MP:0000186 (decreased circulating HDL cholesterol level) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: decreased circulating HDL cholesterol level

Definition

reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion

Synonyms

low circulating HDL cholesterol level, reduced circulating HDL level

Significant gene associations The way we measure Phenotype stats

of tested genes

significant genes

tested genes

IMPC Gene variants with decreased circulating HDL cholesterol level

Total number of significant genotype-phenotype associations: 164

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Slc29a3 Slc29a3^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.22×10^-43
Atp13a3 Atp13a3^em1(IMPC)J	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	2.42×10^-33
Apoc4 Apoc4^{tm1.1(KOMP)Mbp}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	8.78×10^-24
Pcsk9 Pcsk9^{tm2b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	3.71×10^-21
Tnip1 Tnip1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	9.32×10^-20
Dennd5b Dennd5b^em1(IMPC)Tcp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	1.38×10^-19
Cpgi5563 Cpgi5563^{tm1.1(NCC)WCS}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.57×10^-15
Sec16b Sec16b^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.04×10^-14
Sox21 Sox21^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	2.87×10^-13
Tex261 Tex261^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.04×10^-13
Akap9 Akap9^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	2.52×10^-12
Zfand6 Zfand6^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	8.70×10^-12
Angptl3 Angptl3^{tm2b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	8.88×10^-12
Sik3 Sik3^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	9.34×10^-12
Ttc28 Ttc28^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	4.98×10^-11
Hr Hr^em1(IMPC)H	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	1.19×10^-10
Acsl5 Acsl5^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	4.72×10^-10
Dcun1d3 Dcun1d3^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.78×10^-10
Peak1 Peak1^em1(IMPC)J	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	5.81×10^-10
Sec24a Sec24a^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	1.08×10^-09
Nrxn1 Nrxn1^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	1.78×10^-09
Cenpo Cenpo^{tm1b(KOMP)Mbp}	HET	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	2.31×10^-09
Larp1 Larp1^em1(IMPC)Mbp	HET	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	5.63×10^-09
Dusp7 Dusp7^{tm1(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MARC IMPC	7.14×10^-09
Baat Baat^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	1.12×10^-08
Kics2 Kics2^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MARC IMPC	2.10×10^-08
Il2ra Il2ra^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	2.27×10^-08
Zfp84 Zfp84^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.19×10^-08
Setd1a Setd1a^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	3.22×10^-08
Nsf Nsf^{tm1b(KOMP)Mbp}	HET	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	4.01×10^-08
Sar1b Sar1b^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.32×10^-08
Etv6 Etv6^{em1(IMPC)Rbrc}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	RBRC IMPC	5.76×10^-08
Tial1 Tial1^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	9.18×10^-08
Arhgef4 Arhgef4^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	1.30×10^-07
Ywhab Ywhab^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.34×10^-07
Smc5 Smc5^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	1.67×10^-07
Dym Dym^em1(IMPC)Tcp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	1.85×10^-07
Far2 Far2^{tm2b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	2.16×10^-07
Elmod1 Elmod1^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	MRC Harwell EuroPhenome	2.63×10^-07
Nab2 Nab2^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	2.64×10^-07
Tmem203 Tmem203^em1(IMPC)H	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	2.64×10^-07
Bhlhe40 Bhlhe40^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	2.81×10^-07
Ahrr Ahrr^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	3.23×10^-07
Ctsa Ctsa^{tm2b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	3.54×10^-07
Myzap Myzap^em1(IMPC)J	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	3.95×10^-07
Atp8b1 Atp8b1^em1(IMPC)Tcp	HOM	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	4.01×10^-07
Spns2 Spns2^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	4.12×10^-07
Prkab1 Prkab1^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	4.38×10^-07
