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Gene: Syp MGI:98467

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Gene Summary

Name:
synaptophysin
Synonyms:
Syp I,  Syn,  A230093K24Rik,  p38

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased vertical activity Sypem1(IMPC)Bay HET Early adult 1.52×10-07
increased vertical activity Sypem1(IMPC)Bay HEM Early adult 8.40×10-07
abnormal retina outer nuclear layer morphology Sypem1(IMPC)Bay HEM Early adult 9.44×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right fundus

17 Images

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Eye Morphology

VIP of left fundus

18 Images

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Eye Morphology

VIP of left eye

18 Images

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Eye Morphology

VIP of right eye

18 Images

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Human diseases caused by Syp mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Syp by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked 96
OMIM:300802

The table below shows human diseases predicted to be associated to Syp by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Schizophrenia 15
Hyperactivity OMIM:613950
Retinal Dysplasia, Primary
Retinal dysplasia, Falciform retinal fold OMIM:312550
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Gilles De La Tourette Syndrome
Aggressive behavior, Phonic tics, Attention deficit hyperactivity disorder, Compulsive behaviors,... OMIM:137580
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Stargardt Disease 1
Macular degeneration, Retinitis pigmentosa inversa, Bull's eye maculopathy OMIM:248200
Night Blindness, Congenital Stationary, Type 1D
Congenital stationary night blindness, Pigmentary retinopathy, Macular atrophy, Attenuation of re... OMIM:613830
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Reese Retinal Dysplasia
Remnants of the hyaloid vascular system, Retinal dysplasia OMIM:266400
Histidinemia
Hyperactivity ORPHA:2157
Intellectual Developmental Disorder, X-Linked 96
OMIM:300802

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Syp

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Syp.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility. Nature communications (August 2023) Sypltm1b(KOMP)Wtsi  PMC10444883

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Syptm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Syptm40672(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Syptm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Sypem1(IMPC)Bay Exon Deletion Mice

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