Phenotype: increased heart weight

Definition
greater than average weight of the heart compared to controls
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with increased heart weight

Total number of significant genotype-phenotype associations: 109

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 0.00
Mybpc3
Mybpc3tm1a(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.17×10-19
Slc25a4
Slc25a4tm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 1.89×10-19
Gnas
Gnastm1Jop
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.14×10-11
Sik1
Sik1tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 3.64×10-11
Ric1
Ric1tm1a(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.73×10-11
Ttc39a
Ttc39atm1b(KOMP)Mbp
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 1.91×10-10
Ndufs3
Ndufs3tm1a(EUCOMM)Wtsi
HET postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 2.25×10-09
Rab19
Rab19tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 3.41×10-09
Ash1l
Ash1ltm2b(EUCOMM)Hmgu
HET postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 3.99×10-09
Tbl1xr1
Tbl1xr1tm1b(EUCOMM)Hmgu
HET postnatal increased heart weight Heart Weight | Heart weight HMGU | IMPC 5.29×10-09
Grm6
Grm6tm1b(EUCOMM)Wtsi
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.90×10-08
Lcn2
Lcn2tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 2.64×10-08
Rap1gap2
Rap1gap2tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 3.62×10-08
Cidec
Cidectm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 5.10×10-08
Srcin1
Srcin1tm1.1(KOMP)Vlcg
HET postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 6.07×10-08
Dbn1
Dbn1tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 7.23×10-08
Itch
Itchtm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 7.75×10-08
Dynlrb2
Dynlrb2tm1a(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.06×10-08
Exd1
Exd1tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 9.62×10-08
Asns
Asnstm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.61×10-07
Tead1
Tead1tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 3.22×10-07
2810408A11Rik
2810408A11Riktm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 3.77×10-07
Mtmr12
Mtmr12tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 6.70×10-07
Dcbld2
Dcbld2tm1a(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 6.99×10-07
Gpld1
Gpld1tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 7.34×10-07
Gimap6
Gimap6tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 8.01×10-07
Smurf2
Smurf2tm1b(EUCOMM)Wtsi
HET postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 8.59×10-07
Acsl5
Acsl5tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 9.13×10-07
Nos1ap
Nos1aptm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 1.04×10-06
Mpdz
Mpdzem1(IMPC)J
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 2.11×10-06
Gpr101
Gpr101tm1b(KOMP)Mbp
HOM postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 2.67×10-06
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 2.79×10-06
Epb41l5
Epb41l5tm1a(EUCOMM)Hmgu
HET postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 3.14×10-06
Rimklb
Rimklbtm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 3.35×10-06
Rnf10
Rnf10tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight TCP | IMPC 4.06×10-06
Rpa1
Rpa1tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.13×10-06
Lrrc15
Lrrc15tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.22×10-06
Bcl7a
Bcl7atm1b(EUCOMM)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 5.63×10-06
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 5.87×10-06
Ap4e1
Ap4e1tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight KMPC | IMPC 6.64×10-06
Bod1
Bod1tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 7.93×10-06
Hcn1
Hcn1em1(IMPC)H
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 8.11×10-06
Pabpc4
Pabpc4tm1a(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 8.27×10-06
Lep
Leptm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 8.62×10-06
Rab36
Rab36tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 8.82×10-06
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 9.89×10-06
Ptpn5
Ptpn5tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 1.01×10-05
Elmod1
Elmod1tm1b(EUCOMM)Hmgu
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 1.28×10-05
Stx8
Stx8tm2a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 1.35×10-05
Fbxo43
Fbxo43em1(IMPC)Marc
HOM postnatal increased heart weight Heart Weight | Heart weight MARC | IMPC 1.81×10-05
Tnfaip1
Tnfaip1tm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.46×10-05
Tmem255b
Tmem255btm1a(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 2.56×10-05
Gabarapl2
Gabarapl2tm1b(EUCOMM)Hmgu
HET postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 2.77×10-05
Gsto2
Gsto2tm2a(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 2.92×10-05
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight BCM | IMPC 3.09×10-05
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight WTSI | EuroPhenome 3.30×10-05
Timm50
Timm50tm1b(EUCOMM)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 3.65×10-05
Bbox1
Bbox1tm1b(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 4.33×10-05
Dppa1
Dppa1tm1a(KOMP)Wtsi
HOM postnatal increased heart weight Heart Weight | Heart weight WTSI | IMPC 4.39×10-05
Lrig1
Lrig1tm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart Dissection | Heart weight WTSI | MGP 4.42×10-05
Elk4
Elk4tm1a(EUCOMM)Wtsi
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 4.49×10-05
Pink1
Pink1tm1b(EUCOMM)Wtsi
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 4.72×10-05
Ttll10
Ttll10em1(IMPC)J
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.32×10-05
Gimap8
Gimap8tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 5.34×10-05
Zc3hc1
Zc3hc1tm1a(KOMP)Wtsi
HET postnatal increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 5.44×10-05
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM postnatal increased heart weight Organ Weight | Heart weight MRC Harwell | IMPC 5.63×10-05
Xylb
Xylbtm1a(EUCOMM)Hmgu
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight MRC Harwell | EuroPhenome 6.26×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 6.40×10-05
Hspb1
Hspb1tm1.1(KOMP)Vlcg
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 7.65×10-05
Ccdc57
Ccdc57tm1a(EUCOMM)Wtsi
HET postnatal increased heart weight Heart Dissection | Heart weight WTSI | EuroPhenome 7.82×10-05
Dcp2
Dcp2tm1b(KOMP)Wtsi
HET postnatal increased heart weight Heart Weight | Heart weight ICS | IMPC 8.29×10-05
Nalcn
Nalcnem1(IMPC)Mbp
HET postnatal increased heart weight Heart Weight | Heart weight UC Davis | IMPC 8.35×10-05
Phex
Phexnot yet available
HOM postnatal increased heart weight Heart weight/tibia length | Heart weight HMGU | EuroPhenome 9.56×10-05
Clstn2
Clstn2em1(IMPC)J
HOM postnatal increased heart weight Heart Weight | Heart weight JAX | IMPC 9.82×10-05

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 The way we measure

 Phenotype associations stats

1.63% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased heart weight (75/4610)

1.03% females (47/4544) 1.36% males (62/4575)

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