Gene: Thra

Order

Name thyroid hormone receptor alpha

Synonyms
  • Erba
  • TR alpha 2
  • c-erbAalpha
  • 6430529J03Rik
  • TR alpha 1
  • Rvr
  • Nr1a1
  • Thra2
  • Thra1
  • T3Ralpha
  • T3R[a]

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:98742    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Thra

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Thra data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Thratm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
increased bone mineral content Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 2.94E-15
abnormal behavior Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 4.0E-13
decreased total retina thickness Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 1.1E-10
increased startle reflex Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 1.27E-9
hyperactivity Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 2.61E-8
decreased grip strength Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 5.63E-8
decreased total body fat amount Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 2.17E-7
increased circulating alkaline phosphatase level Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 1.16E-6
decreased body length Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 3.53E-6
limb grasping Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 5.09E-6
abnormal retinal inner nuclear layer morphology Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 1.4E-5
abnormal behavioral response to light Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 3.01E-5
abnormal eye anterior chamber depth Thratm1b(EUCOMM)Wtsi HET Female Male postnatal 4.13E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Epididymis 2 No (4/106) (1/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562) (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Midbrain 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562) (2/2)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Submandibular gland 2 No (1/104) (2/2)
Testis 2 No (4/562) (1/2)
Thalamus 2 No (2/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vascular system 2 No (1/393) (2/2)
Vesicular gland 2 No
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    adipose tissue
    trunk
    postnatal mouse
    nervous system
    sensory organ
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482) (2/3)
Dorsal root ganglion 2 (1/45) Image Only
Ear 2 (1/482) Image Only
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (2/3)
Foot 2 (1/482) (2/3)
Forebrain 2 (1/482) (2/3)
Forelimb 2 (1/482) (2/3)
Fronto-nasal process 2 (1/46) Image Only
Hand 2 (1/482) (2/3)
Head 2 (5/482) (2/3)
Heart 2 (1/482) (2/3)
Hindbrain 2 (6/482) (2/3)
Hindlimb 2 (1/482) (2/3)
Liver 2 (1/482) Image Only
Lung 2 (1/482) Image Only
Mandibular process 2 (1/482) (2/3)
Maxillary process 2 (1/482) (2/3)
Midbrain 2 (1/482) (2/3)
Nose 2 (1/47) (2/2)
Oral cavity 2 (1/482) Image Only
Skin 2 (1/482) (2/3)
Spinal cord 2 (1/46) (2/2)
Tail 2 (1/482) (2/3)
Tail somite 2 (1/482) (2/3)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    18 Images
  • X-ray: XRay Images Forepaw
    8 Images
  • X-ray: XRay Images Dorso Ventral
    18 Images
  • X-ray: XRay Images Skull Lateral Orientation
    8 Images
  • Embryo LacZ: LacZ images wholemount
    12 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    8 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Thratm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Thratm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Thratm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Thratm43807(L1L2_gt1)
Vector
Gene
Thratm357(L1L2_gt2)
Vector
Gene