Phenotype: increased heart weight

Definition
greater than average weight of the heart compared to controls
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 172

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.78×10-27
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 3.00×10-13
Gnas
Gnastm1Jop
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 7.03×10-12
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 4.48×10-11
Ptgis
Ptgisem1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.29×10-10
Taco1
Taco1em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.77×10-10
Slitrk2
Slitrk2em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.44×10-10
Trappc2l
Trappc2lem1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 5.14×10-10
Pdp1
Pdp1em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.50×10-09
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.00×10-09
Stx11
Stx11em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.51×10-09
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.80×10-09
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 4.49×10-09
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.92×10-08
Cndp2
Cndp2em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.38×10-08
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.73×10-08
Cidec
Cidectm1(EGFP_CreERT2)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 8.03×10-08
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 8.36×10-08
Ube2f
Ube2fem1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.02×10-07
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.19×10-07
Ppp2r5c
Ppp2r5cem1(IMPC)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 1.31×10-07
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.54×10-07
Lrrc41
Lrrc41em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.79×10-07
Asns
Asnstm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.91×10-07
Spz1
Spz1em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.93×10-07
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight BCM | IMPC 2.24×10-07
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.93×10-07
Rap1gap2
Rap1gap2tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 3.12×10-07
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight MARC | IMPC 5.44×10-07
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 5.65×10-07
Mpv17
Mpv17em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 5.86×10-07
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.88×10-07
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.02×10-06
2610507B11Rik
2610507B11Rikem1(IMPC)J
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.05×10-06
Clasp1
Clasp1em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.34×10-06
Ywhaz
Ywhaztm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 1.44×10-06
Hcn1
Hcn1em1(IMPC)H
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.47×10-06
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.60×10-06
Rhbdf2
Rhbdf2Rhbdf2
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 3.25×10-06
Kpna4
Kpna4em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 3.64×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 3.73×10-06
Erap1
Erap1tm2b(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 4.21×10-06
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.21×10-06
Gapvd1
Gapvd1em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 4.50×10-06
Stox2
Stox2tm2b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 4.75×10-06
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 5.42×10-06
Fbxo43
Fbxo43em1(IMPC)Marc
HOM Early adult increased heart weight Heart Weight | Heart weight MARC | IMPC 5.47×10-06
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 6.00×10-06
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.10×10-06
Gda
Gdatm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 7.39×10-06
Tbc1d20
Tbc1d20em1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 7.56×10-06
Gorasp1
Gorasp1tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 8.56×10-06
Nog
Nogem1(IMPC)Mbp
HET Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 9.68×10-06
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.13×10-05
Rab11fip3
Rab11fip3em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.15×10-05
Dbnl
Dbnltm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 1.20×10-05
Aldh2
Aldh2tm1a(EUCOMM)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 1.35×10-05
Nos3
Nos3em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 1.43×10-05
Acvr1c
Acvr1ctm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 1.66×10-05
Mpdz
Mpdzem1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 2.17×10-05
Ttc28
Ttc28tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 2.42×10-05
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 2.54×10-05
Hddc2
Hddc2em1(IMPC)H
HOM Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.59×10-05
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 2.68×10-05
Mplkip
Mplkiptm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 2.72×10-05
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.84×10-05
Atp5b
Atp5btm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 2.86×10-05
Nox4
Nox4tm1.1Hwsc
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 3.46×10-05
Crabp2
Crabp2em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 3.47×10-05
Hs3st3a1
Hs3st3a1tm1(KOMP)Vlcg
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 3.58×10-05
Dcaf10
Dcaf10tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 3.65×10-05
Ap4e1
Ap4e1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | MGP 3.65×10-05
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 3.96×10-05
Dap
Daptm1a(KOMP)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 3.97×10-05
Plpp3
Plpp3tm1b(EUCOMM)Hmgu
HET Early adult increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.34×10-05
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 4.48×10-05
Serf1
Serf1tm1a(EUCOMM)Hmgu
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 4.54×10-05
Col27a1
Col27a1em1(IMPC)Mbp
HET Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 4.82×10-05
Arhgef4
Arhgef4tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 5.02×10-05
H2-M5
H2-M5tm1(KOMP)Wtsi
HOM Early adult increased heart weight Heart Dissection | Heart weight WTSI | MGP 5.43×10-05
Mturn
Mturntm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart Weight | Heart weight UC Davis | IMPC 5.52×10-05
Lmna
Lmnatm1b(EUCOMM)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight ICS | IMPC 5.95×10-05
Pate4
Pate4tm1.1(KOMP)Mbp
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 6.37×10-05
Mir129-2
Mir129-2em1(IMPC)KMPC
HOM Late adult increased heart weight Heart Weight | Heart weight KMPC | IMPC 6.42×10-05
Spns1
Spns1tm1e(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight/tibia length | Heart weight ICS | EuroPhenome 6.65×10-05
Zfp787
Zfp787em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 6.89×10-05
Nrsn1
Nrsn1tm1.1(KOMP)Vlcg
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 7.04×10-05
Plaat3
Plaat3em1(IMPC)Tcp
HOM Early adult increased heart weight Heart Weight | Heart weight TCP | IMPC 7.52×10-05
Mysm1
Mysm1tm1a(KOMP)Wtsi
HOM Early adult increased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 7.73×10-05
Tmc7
Tmc7em1(IMPC)Mbp
HOM Early adult increased heart weight Organ Weight | Heart weight UC Davis | IMPC 8.08×10-05
Ankrd12
Ankrd12tm1a(EUCOMM)Wtsi
HET Early adult increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 8.32×10-05
Erp44
Erp44tm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.38×10-05
Zfp84
Zfp84tm1b(KOMP)Wtsi
HOM Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.81×10-05
Safb2
Safb2em1(IMPC)J
HOM Early adult increased heart weight Heart Weight | Heart weight JAX | IMPC 9.51×10-05
Polb
Polbtm1a(KOMP)Wtsi
HET Early adult increased heart weight Heart Weight | Heart weight WTSI | IMPC 9.66×10-05

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 The way we measure

 Phenotype associations stats

1.62% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (94/5803)

0.06% females (3/5430) 1.64% males (89/5427)

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