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Gene: Sct MGI:99466

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
secretin
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sct mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sct by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Type 1 Diabetes Mellitus
Polydipsia, Diabetes mellitus, Polyphagia OMIM:222100
Acquired Central Diabetes Insipidus
Polydipsia, Diabetes insipidus ORPHA:95626
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Hereditary Central Diabetes Insipidus
Polydipsia, Diabetes insipidus ORPHA:30925
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Agitatio... ORPHA:33543
Central Diabetes Insipidus
Polydipsia, Diabetes insipidus, Anorexia ORPHA:178029
Familial Hyperaldosteronism Type I
Adrenal hyperplasia, Abnormal circulating renin, Dexamethasone-suppressible primary hyperaldoster... ORPHA:403
Huntington Disease
Aggressive behavior, Oral-pharyngeal dysphagia, Addictive alcohol use, Agitation, Compulsive beha... ORPHA:399
Hyperaldosteronism, Familial, Type Iii
Polydipsia, Adrenal hyperplasia, Hyperaldosteronism, Decreased circulating renin level OMIM:613677
Brain-Lung-Thyroid Syndrome
Thyroid dysgenesis, Hypoparathyroidism, Thyroid hemiagenesis, Hyperactivity, Abnormal eating beha... ORPHA:209905
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Familial Hyperaldosteronism Type Iii
Adrenal hyperplasia, Glucocortocoid-insensitive primary hyperaldosteronism, Abnormal circulating ... ORPHA:251274
Panhypophysitis
Decreased circulating cortisol level, Polydipsia, Reduced circulating prolactin concentration, Ad... ORPHA:95513
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Methanol Poisoning
Type I diabetes mellitus, Addictive alcohol use, Type II diabetes mellitus ORPHA:31825
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Adrenal hyperplasia, Decreased... ORPHA:231580
Pediatric-Onset Graves Disease
Hyperactivity, Puberty and gonadal disorders, Thyrotoxicosis with diffuse goiter, Increased circu... ORPHA:525731
Cystinosis
Nephrogenic diabetes insipidus, Hypothyroidism, Delayed puberty, Type I diabetes mellitus, Polydi... ORPHA:213
Apparent Mineralocorticoid Excess
Polydipsia, Decreased circulating aldosterone level, Abnormality of circulating cortisol level, D... ORPHA:320
East Syndrome
Polydipsia, Hyperaldosteronism, Increased circulating renin level, Salt craving ORPHA:199343
Bardet-Biedl Syndrome 9
Polydipsia, Polyphagia OMIM:615986
Familial Cold Urticaria
Polydipsia ORPHA:47045
Teratoma, Pineal
Polydipsia OMIM:273120
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Adrenal hyperplasia, Abnormal circulating renin, Hyperaldosteronism, Dexamethasone-suppressible p... ORPHA:369929
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use ORPHA:399180
Pituitary Dermoid And Epidermoid Cysts
Enlarged pituitary gland, Polydipsia, Neoplasm of the anterior pituitary, Hypogonadism, Hyperpitu... ORPHA:91351
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Polydipsia, Diabetes insipidus OMIM:304800
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Nephrogenic diabetes insipidus, Polydipsia OMIM:125800
Marchiafava-Bignami Disease
Addictive alcohol use, Aggressive behavior ORPHA:221074
Ochoa Syndrome
Polydipsia ORPHA:2704
Staphylococcal Necrotizing Pneumonia
Diabetes mellitus, Addictive alcohol use, Increased circulating procalcitonin concentration ORPHA:36238
Isolated Osteopoikilosis
Abnormality of the endocrine system, Addictive alcohol use ORPHA:166119
Septo-Optic Dysplasia Spectrum
Anterior pituitary hypoplasia, Maternal diabetes, Polydipsia, Abnormality of the hypothalamus-pit... ORPHA:3157
Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus, Polydipsia, Anorexia ORPHA:223
Bardet-Biedl Syndrome 17
Polydipsia, Hypogonadism OMIM:615994
Hyperparathyroidism, Neonatal Severe
Primary hyperparathyroidism, Elevated circulating parathyroid hormone level, Polydipsia OMIM:239200
Rabson-Mendenhall Syndrome
Increased pineal volume, Precocious puberty, Insulin-resistant diabetes mellitus, Fasting hyperin... ORPHA:769
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Hyperaldosteronism, Increased circulating renin level, Salt craving OMIM:612780
Acquired Aneurysmal Subarachnoid Hemorrhage
Hypopituitarism, Hypothyroidism, Addictive alcohol use ORPHA:90065
Acute Lung Injury
Addictive alcohol use ORPHA:178320
Nephronophthisis 4
Polydipsia OMIM:606966
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Whipple Disease
Polydipsia, Hypothyroidism, Anorexia ORPHA:3452
Herpes Simplex Virus Encephalitis
Addictive alcohol use ORPHA:1930
Nephronophthisis 3
Polydipsia OMIM:604387
Acute Promyelocytic Leukemia
Addictive alcohol use, Anorexia ORPHA:520
Nephronophthisis 1
Polydipsia OMIM:256100
Hyperparathyroidism-Jaw Tumor Syndrome
Primary hyperparathyroidism, Abnormal parathyroid morphology, Elevated circulating parathyroid ho... ORPHA:99880
Helix Syndrome
Hyperparathyroidism, Polydipsia OMIM:617671
Wolfram Syndrome
Diabetes mellitus, Hypogonadism, Delayed puberty, Male hypogonadism, Polydipsia, Diabetes insipidus ORPHA:3463
Parathyroid Carcinoma
Primary hyperparathyroidism, Abnormal parathyroid morphology, Elevated circulating parathyroid ho... ORPHA:143
Gitelman Syndrome
Polydipsia, Salt craving, Increased circulating renin level, Delayed puberty OMIM:263800
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Decreased response to growth hormone stimulation test, Central diabetes insipidus, Aggressive beh... ORPHA:293987
Nephronophthisis 11
Polydipsia OMIM:613550
Porphyria Cutanea Tarda
Diabetes mellitus, Addictive alcohol use ORPHA:101330
Hypomagnesemia 3, Renal
Polydipsia, Elevated circulating parathyroid hormone level OMIM:248250
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Gitelman Syndrome
Salt craving, Maternal diabetes, Diabetic ketoacidosis, Type I diabetes mellitus, Type II diabete... ORPHA:358
Renal Hypoplasia
Polydipsia ORPHA:93101
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Abnormality of endocrine pancreas physiology, Polydipsia, Diabetes mellitus, Hypothyroidism ORPHA:93111
Cirrhotic Cardiomyopathy
Addictive alcohol use ORPHA:57777
Erdheim-Chester Disease
Polydipsia, Hypogonadotropic hypogonadism, Diabetes insipidus ORPHA:35687
Infantile Nephropathic Cystinosis
Polydipsia, Abnormality of thyroid physiology ORPHA:411629
Oligomeganephronia
Polydipsia ORPHA:2260
Toxic Epidermal Necrolysis
Polydipsia, Dysphagia ORPHA:537
Cystinosis, Nephropathic
Diabetes mellitus, Oral-pharyngeal dysphagia, Dysphagia, Primary hypothyroidism, Delayed puberty,... OMIM:219800
Ethylene Glycol Poisoning
Addictive alcohol use ORPHA:31826
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia, Hyperaldosteronism OMIM:602522
Juvenile Nephropathic Cystinosis
Polydipsia, Hypothyroidism ORPHA:411634
Bartter Syndrome, Type 2, Antenatal
Polydipsia, Hyperactive renin-angiotensin system, Hyperaldosteronism, Increased circulating renin... OMIM:241200
Distal Renal Tubular Acidosis
Polydipsia ORPHA:18
Arima Syndrome
Polydipsia OMIM:243910
Autosomal Recessive Polycystic Kidney Disease
Polydipsia ORPHA:731
Proximal Renal Tubular Acidosis
Polydipsia ORPHA:47159

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sct

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sct.

No publications found that use IMPC mice or data for Sct.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Scttm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Scttm3(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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