Phenotype: dilated heart left ventricle

Definition
the luminal space of the lower left chamber of the heart is increased in volume or area, usually with an increase in contained fluid
Synonyms
left ventricular dilation,  dilated left ventricle,  left ventricle dilation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with dilated heart left ventricle

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MRC Harwell
IMPC
0.00
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
4.37×10-12
Ints6l
Ints6lem1(IMPC)Marc
HEM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
7.82×10-10
Mapkap1
Mapkap1tm1b(EUCOMM)Wtsi
HET Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
3.15×10-07
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
9.66×10-07
Dsg2
Dsg2tm1b(EUCOMM)Wtsi
HOM   Early adult dilated heart left ventricle LVIDs
Echo
BCM
IMPC
1.20×10-06
Arhgap40
Arhgap40tm1b(KOMP)Wtsi
HOM Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
2.19×10-06
Grem2
Grem2em1(IMPC)Bay
HET   Early adult dilated heart left ventricle End-Diastolic Diameter
Echo
BCM
IMPC
4.21×10-06
Ap1ar
Ap1artm2b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle LVIDd
Echo
BCM
IMPC
7.99×10-06
Tmem169
Tmem169em1(IMPC)Mhzh
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
8.63×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
9.95×10-06
Fam126a
Fam126aem1(IMPC)Ccpcz
HOM   Early adult dilated heart left ventricle LVIDd
Echo
CCP-IMG
IMPC
1.34×10-05
Snx25
Snx25tm1b(KOMP)Wtsi
HET Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
1.98×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
2.27×10-05
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HOM   Early adult dilated heart left ventricle End-Systolic Diameter
Echo
BCM
IMPC
2.45×10-05
Churc1
Churc1tm1b(EUCOMM)Wtsi
HOM   Early adult dilated heart left ventricle LVIDs
Echo
CCP-IMG
IMPC
2.96×10-05
Card11
Card11em1(IMPC)Ccpcz
HOM   Early adult dilated heart left ventricle End-Systolic Diameter
Echo
CCP-IMG
IMPC
3.02×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi
HOM   Early adult dilated heart left ventricle LVIDs
Echo
MARC
IMPC
3.35×10-05
Pex1
Pex1tm1e.1(EUCOMM)Hmgu
HET Early adult dilated heart left ventricle LVIDs
Echo
HMGU
IMPC
4.19×10-05
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult dilated heart left ventricle LVIDd
Echo
HMGU
IMPC
4.33×10-05
Fmc1
Fmc1tm1b(EUCOMM)Wtsi
HET   Early adult dilated heart left ventricle End-Systolic Diameter
Echo
BCM
IMPC
7.80×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.15% of tested genes with null mutations on a B6N genetic background have a phenotype association to dilated heart left ventricle (21/1826)

0.33% females (6/1800) 0.66% males (10/1521)

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