Phenotype: abnormal snout morphology

Definition
any structural anomaly of the anterior facial part of the face or muzzle containing the oral and nasal regions
Synonyms
abnormal nose shape,  snout abnormalities,  abnormal snout,  snout dysplasia,  abnormal snout shape,  snout shape abnormalities,  abnormal muzzle morphology
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal snout morphology

Total number of significant genotype-phenotype associations: 36

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Erf
Erftm1.1(KOMP)Mbp
HET postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size UC Davis | IMPC 7.47×10-16
Duoxa2
Duoxa2tm1b(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size WTSI | IMPC 2.01×10-11
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | EuroPhenome 6.07×10-11
Daam2
Daam2tm1b(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 5.02×10-10
Celsr1
Celsr1Scy
HET postnatal abnormal snout morphology Dysmorphology | muzzle/snout length MRC Harwell | EuroPhenome 6.48×10-10
Daam2
Daam2tm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 7.06×10-10
Smoc1
Smoc1tm1b(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 1.28×10-09
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | EuroPhenome 7.96×10-09
Cyb561
Cyb561tm1b(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 4.42×10-08
Mef2b
Mef2btm2b(EUCOMM)Hmgu
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 1.05×10-07
F7
F7tm1b(EUCOMM)Hmgu
HET postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 2.90×10-07
Vangl2
Vangl2Lp
HET postnatal abnormal snout morphology Dysmorphology | muzzle/snout length MRC Harwell | EuroPhenome 5.08×10-07
Hbs1l
Hbs1ltm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size WTSI | IMPC 5.86×10-07
Zc3hc1
Zc3hc1tm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | MGP 6.69×10-07
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 1.34×10-06
Exoc3l2
Exoc3l2tm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 6.65×10-06
Nxn
Nxntm1b(EUCOMM)Wtsi
HET postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 6.65×10-06
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 1.91×10-05
Rhobtb3
Rhobtb3tm1a(KOMP)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | MGP 2.25×10-05
Hsp90aa1
Hsp90aa1tm1(KOMP)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 2.31×10-05
Sorl1
Sorl1tm1b(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 2.64×10-05
Rgl3
Rgl3em1(IMPC)H
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 3.94×10-05
Klhdc2
Klhdc2tm1b(EUCOMM)Hmgu
HET postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 4.04×10-05
Eps8l2
Eps8l2tm1b(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout size MRC Harwell | IMPC 5.30×10-05
Ide
Idetm1a(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | MGP 8.36×10-05
Nsun2
Nsun2tm1a(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Dysmorphology | Snout morphology WTSI | MGP 8.36×10-05
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM postnatal abnormal snout morphology Combined SHIRPA and Dysmorphology | Snout morphology WTSI | IMPC 9.32×10-05

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 The way we measure

 Phenotype associations stats

0.51% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal snout morphology (26/5056)

0.32% females (16/5025) 0.38% males (19/5034)

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