Phenotype: decreased heart weight

Definition
less than average weight of the heart compared to controls
Synonyms
reduced heart weight
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 77

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Ghrh
Ghrhtm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.05×10-20
Lepr
Leprtm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
3.64×10-19
Gh
Ghtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
2.49×10-16
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
1.00×10-14
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
6.23×10-14
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.54×10-11
Pdcd6ip
Pdcd6ipem1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.55×10-11
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
8.17×10-11
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
WTSI
IMPC
2.70×10-10
Camk1d
Camk1dem1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.86×10-10
Duox2
Duox2em1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.99×10-08
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
3.51×10-08
Ppp1r12b
Ppp1r12bem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
5.05×10-08
Gabrg2
Gabrg2em1(IMPC)Mbp
HET Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
8.97×10-08
Ppia
Ppiaem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.49×10-07
Tsnax
Tsnaxem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
1.52×10-07
Naa10
Naa10em1(IMPC)Mbp
HEM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
3.22×10-07
Tenm4
Tenm4em1(IMPC)Tcp
HOM Late adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
4.01×10-07
Rnf14
Rnf14em1(IMPC)Ccpcz
HOM Early adult decreased heart weight Heart weight
Heart Weight
CCP-IMG
IMPC
5.09×10-07
Nucb1
Nucb1em1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.23×10-06
Dytn
Dytnem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
2.76×10-06
Atp8b1
Atp8b1em1(IMPC)Tcp
HOM Late adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
2.93×10-06
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
ICS
IMPC
3.07×10-06
Fndc3a
Fndc3aem1(IMPC)Tcp
HOM Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
3.38×10-06
Elovl5
Elovl5em1(IMPC)Tcp
HOM Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
4.33×10-06
Ube3c
Ube3ctm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
RBRC
IMPC
4.33×10-06
Fbxo11
Fbxo11Jf
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
4.38×10-06
Topors
Toporsem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
5.12×10-06
Exoc3l2
Exoc3l2em1(IMPC)J
HET Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
6.55×10-06
Tmem248
Tmem248tm1.1(KOMP)Vlcg
HOM   Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
7.98×10-06
Cisd2
Cisd2tm1a(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
9.06×10-06
Trh
Trhem1(IMPC)Tcp
HOM Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
9.21×10-06
Ccdc93
Ccdc93em1(IMPC)J
HET Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
9.35×10-06
Dapl1
Dapl1em1(IMPC)Kmpc
HOM Early adult decreased heart weight Heart weight
Heart Weight
KMPC
IMPC
9.36×10-06
Hrh4
Hrh4tm1b(EUCOMM)Hmgu
HOM   Early adult decreased heart weight Heart weight
Heart Weight
ICS
IMPC
1.07×10-05
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.32×10-05
Rab28
Rab28em1(IMPC)J
HOM   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
1.80×10-05
Dpp8
Dpp8em1(IMPC)J
HOM   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
2.09×10-05
Coq2
Coq2tm1b(EUCOMM)Hmgu
HET Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.12×10-05
Rab39b
Rab39bem1(IMPC)Tcp
HEM Late adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
2.17×10-05
Neurl4
Neurl4em1(IMPC)Mbp
HOM Late adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.55×10-05
Tle4
Tle4em1(IMPC)Mbp
HOM   Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.14×10-05
Ythdc2
Ythdc2em1(IMPC)Bay
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
3.23×10-05
Eif2b5
Eif2b5tm1a(EUCOMM)Wtsi
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
ICS
EuroPhenome
3.66×10-05
Trim10
Trim10em1(IMPC)J
HOM   Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
3.73×10-05
Optn
Optntm1a(EUCOMM)Wtsi
HET Early adult decreased heart weight Heart weight
Heart weight/tibia length
HMGU
EuroPhenome
4.01×10-05
Acta2
Acta2em1(IMPC)H
HOM Early adult decreased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
4.13×10-05
Mc3r
Mc3rem1(IMPC)Mbp
HOM Early adult decreased heart weight Heart weight
Heart Weight
UC Davis
IMPC
4.14×10-05
Fundc1
Fundc1tm1c(KOMP)Wtsi
HEM Early adult decreased heart weight Heart weight
Heart Weight
WTSI
IMPC
4.25×10-05
Mir96
Mir96Dmdo
HOM Early adult decreased heart weight Heart weight
Heart weight/tibia length
WTSI
MGP
4.50×10-05
Arl4d
Arl4dtm1a(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Dissection
WTSI
MGP
4.52×10-05
Cfap20dc
Cfap20dcem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
4.75×10-05
Clcn1
Clcn1em1(IMPC)Mbp
HOM   Early adult decreased heart weight Heart weight
Organ Weight
UC Davis
IMPC
4.75×10-05
Zfp593
Zfp593em1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
4.83×10-05
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM Early adult decreased heart weight Heart weight
Heart Weight
MARC
IMPC
4.98×10-05
Nup153
Nup153em1(IMPC)J
HET Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
6.24×10-05
Krt26
Krt26em1(IMPC)Kmpc
HOM Late adult decreased heart weight Heart weight
Heart Weight
KMPC
IMPC
7.69×10-05
Vps25
Vps25tm1.1(KOMP)Vlcg
HET Early adult decreased heart weight Heart weight
Heart Weight
TCP
IMPC
8.31×10-05
Kctd1
Kctd1em1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
8.35×10-05
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
HMGU
IMPC
8.95×10-05
Mast1
Mast1em1(IMPC)Marc
HOM Early adult decreased heart weight Heart weight
Heart Weight
MARC
IMPC
9.39×10-05
Pcyox1l
Pcyox1lem1(IMPC)J
HOM Early adult decreased heart weight Heart weight
Heart Weight
JAX
IMPC
9.69×10-05
Adgrg7
Adgrg7tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart weight Heart weight
Heart Weight
BCM
IMPC
9.83×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.84% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (63/7541)

0.30% females (23/7555) 0.62% males (47/7536)

Select a parameter    



The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter