Phenotype: increased heart weight

Definition
greater than average weight of the heart compared to controls
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 144

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
0.00
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
4.78×10-27
Fsd2
Fsd2em1(IMPC)Mbp
HOM Late adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.30×10-14
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
1.15×10-13
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
3.00×10-13
Gnas
Gnastm1Jop
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
7.03×10-12
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
4.48×10-11
Taco1
Taco1em1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
5.63×10-10
Tmem203
Tmem203em1(IMPC)H
HOM   Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
7.49×10-10
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.06×10-09
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.15×10-09
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.76×10-09
Kcng2
Kcng2em1(IMPC)Bay
HOM Early adult increased heart weight Heart weight
Heart Weight
BCM
IMPC
3.80×10-09
Rbm22
Rbm22em1(IMPC)Mbp
HET Late adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
4.45×10-09
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
5.81×10-09
Dbnl
Dbnltm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
8.00×10-09
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
1.01×10-08
Trappc2l
Trappc2lem1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.27×10-08
Pdp1
Pdp1em1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.77×10-08
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
1.92×10-08
Stx11
Stx11em1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.61×10-08
Ide
Idetm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
6.68×10-08
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
6.73×10-08
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Weight
BCM
IMPC
7.98×10-08
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
1.19×10-07
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
1.24×10-07
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
1.54×10-07
Lrrc41
Lrrc41em1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.75×10-07
Ywhaz
Ywhaztm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
1.83×10-07
Rap1gap2
Rap1gap2tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
3.12×10-07
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
4.74×10-07
Wdr47
Wdr47tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Dissection
WTSI
EuroPhenome
4.92×10-07
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Heart Weight
MARC
IMPC
5.44×10-07
Ppp2r5c
Ppp2r5cem1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
5.68×10-07
Mpv17
Mpv17em1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
5.87×10-07
Steap3
Steap3tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
6.10×10-07
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
6.88×10-07
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
6.88×10-07
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
7.02×10-07
Spns1
Spns1tm1e(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight
Heart weight/tibia length
ICS
EuroPhenome
1.01×10-06
2610507B11Rik
2610507B11Rikem1(IMPC)J
HET Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.29×10-06
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.30×10-06
Nos3
Nos3em1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
1.47×10-06
Kpna4
Kpna4em1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.60×10-06
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
1.60×10-06
Hcn1
Hcn1em1(IMPC)H
HOM Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
1.72×10-06
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
2.21×10-06
Stox2
Stox2tm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
2.33×10-06
Xpo1
Xpo1em1(IMPC)Mbp
HET Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.24×10-06
Rhbdf2
Rhbdf2Rhbdf2
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
3.25×10-06
Vsig4
Vsig4tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
3.49×10-06
Afg1l
Afg1lem1(IMPC)KMPC
HOM Late adult increased heart weight Heart weight
Heart Weight
KMPC
IMPC
3.97×10-06
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
4.21×10-06
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
5.24×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
5.42×10-06
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Early adult increased heart weight Heart weight
Heart Weight
MARC
IMPC
5.47×10-06
Cd36
Cd36em1(IMPC)Mbp
HOM Late adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
5.70×10-06
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
5.70×10-06
Plaat3
Plaat3em1(IMPC)Tcp
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
5.85×10-06
Tbl1xr1
Tbl1xr1tm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Heart Weight
HMGU
IMPC
5.87×10-06
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
6.00×10-06
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
6.10×10-06
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
6.20×10-06
Gda
Gdatm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
7.39×10-06
Pebp1
Pebp1em1(IMPC)Tcp
HOM   Late adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
7.82×10-06
Rasa1
Rasa1tm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
8.45×10-06
Erap1
Erap1tm2b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
KMPC
IMPC
8.46×10-06
Gorasp1
Gorasp1tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
8.56×10-06
Acvr1c
Acvr1ctm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
9.14×10-06
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
9.34×10-06
Secisbp2l
Secisbp2lem1(IMPC)J
HOM Late adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
9.35×10-06
Mir129-2
Mir129-2em1(IMPC)KMPC
