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Phenotype: decreased neutrophil cell number

Definition
reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes
Synonyms
decreased neutrophil count,  reduced neutrophil count,  reduced neutrophil cell number,  decreased neutrophil number,  neutropenia
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with decreased neutrophil cell number

Total number of significant genotype-phenotype associations: 47

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Tmem127
Tmem127tm1(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil percentage
Whole blood peripheral blood leukocyte immunophenotyping		 WTSI
3i		 0.00
Synj1
Synj1tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.19×10-15
Pkn1
Pkn1tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.21×10-13
Atl2
Atl2tm2b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.42×10-10
Csf3
Csf3em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.43×10-10
Gfi1b
Gfi1btm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 9.65×10-10
Cxcl9
Cxcl9tm1b(EUCOMM)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.45×10-08
Ccr2
Ccr2em1(IMPC)H 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 MRC Harwell
IMPC		 3.23×10-08
Avp
Avptm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.39×10-07
Itgae
Itgaetm1b(EUCOMM)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.98×10-07
Lypd2
Lypd2em1(IMPC)Marc 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MARC
IMPC		 2.05×10-07
Cib1
Cib1tm1b(EUCOMM)Hmgu 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.55×10-07
Flnb
Flnbtm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 9.28×10-07
Acvr2a
Acvr2atm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 TCP
IMPC		 9.53×10-07
C1ql3
C1ql3em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.66×10-06
Bdkrb1
Bdkrb1em1(IMPC)H 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.70×10-06
Pfkfb2
Pfkfb2tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 2.49×10-06
Pon2
Pon2tm1b(EUCOMM)Hmgu 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.59×10-06
Hnrnph1
Hnrnph1tm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 8.04×10-06
Ecm1
Ecm1tm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.10×10-05
Gprin1
Gprin1em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.26×10-05
Cdc7
Cdc7tm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 1.32×10-05
Plac9
Plac9tm1b(EUCOMM)Hmgu 		HOM Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.64×10-05
Cps1
Cps1em1(IMPC)H 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 1.70×10-05
Glra2
Glra2tm1b(KOMP)Wtsi 		HEM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 1.73×10-05
Bdp1
Bdp1em1(IMPC)Tcp 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 2.14×10-05
Aspscr1
Aspscr1em1(IMPC)Tcp 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 TCP
IMPC		 2.22×10-05
Tnfrsf1a
Tnfrsf1atm2b(EUCOMM)Wtsi 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.30×10-05
Ube2b
Ube2btm1b(EUCOMM)Wtsi 		HET   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 2.68×10-05
Fbxo10
Fbxo10tm1b(KOMP)Wtsi 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 2.89×10-05
Fstl1
Fstl1tm1b(EUCOMM)Hmgu 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 3.16×10-05
Spata24
Spata24tm1b(EUCOMM)Wtsi 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 MRC Harwell
IMPC		 4.03×10-05
Usp45
Usp45em1(IMPC)H 		HOM Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 4.75×10-05
Usp32
Usp32em1(IMPC)Mhzh 		HET   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 4.81×10-05
Rexo2
Rexo2tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 5.15×10-05
Ampd1
Ampd1tm1b(KOMP)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 TCP
IMPC		 5.19×10-05
Sdhb
Sdhbtm1b(EUCOMM)Hmgu 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 HMGU
IMPC		 5.21×10-05
Neurl4
Neurl4em1(IMPC)Mbp 		HOM   Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 UC Davis
IMPC		 5.23×10-05
Susd6
Susd6tm1b(KOMP)Wtsi 		HOM Late adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MRC Harwell
IMPC		 6.30×10-05
Ulk3
Ulk3em2(IMPC)Tcp 		HOM Late adult decreased neutrophil cell number Monocyte cell count
Hematology		 TCP
IMPC		 6.82×10-05
Rabggta
Rabggtatm1.1(KOMP)Vlcg 		HET Early adult decreased neutrophil cell number Neutrophil differential count
Hematology		 MARC
IMPC		 6.86×10-05
Dicer1
Dicer1tm1b(EUCOMM)Wtsi 		HET Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 MRC Harwell
IMPC		 6.98×10-05
Msi2
Msi2em1(IMPC)Mbp 		HOM   Early adult decreased neutrophil cell number Neutrophil cell count
Hematology		 UC Davis
IMPC		 8.78×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Hematology
Whole blood peripheral blood leukocyte immunophenotyping

 Phenotype associations stats

1.16% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased neutrophil cell number (43/3712)

0.26% females (9/3442) 0.99% males (34/3418)

Select a parameter    



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