Gda Gda^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	4.41×10^-07
Sqstm1 Sqstm1^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.94×10^-07
4933434E20Rik 4933434E20Rik^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.29×10^-07
Baz1b Baz1b^{tm2a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	5.45×10^-07
Dbn1 Dbn1^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	7.29×10^-07
Fam117b Fam117b^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	MRC Harwell EuroPhenome	8.86×10^-07
Hspb6 Hspb6^em1(IMPC)J	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	9.70×10^-07
Mysm1 Mysm1^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	9.90×10^-07
Rbpj Rbpj^{tm1b(EUCOMM)Hmgu}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	9.99×10^-07
Gc Gc^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	1.00×10^-06
Vil1 Vil1^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.14×10^-06
Dnajc10 Dnajc10^{tm1a(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	MRC Harwell EuroPhenome	1.23×10^-06
Pcsk5 Pcsk5^{tm1b(KOMP)Mbp}	HET	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	1.34×10^-06
Csnk2a2 Csnk2a2^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	1.43×10^-06
Dnmt3a Dnmt3a^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	1.53×10^-06
Tmc6 Tmc6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	1.72×10^-06
Tnks Tnks^{em1(IMPC)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.73×10^-06
Camsap3 Camsap3^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	2.12×10^-06
Dync1i2 Dync1i2^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	2.81×10^-06
C1qtnf1 C1qtnf1^em1(IMPC)Mbp	HOM	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	2.90×10^-06
Trim8 Trim8^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.09×10^-06
Bcorl1 Bcorl1^em1(IMPC)Tcp	HEM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	3.29×10^-06
Sgo1 Sgo1^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	3.30×10^-06
Ptcd3 Ptcd3^{tm1.1(KOMP)Vlcg}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	4.17×10^-06
Dusp26 Dusp26^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.37×10^-06
Ndufs3 Ndufs3^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.51×10^-06
Trim56 Trim56^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	4.83×10^-06
Cbx6 Cbx6^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.10×10^-06
Slc38a2 Slc38a2^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.81×10^-06
Col18a1 Col18a1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	5.97×10^-06
Cracdl Cracdl^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	6.01×10^-06
Rhd Rhd^{tm1e(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	WTSI EuroPhenome	6.09×10^-06
Atad3a Atad3a^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	6.13×10^-06
Lactb Lactb^{tm1.1(KOMP)Mbp}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	6.76×10^-06
Krtap17-1 Krtap17-1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	9.92×10^-06
Csmd3 Csmd3^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	9.99×10^-06
Slc16a2 Slc16a2^{tm1a(KOMP)Wtsi}	HEM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	1.03×10^-05
Ngdn Ngdn^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.07×10^-05
Cdk12 Cdk12^em1(IMPC)Tcp	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	1.20×10^-05
Plekhf2 Plekhf2^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.22×10^-05
Dlg2 Dlg2^tm1Dsb	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	1.24×10^-05
Fbf1 Fbf1^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.40×10^-05
Rnf10 Rnf10^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	1.43×10^-05
Cenph Cenph^{tm1b(EUCOMM)Hmgu}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.46×10^-05
Enc1 Enc1^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.51×10^-05
Krt7 Krt7^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.57×10^-05
Dbnl Dbnl^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	1.61×10^-05
Prkd3 Prkd3^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	1.68×10^-05
Setd1b Setd1b^{tm1.2(IMPC)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.69×10^-05
Elk4 Elk4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	HMGU EuroPhenome	1.71×10^-05
Pnpt1 Pnpt1^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI EuroPhenome	1.72×10^-05
Kat2b Kat2b^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.73×10^-05
Cyfip1 Cyfip1^{tm2a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	1.74×10^-05
Tmod1 Tmod1^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	1.74×10^-05
Atp11a Atp11a^{tm1e(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.81×10^-05
Micos13 Micos13^{tm1.1(KOMP)Vlcg}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	1.94×10^-05
