Gene: Gja8

Order

Name gap junction protein, alpha 8

Synonyms
  • Cnx50
  • connexin 50
  • Aey5
  • Cx50
  • Lop10
  • alpha 8 connexin

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:99953    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Gja8

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Gja8 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
Eye with optic nerve - developmental dysplasia Gja8tm1b(EUCOMM)Hmgu HOM Female Male postnatal 0.0
decreased heart rate variability Gja8tm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.15E-7
cardiovascular system phenotype Gja8tm1b(EUCOMM)Hmgu HOM Female Male postnatal 7.72E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415)
Aorta 4 No
Bone 4 No
Brain 4 No
Brainstem 4 No
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cerebellum 4 No
Cerebral cortex 4 No
Esophagus 4 No (7/415)
Eye 4 No (4/4)
Gall bladder 4 No
Heart 4 No
Hippocampus 4 No
Hypothalamus 4 No
Kidney 4 No (18/584)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Olfactory lobe 4 No
Oral epithelium 4 No
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584)
Parathyroid gland 4 No
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No
Prostate gland 4 No (12/584)
Skeletal muscle 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No
Spleen 4 No (2/584)
Stomach 4 No (12/584)
Striatum 4 No
Testis 4 No (2/584) (2/4)
Thymus 4 No
Thyroid gland 4 No (15/584)
Trachea 4 No
Uterus 4 No
Vascular system 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    sensory organ
    reproductive system
    trunk
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485)
Ear 2 (1/485)
Embryo 2 (1/485) (5/5)
Eye 2 (1/485) (4/5)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Hand 2 (1/485)
Head 2 (5/485) (4/5)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Tail 2 (1/485) (3/5)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    8 Images
  • Echo: M-Mode Images
    20 Images
  • X-ray: XRay Images Lateral Orientation
    8 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    8 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • Adult LacZ: LacZ Images Wholemount
    3 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    1 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Gja8tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Gja8tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene