Phenotype: increased heart weight

Definition
greater than average weight of the heart compared to controls
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 138

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 0.00
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.78×10-27
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 3.00×10-13
Gnas
Gnastm1Jop
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 7.03×10-12
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 4.48×10-11
Taco1
Taco1em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.81×10-10
Tmem203
Tmem203em1(IMPC)H
HOM   Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.94×10-10
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.99×10-09
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.83×10-09
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.99×10-09
Trappc2l
Trappc2lem1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 5.70×10-09
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 5.81×10-09
Kcng2
Kcng2em1(IMPC)Bay
HOM Early adult increased heart weight Heart Weight | Heart weight BCM | IMPC 7.07×10-09
Dbnl
Dbnltm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 8.00×10-09
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 1.01×10-08
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.92×10-08
Pdp1
Pdp1em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.31×10-08
Stx11
Stx11em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.41×10-08
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.73×10-08
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 8.13×10-08
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.19×10-07
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.54×10-07
Lrrc41
Lrrc41em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.66×10-07
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart Weight | Heart weight BCM | IMPC 2.25×10-07
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.72×10-07
Ppp2r5c
Ppp2r5cem1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.73×10-07
Rap1gap2
Rap1gap2tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 3.12×10-07
Ywhaz
Ywhaztm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 4.40×10-07
Steap3
Steap3tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 4.65×10-07
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 5.35×10-07
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight MARC | IMPC 5.38×10-07
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 5.49×10-07
Mpv17
Mpv17em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 5.99×10-07
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 6.36×10-07
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.88×10-07
Nos3
Nos3em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 8.79×10-07
2610507B11Rik
2610507B11Rikem1(IMPC)J
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.12×10-06
Hcn1
Hcn1em1(IMPC)H
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.38×10-06
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.60×10-06
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.75×10-06
Xpo1
Xpo1em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.79×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 2.84×10-06
Rhbdf2
Rhbdf2Rhbdf2
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 3.25×10-06
Stox2
Stox2tm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 3.41×10-06
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.21×10-06
Adgrf5
Adgrf5tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 4.38×10-06
Vsig4
Vsig4tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 4.50×10-06
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.69×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 5.42×10-06
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Early adult increased heart weight Heart Weight | Heart weight MARC | IMPC 5.43×10-06
Nptn
Nptntm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.47×10-06
Taco1
Taco1em1(IMPC)J
HOM   Late adult increased heart weight Heart Weight | Heart weight JAX | IMPC 5.84×10-06
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 6.00×10-06
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.10×10-06
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 7.10×10-06
Gda
Gdatm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 7.39×10-06
Tbl1xr1
Tbl1xr1tm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight HMGU | IMPC 7.39×10-06
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 8.03×10-06
Cidec
Cidectm1(EGFP_CreERT2)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 8.09×10-06
Rasa1
Rasa1tm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 8.43×10-06
Gorasp1
Gorasp1tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 8.56×10-06
Mir129-2
Mir129-2em1(IMPC)KMPC
HOM Late adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 1.01×10-05
Atp5b
Atp5btm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 1.03×10-05
Erap1
Erap1tm2b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 1.25×10-05
Hivep1
Hivep1tm1(KOMP)Mbp
HET   Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.26×10-05
Acvr1c
Acvr1ctm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.31×10-05
Rhpn1
Rhpn1tm1b(KOMP)Wtsi
HOM   Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.40×10-05
Pex3
Pex3tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | MGP 1.45×10-05
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 1.61×10-05
Fstl1
Fstl1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.74×10-05
Gimap8
Gimap8tm1.1(KOMP)Vlcg
HOM   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.81×10-05
Mpdz
Mpdzem1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.02×10-05
Plaat3
Plaat3em1(IMPC)Tcp
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 2.04×10-05
Atg2b
Atg2bem1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.14×10-05
Kpna4
Kpna4em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.18×10-05
Slit2
Slit2em1(IMPC)Mbp
HET   Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.33×10-05
Hddc2
Hddc2em1(IMPC)H
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.44×10-05
Ptgis
Ptgisem1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.44×10-05
Pebp1
Pebp1em1(IMPC)Tcp
HOM   Late adult increased heart weight Heart Weight | Heart weight TCP | IMPC 2.53×10-05
Mplkip
Mplkiptm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.68×10-05
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.84×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 2.93×10-05
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.93×10-05
H2-M5
H2-M5tm1(KOMP)Wtsi
HOM   Early adult increased heart weight Heart Dissection | Heart weight WTSI | MGP 3.40×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM   Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 3.44×10-05
Nox4
Nox4tm1.1Hwsc
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 3.46×10-05
Fastk
Fastktm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 3.54×10-05
Nog
Nogem1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 3.94×10-05
Cln6
Cln6tm1b(EUCOMM)Hmgu
HOM   Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 3.96×10-05
Dap
Daptm1a(KOMP)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 3.97×10-05
Cops7a
Cops7atm1b(KOMP)Mbp
HOM   Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.27×10-05
Btg1
Btg1em1(IMPC)Mbp
HOM   Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.37×10-05
Bbox1
Bbox1tm1b(KOMP)Wtsi
HOM   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 4.38×10-05
Plpp3
Plpp3tm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.44×10-05
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 4.48×10-05
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 4.48×10-05
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.54×10-05
Cdk12
Cdk12em1(IMPC)Tcp
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 4.61×10-05
Shisa6
Shisa6em1(IMPC)Tcp
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 4.74×10-05
Qsox1
Qsox1em1(IMPC)KMPC
HOM Late adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 5.16×10-05
4932438A13Rik
4932438A13Riktm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 5.17×10-05
Mturn
Mturntm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 5.30×10-05
Crabp2
Crabp2em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 5.53×10-05
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM   Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.63×10-05
Lox
Loxem1(IMPC)Mbp
HET Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 5.71×10-05
Arhgef6
Arhgef6tm2e.1(EUCOMM)Wtsi
HOM   Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 5.92×10-05
Dlg2
Dlg2tm1Dsb
HOM   Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 5.94×10-05
Lmna
Lmnatm1b(EUCOMM)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 5.95×10-05
Spns1
Spns1tm1e(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight/tibia length | Heart weight ICS | EuroPhenome 6.65×10-05
Kansl1
Kansl1tm1b(EUCOMM)Hmgu
HET   Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 6.78×10-05
Cacna1c
Cacna1cem1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 6.79×10-05
Zfp787
Zfp787em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 6.93×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 7.73×10-05
Ankrd12
Ankrd12tm1a(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 8.32×10-05
Erp44
Erp44tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.38×10-05
Ush1c
Ush1ctm1a(KOMP)Wtsi
HOM   Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.49×10-05
Tnks
Tnksem1(IMPC)Hmgu
HOM   Early adult increased heart weight Heart Weight | Heart weight HMGU | IMPC 8.65×10-05
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.81×10-05
Col27a1
Col27a1em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 9.21×10-05
Ptpn5
Ptpn5tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 9.30×10-05
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 9.53×10-05
Synj2
Synj2tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 9.53×10-05
Polb
Polbtm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 9.66×10-05
Etaa1
Etaa1em1(IMPC)Marc
HOM   Early adult increased heart weight Heart Weight | Heart weight MARC | IMPC 9.71×10-05
Slitrk2
Slitrk2em1(IMPC)Mbp
HEM   Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 9.71×10-05
Safb2
Safb2em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 9.77×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM   Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 9.80×10-05
Tbc1d20
Tbc1d20em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 9.83×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

2.11% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (127/6019)

0.37% females (21/5709) 1.51% males (86/5709)

Select a parameter    



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