Phenotype: prolonged QT interval

Definition increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave

Synonyms
  • widened QT interval
  • widened QT interval
  • long QT syndrome
  • long QT syndrome
  • increased QT interval
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Phenotype associations stats

2.27% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QT interval (40/1764)

2.10% females (37/1760) 2.16% males (38/1763)

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Gene variants with prolonged QT interval

Total number of significant genotype-phenotype associations: 77

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Tfr2
Tfr2em1Rbrc
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.02E-16
Ddrgk1
Ddrgk1tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 2.19E-16
Atp13a2
Atp13a2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 4.96E-16
Gal
Galtm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 6.84E-16
Dctn2
Dctn2tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.72E-15
Psmf1
Psmf1tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 2.9E-15
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 2.99E-15
Slc2a2
Slc2a2tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 3.56E-15
Edn2
Edn2tm1b(KOMP)Mbp
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 4.11E-15
Ppp4r1
Ppp4r1em1Rbrc
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.47E-14
Gucy2c
Gucy2cem1Rbrc
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 2.29E-14
Tgm3
Tgm3tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 3.56E-14
Trpc5
Trpc5tm1b(KOMP)Wtsi
HOM Female postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 4.19E-14
Nin
Nintm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 4.69E-14
Kif2c
Kif2ctm1.1(KOMP)Vlcg
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.88E-13
Adcyap1r1
Adcyap1r1tm1e.1(KOMP)Wtsi
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.96E-13
Marco
Marcotm2b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 3.69E-13
Trpc5
Trpc5tm1b(KOMP)Wtsi
HEM Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 6.29E-13
Laptm4a
Laptm4atm1b(EUCOMM)Hmgu
HOM Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 1.4E-12
Npsr1
Npsr1tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.52E-12
Pdyn
Pdynem1Rbrc
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 4.34E-11
Ube2g1
Ube2g1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 5.06E-11
Vps39
Vps39tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 5.74E-11
Uts2
Uts2tm1b(KOMP)Wtsi
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.51E-10
Cck
Ccktm2b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 2.49E-10
Osbpl11
Osbpl11tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 3.97E-10
Sept5
Sept5tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 5.99E-10
Hoxa2
Hoxa2tm1b(EUCOMM)Wtsi
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 6.88E-10
Klrb1
Klrb1tm1b(EUCOMM)Wtsi
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 1.68E-9
Tyms
Tymstm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 3.16E-9
Hbb-bh2
Hbb-bh2tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 6.33E-9
Apln
Aplntm1b(KOMP)Wtsi
HOM Female postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 1.97E-7
Iah1
Iah1tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 6.45E-6
Rwdd3
Rwdd3tm1b(KOMP)Wtsi
HET Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 1.09E-5
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc JAX | IMPC 1.11E-5
Hbq1a
Hbq1atm1.1(KOMP)Vlcg
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 3.39E-5
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Female postnatal prolonged QT interval Electrocardiogram (ECG) | QTc BCM | IMPC 6.1E-5
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 6.9E-5
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc ICS | IMPC 6.9E-5
Mfn2
Mfn2tm1b(EUCOMM)Wtsi
HET Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 7.04E-5
Clspn
Clspntm1(KOMP)Vlcg
HET Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc RBRC | IMPC 7.92E-5
Rps26
Rps26tm2b(EUCOMM)Hmgu
HOM Female Male postnatal prolonged QT interval Electrocardiogram (ECG) | QTc HMGU | IMPC 9.16E-5

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