Phenotype: abnormal heart looping

Definition
any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration
Synonyms
abnormal cardiac looping
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart looping

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Flnc
Flncem1(IMPC)Bay
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
BCM
IMPC
0.00
Hyls1
Hyls1em1(IMPC)Tcp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
TCP
IMPC
0.00
Ift43
Ift43tm1b(EUCOMM)Hmgu
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
BCM
IMPC
0.00
Ift52
Ift52em1(IMPC)Bay
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
BCM
IMPC
0.00
Krit1
Krit1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Nr6a1
Nr6a1tm1b(EUCOMM)Wtsi
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
BCM
IMPC
0.00
Pcgf1
Pcgf1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
JAX
IMPC
0.00
Pcnp
Pcnpem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Pibf1
Pibf1tm1.1(KOMP)Vlcg
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
JAX
IMPC
0.00
Pigq
Pigqtm2b(EUCOMM)Wtsi
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
BCM
IMPC
0.00
Pkdcc
Pkdccem1(IMPC)Mbp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Pole2
Pole2em1(IMPC)Mbp
HET E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Rgl1
Rgl1em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Tbx20
Tbx20em1(IMPC)Mbp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00
Tedc1
Tedc1em1(IMPC)Tcp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
TCP
IMPC
0.00
Vcan
Vcanem2(IMPC)Mbp
HOM E9.5 abnormal heart looping Heart looping
Gross Morphology Embryo E9.5
UC Davis
IMPC
0.00

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 The way we measure

 Phenotype associations stats

2.00% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart looping (16/802)

2.74% females (15/547) 2.43% males (13/534)

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