Wrap53 Wrap53^{tm1b(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	1.95×10^-05
Atad2b Atad2b^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	2.08×10^-05
Emcn Emcn^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	2.15×10^-05
Atg4b Atg4b^{tm1b(EUCOMM)Hmgu}	HOM	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	2.46×10^-05
Abcb4 Abcb4^em1(IMPC)H	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	2.50×10^-05
Pcdhb13 Pcdhb13^em1(IMPC)Tcp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	2.77×10^-05
Vangl2 Vangl2^Lp	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	MRC Harwell EuroPhenome	2.88×10^-05
Lmod3 Lmod3^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	3.22×10^-05
Morc2a Morc2a^{em1(IMPC)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.29×10^-05
Cyp27a1 Cyp27a1^{tm1.1(KOMP)Vlcg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	3.31×10^-05
Camsap3 Camsap3^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.40×10^-05
Susd6 Susd6^{tm1b(KOMP)Wtsi}	HOM	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	3.70×10^-05
Abhd14a Abhd14a^{tm2a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.79×10^-05
Pkn2 Pkn2^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	3.80×10^-05
Tmem42 Tmem42^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	3.89×10^-05
Becn1 Becn1^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	4.03×10^-05
Rab36 Rab36^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL cholesterol Plasma Chemistry	JAX IMPC	4.08×10^-05
Ube3b Ube3b^{Gt(RRJ142)Byg}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	4.52×10^-05
Rundc1 Rundc1^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	4.81×10^-05
Llgl2 Llgl2^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	4.94×10^-05
Sidt2 Sidt2^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.22×10^-05
Rhbdf2 Rhbdf2^Rhbdf2	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Fasted Clinical Chemistry	MRC Harwell EuroPhenome	5.31×10^-05
Tuft1 Tuft1^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	5.35×10^-05
Wdtc1 Wdtc1^{tm1a(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	6.48×10^-05
Dscc1 Dscc1^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	6.51×10^-05
Dusp16 Dusp16^em1(IMPC)Tcp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	TCP IMPC	6.76×10^-05
Zfp787 Zfp787^em1(IMPC)J	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	6.82×10^-05
Nucks1 Nucks1^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	6.92×10^-05
Cpgi15344 Cpgi15344^{tm1.1(NCC)WCS}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	7.16×10^-05
Palm Palm^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	7.18×10^-05
Tcf7l1 Tcf7l1^{tm1a(EUCOMM)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	7.30×10^-05
Pgam5 Pgam5^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	ICS IMPC	7.37×10^-05
Sag Sag^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	7.66×10^-05
C2cd4b C2cd4b^{em1(IMPC)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	7.86×10^-05
Zfp558 Zfp558^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	8.33×10^-05
Zfp182 Zfp182^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	8.44×10^-05
Rpia Rpia^{tm1a(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI IMPC	8.53×10^-05
Pex3 Pex3^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	WTSI MGP	8.67×10^-05
Fa2h Fa2h^em1(IMPC)Mbp	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	UC Davis IMPC	9.09×10^-05
Rab3gap2 Rab3gap2^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	9.23×10^-05
Gpr146 Gpr146^em1(IMPC)H	HOM	Late adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	MRC Harwell IMPC	9.42×10^-05
Rad1 Rad1^{tm1b(KOMP)Wtsi}	HET	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	JAX IMPC	9.45×10^-05
Pepd Pepd^{tm1b(KOMP)Wtsi}	HOM	Early adult	decreased circulating HDL cholesterol level	HDL-cholesterol Clinical Chemistry	HMGU IMPC	9.75×10^-05

Download data as: TSV XLS

The way we measure

Procedure
Clinical Blood Chemistry
Clinical Chemistry
Clinical chemistry (GMC)
Fasted Bleed
Fasted Clinical Chemistry
Plasma Chemistry
Terminal Bleed

Phenotype associations stats

2.05% of tested genes with null mutations on a B6N genetic background have a phenotype association to decreased circulating HDL cholesterol level (146/7135)

0.43% females (30/7042) 1.65% males (116/7047)

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Phenotype: decreased circulating HDL cholesterol level

IMPC Gene variants with decreased circulating HDL cholesterol level

The way we measure

Phenotype associations stats

The IMPC Newsletter

Access Data Release 20.1 Data