Phenotype: prolonged QT interval

Definition
increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
Synonyms
widened QT interval,  long QT syndrome,  increased QT interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QT interval

Total number of significant genotype-phenotype associations: 15

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 1.21×10-12
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 5.51×10-07
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 3.88×10-06
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 5.26×10-06
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 6.00×10-06
Fbn2
Fbn2em1(IMPC)Rbrc
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 7.45×10-06
Rwdd3
Rwdd3tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 9.57×10-06
Amigo1
Amigo1tm1.1(KOMP)Vlcg
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 2.48×10-05
Mcam
Mcamtm1.1(KOMP)Wtsi
HOM Early adult prolonged QT interval Electrocardiogram (ECG) | QTc UC Davis | IMPC 2.48×10-05
Yju2
Yju2tm1b(KOMP)Wtsi
HET Early adult prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 2.83×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.31% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QT interval (10/3203)

0.25% females (8/3163) 0.22% males (7/3169)

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