Phenotype: abnormal heart looping

Definition
any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration
Synonyms
abnormal looping morphogenesis,  abnormal cardiac looping
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart looping

Total number of significant genotype-phenotype associations: 17

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Hyls1
Hyls1em1(IMPC)Tcp
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping TCP | IMPC 0.00
Ift43
Ift43tm1b(EUCOMM)Hmgu
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Krit1
Krit1tm1.1(KOMP)Vlcg
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Nr6a1
Nr6a1tm1b(EUCOMM)Wtsi
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Pcgf1
Pcgf1tm1.1(KOMP)Vlcg
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Pibf1
Pibf1tm1.1(KOMP)Vlcg
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.00
Pigq
Pigqtm2b(EUCOMM)Wtsi
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.00
Slc25a3
Slc25a3tm1b(EUCOMM)Wtsi
HET embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.00
Tedc1
Tedc1em1(IMPC)Tcp
HOM embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping TCP | IMPC 0.00

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 The way we measure

 Phenotype associations stats

2.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart looping (9/451)

2.02% females (9/445) 1.87% males (8/427)

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