Phenotype: abnormal heart looping

Definition any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration

Synonyms
  • abnormal looping morphogenesis
  • abnormal looping morphogenesis
  • abnormal cardiac looping
  • abnormal cardiac looping
Related
Synonyms
  • delayed cardiac looping
  • delayed cardiac looping
  • delayed heart looping
  • delayed heart looping

MP browserMP:0000269

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Phenotype associations stats

1.79% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart looping (5/279)

1.83% females (5/273) 1.90% males (5/263)

Gene variants with abnormal heart looping

Total number of significant genotype-phenotype associations: 10

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value Data
Krit1
Krit1tm1.1(KOMP)Vlcg
HOM Female Male embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.0
Nr6a1
Nr6a1tm1b(EUCOMM)Wtsi
HOM Female Male embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping BCM | IMPC 0.0
Pcgf1
Pcgf1tm1.1(KOMP)Vlcg
HOM Female Male embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.0
Pibf1
Pibf1tm1.1(KOMP)Vlcg
HOM Female Male embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping JAX | IMPC 0.0
Slc25a3
Slc25a3tm1b(EUCOMM)Wtsi
HET Female Male embryonic day 9.5 abnormal heart looping Gross Morphology Embryo E9.5 | Heart looping UC Davis | IMPC 0.0

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