Phenotype: decreased heart weight

Definition
less than average weight of the heart compared to controls
Synonyms
reduced heart weight
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased heart weight

Total number of significant genotype-phenotype associations: 59

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight WTSI | IMPC 5.54×10-11
Il2ra
Il2ratm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 2.15×10-09
Ghrhr
Ghrhrtm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 2.75×10-09
Kctd1
Kctd1em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 2.79×10-08
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.15×10-07
Trh
Trhem1(IMPC)Tcp
HOM postnatal decreased heart weight Heart Weight | Heart weight TCP | IMPC 1.18×10-07
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 6.70×10-07
Tlr4
Tlr4tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.80×10-06
Klhl29
Klhl29tm1b(EUCOMM)Hmgu
HOM postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 8.56×10-06
Snip1
Snip1tm1a(EUCOMM)Wtsi
HET postnatal decreased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 9.07×10-06
Acsl4
Acsl4tm1a(EUCOMM)Wtsi
HET postnatal decreased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 1.11×10-05
Dync1h1
Dync1h1tm1dIcs
HET postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 1.21×10-05
Ube3c
Ube3ctm1b(EUCOMM)Hmgu
HOM postnatal decreased heart weight Heart Weight | Heart weight RBRC | IMPC 1.22×10-05
Grin2d
Grin2dtm1a(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.25×10-05
Mmp9
Mmp9tm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 1.42×10-05
Eid2
Eid2em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 1.63×10-05
Dram1
Dram1tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.69×10-05
Cybrd1
Cybrd1tm1b(EUCOMM)Hmgu
HOM postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.82×10-05
Ly6g6d
Ly6g6dtm1b(EUCOMM)Hmgu
HOM postnatal decreased heart weight Heart Weight | Heart weight HMGU | IMPC 2.21×10-05
Coq2
Coq2tm1b(EUCOMM)Hmgu
HET postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.37×10-05
Elmod3
Elmod3em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 2.56×10-05
Rnf24
Rnf24em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 2.85×10-05
Nr1h3
Nr1h3tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.87×10-05
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight WTSI | IMPC 2.98×10-05
Fndc9
Fndc9tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 3.03×10-05
Cyp17a1
Cyp17a1tm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart Weight | Heart weight MARC | IMPC 3.15×10-05
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM postnatal decreased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 3.30×10-05
Zfp202
Zfp202em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 3.35×10-05
Mbtd1
Mbtd1tm2a(EUCOMM)Wtsi
HET postnatal decreased heart weight Heart Dissection | Heart weight WTSI | MGP 4.69×10-05
Pink1
Pink1tm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.72×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.35×10-05
P2rx4
P2rx4tm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.97×10-05
Pcyox1l
Pcyox1lem1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 6.02×10-05
Bbs5
Bbs5tm1b(EUCOMM)Wtsi
HOM postnatal decreased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 6.41×10-05
Prf1
Prf1tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.77×10-05
Ccdc57
Ccdc57tm1a(EUCOMM)Wtsi
HET postnatal decreased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 7.82×10-05
Kctd13
Kctd13em2(IMPC)Ics
HOM postnatal decreased heart weight Heart Weight | Heart weight ICS | IMPC 8.36×10-05
Vwa1
Vwa1tm1.1(KOMP)Vlcg
HOM postnatal decreased heart weight Heart Weight | Heart weight UC Davis | IMPC 8.71×10-05
Clstn2
Clstn2em1(IMPC)J
HOM postnatal decreased heart weight Heart Weight | Heart weight JAX | IMPC 9.82×10-05

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 The way we measure

 Phenotype associations stats

0.85% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased heart weight (39/4610)

0.53% females (24/4544) 0.77% males (35/4575)

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