MP:0002833 (increased heart weight) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Genes Phenotypes

Phenotype: increased heart weight

Definition

greater than average weight of the heart compared to controls

Significant gene associations The way we measure Phenotype stats

of tested genes

significant genes

tested genes

IMPC Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 121

Gene / Allele	Zygosity	Life Stage	Phenotype	Procedure \| Parameter	Phenotyping Center \| Source	P Value
Alpk3 Alpk3^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	0.00
Mybpc3 Mybpc3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	1.17×10^-19
Slc25a4 Slc25a4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	6.28×10^-19
Ndufs3 Ndufs3^{tm1a(EUCOMM)Wtsi}	HET	Early adult	increased heart weight	Heart Dissection \| Heart weight	WTSI \| EuroPhenome	8.31×10^-13
Gnas Gnas^tm1Jop	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	2.14×10^-11
Sik1 Sik1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	3.64×10^-11
Ric1 Ric1^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	6.73×10^-11
Ttc39a Ttc39a^{tm1b(KOMP)Mbp}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	1.91×10^-10
Rab19 Rab19^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	3.99×10^-10
Ash1l Ash1l^{tm2b(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	MARC \| IMPC	3.99×10^-09
Taco1 Taco1^em1(IMPC)J	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	6.07×10^-09
Tbl1xr1 Tbl1xr1^{tm1b(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	HMGU \| IMPC	8.53×10^-09
Lcn2 Lcn2^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	9.05×10^-09
Grm6 Grm6^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	1.57×10^-08
Srcin1 Srcin1^{tm1.1(KOMP)Vlcg}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	2.49×10^-08
Rap1gap2 Rap1gap2^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	3.62×10^-08
Cidec Cidec^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	HMGU \| EuroPhenome	5.10×10^-08
Ppp2r5c Ppp2r5c^em1(IMPC)Mbp	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	5.86×10^-08
Exd1 Exd1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	9.62×10^-08
Dynlrb2 Dynlrb2^{tm1a(KOMP)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	1.21×10^-07
Wdr45 Wdr45^em1(IMPC)J	HEM	Late adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	1.45×10^-07
Mir129-2 Mir129-2^{em1(IMPC)KMPC}	HOM	Late adult	increased heart weight	Heart Weight \| Heart weight	KMPC \| IMPC	1.46×10^-07
Asns Asns^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	1.61×10^-07
Mtmr12 Mtmr12^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	2.57×10^-07
Rgl1 Rgl1^em1(IMPC)Mbp	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	2.94×10^-07
2810408A11Rik 2810408A11Rik^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	3.77×10^-07
Dcbld2 Dcbld2^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	5.73×10^-07
Gpld1 Gpld1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	7.34×10^-07
Gimap6 Gimap6^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	8.00×10^-07
Acsl5 Acsl5^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	9.13×10^-07
Dbnl Dbnl^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	1.83×10^-06
Mpdz Mpdz^em1(IMPC)J	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	2.59×10^-06
Gpr101 Gpr101^{tm1b(KOMP)Mbp}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	2.67×10^-06
Lama4 Lama4^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	2.79×10^-06
Epb41l5 Epb41l5^{tm1a(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	3.14×10^-06
Rpa1 Rpa1^{tm1b(KOMP)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	3.56×10^-06
Col1a2 Col1a2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	BCM \| IMPC	3.81×10^-06
Rimklb Rimklb^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	3.90×10^-06
Rnf10 Rnf10^{tm1b(KOMP)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	TCP \| IMPC	4.06×10^-06
Ptpn5 Ptpn5^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	4.53×10^-06
Ttc28 Ttc28^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	TCP \| IMPC	6.12×10^-06
Pabpc4 Pabpc4^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	6.97×10^-06
Hcn1 Hcn1^em1(IMPC)H	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	7.48×10^-06
Bod1 Bod1^{tm1b(KOMP)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	MARC \| IMPC	7.93×10^-06
Pebp1 Pebp1^em1(IMPC)Tcp	HOM	Late adult	increased heart weight	Heart Weight \| Heart weight	TCP \| IMPC	9.71×10^-06
Nalcn Nalcn^em1(IMPC)Mbp	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	1.01×10^-05
Pacsin2 Pacsin2^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	1.11×10^-05
Elmod1 Elmod1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	1.28×10^-05
Stx8 Stx8^{tm2a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	1.35×10^-05
Ap4e1 Ap4e1^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	KMPC \| IMPC	1.54×10^-05
Rnf115 Rnf115^em1(IMPC)H	HOM	Late adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	1.64×10^-05
Ide Ide^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart Dissection \| Heart weight	WTSI \| EuroPhenome	1.79×10^-05
Fbxo43 Fbxo43^{em1(IMPC)Marc}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	MARC \| IMPC	1.81×10^-05
Bbox1 Bbox1^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	2.28×10^-05
Setd2 Setd2^{tm1b(NCOM)Mfgc}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	TCP \| IMPC	2.37×10^-05
Gabarapl2 Gabarapl2^{tm1b(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	2.42×10^-05
Tnfaip1 Tnfaip1^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	2.46×10^-05
Tmem255b Tmem255b^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	2.56×10^-05
Gsto2 Gsto2^{tm2a(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	2.98×10^-05
Sparc Sparc^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	WTSI \| EuroPhenome	3.30×10^-05
Gimap8 Gimap8^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	3.36×10^-05
Timm50 Timm50^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	3.65×10^-05
Dppa1 Dppa1^{tm1a(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	WTSI \| IMPC	4.30×10^-05
Elk4 Elk4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	HMGU \| EuroPhenome	4.49×10^-05
Ttll10 Ttll10^em1(IMPC)J	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	4.57×10^-05
Pink1 Pink1^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	5.10×10^-05
H2-M5 H2-M5^{tm1(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Dissection \| Heart weight	WTSI \| MGP	5.30×10^-05
Rcc2 Rcc2^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	5.87×10^-05
Hspb1 Hspb1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	5.99×10^-05
Xylb Xylb^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	MRC Harwell \| EuroPhenome	6.26×10^-05
Ino80 Ino80^{tm1a(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	6.40×10^-05
4932438A13Rik 4932438A13Rik^{tm1b(EUCOMM)Hmgu}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	JAX \| IMPC	7.76×10^-05
Tbc1d20 Tbc1d20^em1(IMPC)Mbp	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	7.82×10^-05
Ap4e1 Ap4e1^em2(IMPC)Mbp	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	UC Davis \| IMPC	7.94×10^-05
Shank3 Shank3^em1(IMPC)H	HOM	Late adult	increased heart weight	Organ Weight \| Heart weight	MRC Harwell \| IMPC	8.01×10^-05
Dcp2 Dcp2^{tm1b(KOMP)Wtsi}	HET	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	8.29×10^-05
Phex Phex^{not yet available}	HOM	Early adult	increased heart weight	Heart weight/tibia length \| Heart weight	HMGU \| EuroPhenome	9.56×10^-05
Prkab1 Prkab1^{tm1b(KOMP)Wtsi}	HOM	Early adult	increased heart weight	Heart Weight \| Heart weight	ICS \| IMPC	9.74×10^-05

Download data as: TSV XLS

The way we measure

Procedure
Heart Dissection
Heart Weight
Heart weight/tibia length
Organ Weight

Phenotype associations stats

1.57% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (77/4903)

1.07% females (52/4844) 1.40% males (68/4873)

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Phenotype: increased heart weight

IMPC Gene variants with increased heart weight

The way we measure

Phenotype associations stats

The IMPC Newsletter

Access Data Release 10.1 Data