HOM Late adult increased heart weight Heart weight
Heart Weight
KMPC
IMPC
1.23×10-05
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
1.45×10-05
Gimap8
Gimap8tm1.1(KOMP)Vlcg
HOM   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.48×10-05
Atg2b
Atg2bem1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.60×10-05
Mpdz
Mpdzem1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
1.60×10-05
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
1.61×10-05
Arhgef6
Arhgef6tm2e.1(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
1.69×10-05
Cdk12
Cdk12em1(IMPC)Tcp
HET Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
1.85×10-05
Cln6
Cln6tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
1.96×10-05
Arsj
Arsjem1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
2.03×10-05
Shisa6
Shisa6em1(IMPC)Tcp
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
2.11×10-05
Hivep1
Hivep1tm1(KOMP)Mbp
HET   Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
2.13×10-05
Taco1
Taco1em1(IMPC)J
HOM   Late adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
2.14×10-05
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
2.17×10-05
Zc3hc1
Zc3hc1tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
2.18×10-05
Slc16a2
Slc16a2tm1a(KOMP)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
2.51×10-05
Hddc2
Hddc2em1(IMPC)H
HOM Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.61×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
2.68×10-05
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
2.72×10-05
Ptgis
Ptgisem1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
2.82×10-05
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
2.84×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Dissection
WTSI
EuroPhenome
2.93×10-05
H2-M5
H2-M5tm1(KOMP)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
3.40×10-05
Cd36
Cd36em1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.43×10-05
Nox4
Nox4tm1.1Hwsc
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
HMGU
EuroPhenome
3.46×10-05
Mplkip
Mplkiptm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
3.50×10-05
Bbox1
Bbox1tm1b(KOMP)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
3.60×10-05
Tnks
Tnksem1(IMPC)Hmgu
HOM   Early adult increased heart weight Heart weight
Heart Weight
HMGU
IMPC
3.81×10-05
Dap
Daptm1a(KOMP)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
3.97×10-05
Phyh
Phyhtm1b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
4.27×10-05
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Dissection
WTSI
EuroPhenome
4.48×10-05
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
4.48×10-05
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
4.53×10-05
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
4.54×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
5.27×10-05
Mturn
Mturntm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
5.28×10-05
Nog
Nogem1(IMPC)Mbp
HET Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
5.32×10-05
Plpp3
Plpp3tm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
5.34×10-05
Cops7a
Cops7atm1b(KOMP)Mbp
HOM   Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
5.67×10-05
Dlg2
Dlg2tm1Dsb
HOM   Early adult increased heart weight Heart weight
Heart Dissection
WTSI
EuroPhenome
5.94×10-05
Lmna
Lmnatm1b(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
5.95×10-05
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart weight
Organ Weight
MRC Harwell
IMPC
5.96×10-05
Btg1
Btg1em1(IMPC)Mbp
HOM   Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.24×10-05
Specc1l
Specc1lem1(IMPC)J
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
6.35×10-05
Lox
Loxem1(IMPC)Mbp
HET Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
6.68×10-05
Ptpn5
Ptpn5tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
JAX
IMPC
6.71×10-05
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart weight
Heart Weight
ICS
IMPC
6.78×10-05
Cacna1c
Cacna1cem1(IMPC)Mbp
HET Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
7.33×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
WTSI
EuroPhenome
7.73×10-05
Ankrd12
Ankrd12tm1a(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
8.32×10-05
Erp44
Erp44tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
8.38×10-05
Zmynd8
Zmynd8tm1a(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight
Heart Dissection
WTSI
MGP
8.43×10-05
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM   Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
8.49×10-05
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Organ Weight
UC Davis
IMPC
8.51×10-05
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
8.81×10-05
Idh1
Idh1tm1b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Weight
TCP
IMPC
9.11×10-05
Spred1
Spred1em1(IMPC)Ccpcz
HOM   Early adult increased heart weight Heart weight
Heart Weight
CCP-IMG
IMPC
9.11×10-05
Pld4
Pld4em1(IMPC)Mbp
HOM   Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
9.12×10-05
Pon3
Pon3tm1b(KOMP)Wtsi
HOM Late adult increased heart weight Heart weight
Heart Weight
KMPC
IMPC
9.29×10-05
Crabp2
Crabp2em1(IMPC)Mbp
HOM Early adult increased heart weight Heart weight
Heart Weight
UC Davis
IMPC
9.40×10-05
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart weight/tibia length
MRC Harwell
EuroPhenome
9.53×10-05
Synj2
Synj2tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight
Heart Dissection
WTSI
EuroPhenome
9.53×10-05
Polb
Polbtm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart weight
Heart Weight
WTSI
IMPC
9.66×10-05
Etaa1
Etaa1em1(IMPC)Marc
HOM   Early adult increased heart weight Heart weight
Heart Weight
MARC
IMPC
9.91×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.98% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (133/6725)

0.32% females (21/6498) 1.45% males (94/6497)

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