Gene: Arrb2

Order

Name arrestin, beta 2

Synonyms
  • arrestin 3
  • Arr3
  • beta arr2
  • beta-arrestin2
  • beta-arrestin-2

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:99474    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Arrb2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Arrb2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating alkaline phosphatase level Arrb2tm1.1(KOMP)Vlcg HOM Female postnatal 2.37E-16
increased circulating HDL cholesterol level Arrb2tm1.1(KOMP)Vlcg HOM Female Male postnatal 6.5E-9
increased grip strength Arrb2tm1.1(KOMP)Vlcg HOM Female postnatal 3.87E-6
increased circulating phosphate level Arrb2tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.02E-5
decreased total body fat amount Arrb2tm1.1(KOMP)Vlcg HOM Female Male postnatal 1.24E-5
increased circulating cholesterol level Arrb2tm1.1(KOMP)Vlcg HOM Female Male postnatal 2.65E-5
thrombocytopenia Arrb2tm1.1(KOMP)Vlcg HOM Female postnatal 9.28E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (1/2)
Aorta 2 No (1/562)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (1/2)
Liver 2 No (1/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562) (1/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (1/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (1/2)
Stomach 2 No (9/562) (1/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104) (2/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No (1/2)
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (1/2)
Urinary bladder 2 No
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    digestive system
    set of connective tissues
    reproductive system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/3)
Central nervous system ganglion 1 (1/47) (1/1)
Dorsal root ganglion 1 (1/45) (1/1)
Ear 2 (1/482)
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (1/3)
Foot 2 (1/482)
Forebrain 2 (1/482) (1/3)
Forelimb 2 (1/482)
Fronto-nasal process 1 (1/46) Image Only
Hand 2 (1/482)
Head 2 (5/482) (2/3)
Heart 2 (1/482) (1/3)
Hindbrain 2 (6/482) (2/3)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482) (1/3)
Maxillary process 2 (1/482)
Midbrain 2 (1/482) (2/3)
Nose 1 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Spinal cord 2 (1/46) (2/2)
Tail 2 (1/482) (1/3)
Tail somite 2 (1/482) (1/3)


Associated Images

Associated Images
  • Combined SHIRPA and Dysmorphology
    6 Images
  • Sleep Wake: Wake state (bmp file)
    22 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • Electroretinography: Rod waveform (pdf format)
    8 Images
  • Electroretinography: Cone waveform (pdf format)
    8 Images
  • Eye Morphology: Images Slit Lamp
    5 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Arrb2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Arrb2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Arrb2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene