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Genes Phenotypes Help, News, Blog

Gene: Pigf MGI:99462

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Gene Summary

Name:
phosphatidylinositol glycan anchor biosynthesis, class F
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Pigftm1a(KOMP)Wtsi HET Early adult 1.79×10-05
preweaning lethality, complete penetrance Pigftm1a(KOMP)Wtsi HOM   Early adult 0.00
decreased bone mineral content Pigftm1a(KOMP)Wtsi HET Early adult 2.08×10-05
increased total body fat amount Pigftm1a(KOMP)Wtsi HET Early adult 2.30×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Forepaw

5 Images

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Anti-nuclear antibody assay

Images

6 Images

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X-ray

XRay Images Whole Body Lateral Orientation

5 Images

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X-ray

XRay Images Whole Body Dorso Ventral

5 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

5 Images

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X-ray

XRay Images Skull Lateral Orientation

5 Images

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DSS Histology

Images

8 Images

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Eye Morphology

Images Slit Lamp

3 Images

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Ear epidermis immunophenotyping

Images

11 Images

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Legacy Phenotype Associated Images
Pigftm1a(KOMP)Wtsi
WT, Female, WTSI
Pigftm1a(KOMP)Wtsi
WT, Female, WTSI
Pigftm1a(KOMP)Wtsi
WT, Female, WTSI
Pigftm1a(KOMP)Wtsi
WT, Female, WTSI
Pigftm1a(KOMP)Wtsi
WT, Female, WTSI

View all 176 images

Pigftm1a(KOMP)Wtsi
abnormal digit morphology, WT, Male, WTSI
Pigftm1a(KOMP)Wtsi
joint swelling, HET, Male, WTSI
Pigftm1a(KOMP)Wtsi
abnormal digit morphology, WT, Male, WTSI
Pigftm1a(KOMP)Wtsi
abnormal placement of pupils, HET, Male, WTSI
Pigftm1a(KOMP)Wtsi
abnormal cornea morphology, HET, Female, WTSI
Pigftm1a(KOMP)Wtsi
abnormal cornea morphology, HET, Female, WTSI

Human diseases caused by Pigf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Pigf by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome
OMIM:619356

The table below shows human diseases predicted to be associated to Pigf by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Onychodystrophy, Osteodystrophy, Impaired Intellectual Development, And Seizures Syndrome
OMIM:619356

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pigf

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pigf.

There are 5 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Pigftm1a(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Pigftm1a(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Pigftm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Pigftm1a(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Pigftm1a(KOMP)Wtsi PMC5827107

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Pigftm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Pigftm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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