
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc TCP | IMPC 5.56×10-14
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 9.13×10-11
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 5.03×10-08
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 3.86×10-07
Dym
Dymem1(IMPC)Tcp
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc TCP | IMPC 1.41×10-06
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 1.74×10-06
Rwdd3
Rwdd3tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 2.85×10-06
Col6a3
Col6a3em1(IMPC)Tcp
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc TCP | IMPC 3.76×10-06
Zfp804a
Zfp804aem1(IMPC)Tcp
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc TCP | IMPC 5.62×10-06
Yju2
Yju2tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 1.08×10-05
Foxk2
Foxk2em1(IMPC)J
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 1.55×10-05
Amigo1
Amigo1tm1.1(KOMP)Vlcg
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 1.78×10-05
Boc
Boctm1b(KOMP)Wtsi
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc MRC Harwell | IMPC 3.09×10-05
Sh3tc1
Sh3tc1tm1b(EUCOMM)Hmgu
HOM   Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 3.25×10-05
Cav1
Cav1em2(IMPC)Ics
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 3.44×10-05
Pdk2
Pdk2em1(IMPC)Mbp
HOM   Late adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 4.16×10-05
Mfn2
Mfn2tm1b(EUCOMM)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 4.49×10-05
Cd36
Cd36em1(IMPC)Mbp
HOM Late adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 5.87×10-05
Mon1a
Mon1aem1(IMPC)J
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 6.05×10-05
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET   Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 7.42×10-05
Tfeb
Tfebtm1b(EUCOMM)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 7.81×10-05
Cenpe
Cenpetm1b(EUCOMM)Hmgu
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 8.30×10-05
Mllt10
Mllt10em1(IMPC)Mbp
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 8.38×10-05
Ranbp10
Ranbp10tm1.1(KOMP)Vlcg
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 9.06×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.54% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QT interval (24/4462)

0.14% females (6/4422) 0.34% males (15/4410)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter