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Gene: Piga MGI:99461

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
phosphatidylinositol glycan anchor biosynthesis, class A
Synonyms:
Pig-a,  phosphatidylinositolglycan class A

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Piga mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Piga by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Paroxysmal Nocturnal Hemoglobinuria 1
OMIM:300818
Infantile Spasms Syndrome
ORPHA:3451
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
OMIM:301072
Malignant Migrating Focal Seizures Of Infancy
ORPHA:293181
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
OMIM:300868
Paroxysmal Nocturnal Hemoglobinuria
ORPHA:447

The table below shows human diseases predicted to be associated to Piga by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Joubert Syndrome 15
Exencephaly OMIM:614464
Neural Tube Defects, Susceptibility To
Hydrocephalus, Spina bifida occulta, Anencephaly, Myelomeningocele OMIM:182940
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Ollier Disease
Multiple enchondromatosis, Abnormal cartilage morphology ORPHA:296
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Exencephaly ORPHA:2211
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Lethal Kniest-Like Dysplasia
Wide anterior fontanel, Abnormal cartilage morphology, Abnormal cartilage matrix ORPHA:2347
Spondyloepiphyseal Dysplasia Tarda
Abnormal cartilage morphology ORPHA:93284
Multiple Osteochondromas
Cervical myelopathy, Abnormal cartilage morphology ORPHA:321
Encephalocraniocutaneous Lipomatosis
Abnormal cartilage morphology ORPHA:2396
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
OMIM:300868
Paroxysmal Nocturnal Hemoglobinuria 1
OMIM:300818
Infantile Spasms Syndrome
ORPHA:3451
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
OMIM:301072
Malignant Migrating Focal Seizures Of Infancy
ORPHA:293181
Paroxysmal Nocturnal Hemoglobinuria
ORPHA:447

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Piga

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Piga.

No publications found that use IMPC mice or data for Piga.

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