Phenotype: abnormal cranial nerve morphology

Definition
any structural anomaly of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves
Synonyms
cranial nerve dysplasia
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal cranial nerve morphology

Total number of significant genotype-phenotype associations: 91

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Angptl4
Angptl4tm1b(EUCOMM)Hmgu
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
MRC Harwell
IMPC
0.00
Atg9b
Atg9btm1b(KOMP)Mbp
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Bnip3
Bnip3em1(IMPC)Mbp
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Cacna1f
Cacna1ftm1.1(KOMP)Vlcg
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Ccdc25
Ccdc25em1(IMPC)Mbp
HET Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Crbn
Crbntm1b(KOMP)Wtsi
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Dsc3
Dsc3tm1b(EUCOMM)Wtsi
HET Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
MRC Harwell
IMPC
0.00
Gpx7
Gpx7tm1.1(KOMP)Vlcg
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Krit1
Krit1tm1.1(KOMP)Vlcg
HET Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Npas2
Npas2em1(IMPC)Mbp
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Phldb2
Phldb2em1(IMPC)H
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
MRC Harwell
IMPC
0.00
Prepl
Preplem1(IMPC)H
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
MRC Harwell
IMPC
0.00
Timp4
Timp4em1(IMPC)Mbp
HOM Early adult absent optic nerve Eye with optic nerve
Gross Pathology and Tissue Collection
UC Davis
IMPC
0.00
Mdm1
Mdm1em1(IMPC)KMPC
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
KMPC
IMPC
1.65×10-16
Pitx2
Pitx2tm1b(EUCOMM)Wtsi
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
7.33×10-16
Pepd
Pepdtm1b(KOMP)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
1.17×10-15
Ppfibp2
Ppfibp2em1(IMPC)Tcp
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
3.66×10-15
Nbas
Nbastm1b(EUCOMM)Hmgu
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
6.68×10-15
Sh3rf1
Sh3rf1em1(IMPC)J
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
2.90×10-14
Dnmbp
Dnmbpem1(IMPC)Mbp
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
UC Davis
IMPC
4.03×10-14
Bmp4
Bmp4tm1b(EUCOMM)Hmgu
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
1.19×10-12
Col18a1
Col18a1tm1.1(KOMP)Vlcg
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
3.46×10-11
Stx5a
Stx5atm1b(EUCOMM)Hmgu
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
3.52×10-08
Mettl5
Mettl5em1(IMPC)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
6.36×10-08
Ehmt1
Ehmt1tm1b(EUCOMM)Hmgu
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MARC
IMPC
1.62×10-07
Ptp4a1
Ptp4a1em2(IMPC)Tcp
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
1.64×10-07
Trf
Trfem1(IMPC)J
HET Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
2.44×10-07
Stoml1
Stoml1em1(IMPC)Tcp
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
2.59×10-07
Agbl1
Agbl1em1(IMPC)J
HOM   Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
3.82×10-07
1700001O22Rik
1700001O22Rikem1(IMPC)J
HOM   Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
6.47×10-07
Hmcn1
Hmcn1em1(IMPC)J
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
9.52×10-07
Fbn2
Fbn2em1(IMPC)Rbrc
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
RBRC
IMPC
1.01×10-06
Fam160b1
Fam160b1em1(IMPC)J
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
1.42×10-06
Rnf168
Rnf168tm2b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
CCP-IMG
IMPC
1.44×10-06
Dbnl
Dbnltm1b(KOMP)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
ICS
IMPC
2.08×10-06
Nub1
Nub1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
CCP-IMG
IMPC
2.58×10-06
Cib3
Cib3em1(IMPC)H
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
3.28×10-06
Dpp3
Dpp3tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
3.55×10-06
Nxn
Nxntm1b(EUCOMM)Wtsi
HET   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MARC
IMPC
4.45×10-06
Spin1
Spin1tm1.1(KOMP)Vlcg
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
5.05×10-06
Trim39
Trim39tm1b(EUCOMM)Hmgu
HOM   Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
8.43×10-06
Ahsa1
Ahsa1em1(IMPC)J
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
1.07×10-05
Ik
Ikem2(IMPC)KMPC
HET   Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
KMPC
IMPC
1.15×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
1.21×10-05
Zbtb5
Zbtb5tm2b(EUCOMM)Hmgu
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
1.26×10-05
Plekhm1
Plekhm1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
1.32×10-05
Rxfp2
Rxfp2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
1.39×10-05
Nos1ap
Nos1aptm1b(KOMP)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
1.42×10-05
E2f3
E2f3tm1b(KOMP)Wtsi
HET   Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
KMPC
IMPC
1.51×10-05
Cidec
Cidectm1b(EUCOMM)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
1.67×10-05
Spidr
Spidrtm1b(EUCOMM)Hmgu
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
1.78×10-05
Obp2a
Obp2atm1b(EUCOMM)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
ICS
IMPC
1.83×10-05
Pex6
Pex6em1(IMPC)Tcp
HET   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
2.07×10-05
Mapkapk2
Mapkapk2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
2.60×10-05
Pard3
Pard3tm1b(KOMP)Wtsi
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
2.60×10-05
Egr1
Egr1tm1b(NCOM)Mfgc
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
2.61×10-05
Zfp329
Zfp329em1(IMPC)J
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
2.73×10-05
Hipk4
Hipk4tm1b(KOMP)Mbp
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
2.97×10-05
Shmt2
Shmt2em1(IMPC)Bay
HET   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
3.33×10-05
Ppfia2
Ppfia2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
3.76×10-05
Cant1
Cant1tm1b(EUCOMM)Hmgu
HET   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
3.76×10-05
Aif1
Aif1tm1.1(KOMP)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
HMGU
IMPC
3.84×10-05
Plekha5
Plekha5em1(IMPC)Tcp
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
3.89×10-05
Kdm8
Kdm8tm1b(EUCOMM)Wtsi
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
3.93×10-05
Zfp930
Zfp930tm1b(KOMP)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
BCM
IMPC
4.31×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
5.62×10-05
Tmem11
Tmem11em1(IMPC)Tcp
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
6.53×10-05
Apmap
Apmapem1(IMPC)J
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
6.88×10-05
Zzef1
Zzef1tm2.1(KOMP)Vlcg
HOM   Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
7.50×10-05
Prdm5
Prdm5em1(IMPC)Tcp
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
8.19×10-05
Sra1
Sra1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
TCP
IMPC
8.19×10-05
Tex2
Tex2tm1.1(KOMP)Vlcg
HOM Late adult abnormal optic disk morphology Optic Disc
Eye Morphology
JAX
IMPC
8.73×10-05
Dnm1l
Dnm1ltm1b(KOMP)Wtsi
HET Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
ICS
IMPC
8.84×10-05
Slc7a11
Slc7a11tm1b(EUCOMM)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
ICS
IMPC
8.84×10-05
Rcc2
Rcc2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
9.41×10-05
Gbx1
Gbx1tm1b(KOMP)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
9.63×10-05
Col1a2
Col1a2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal optic disk morphology Optic Disc
Eye Morphology
MRC Harwell
IMPC
9.90×10-05

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 The way we measure

 Phenotype associations stats

105.48% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal cranial nerve morphology (77/73)

53.42% females (39/73) 44.62% males (29/65)

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