Gene: Pcx

Name pyruvate carboxylase

Synonyms Pc

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:97520   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Pcx

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Pcx data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Pcxtm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased lean body mass Pcxtm1b(EUCOMM)Wtsi HET Female Male postnatal 5.75E-6
decreased red blood cell distribution width Pcxtm1b(EUCOMM)Wtsi HET Female Male postnatal 5.71E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (5/393) (2/4)
Aorta 4 No (1/562)
Blood 2 No
Bone 4 No (1/539)
Bone marrow 2 No
Brain 4 No (6/562) (4/4)
Brainstem 4 No (4/562) (2/4)
Brown adipose tissue 4 No (4/4)
Cartilage tissue 4 No (1/562)
Cecum 2 No (1/355)
Cerebellum 4 No (4/562) (2/4)
Cerebral cortex 4 No (5/562)
Chest bone 2 No (2/2)
Colon 2 No (1/99)
Cranium 2 No
Diaphragm 2 No
Epididymis 2 No (4/106)
Esophagus 4 No (2/393)
Eye 4 No (1/562)
Gall bladder 4 No (1/4)
Harderian gland 2 No
Heart 4 No (3/562)
Hindlimb 2 No
Hippocampus 4 No (5/562) (2/4)
Hypothalamus 4 No (4/562) (2/4)
Kidney 4 No (20/562) (4/4)
Large intestine 4 No (12/562)
Liver 4 No (2/4)
Lower urinary tract 4 No (3/562) (2/4)
Lung 4 No (3/562) (3/4)
Lymph node 4 No (1/562) (1/4)
Main olfactory bulb 2 No
Mammary gland 4 No (1/4)
Mesenteric lymph node 2 No
Olfactory lobe 4 No (4/393) (2/4)
Oral epithelium 4 No
Ovary 4 No (1/562) (1/4)
Oviduct 4 No (2/562) (1/4)
Pancreas 4 No (6/562) (3/4)
Parathyroid gland 4 No (2/540) (2/4)
Parotid gland 2 No
Penis 2 No
Peripheral nervous system 4 No (3/562) (2/4)
Peyer's patch 4 No (1/393)
Pituitary gland 4 No (1/562)
Prostate gland 4 No (5/562)
Sciatic nerve 2 No
Skeletal muscle 4 No (2/4)
Skin 4 No (1/562) (4/4)
Small intestine 4 No (11/562)
Spinal cord 4 No (3/562) (2/4)
Spleen 4 No (4/562)
Stomach 4 No (9/562) (4/4)
Stomach pyloric region 2 No
Striatum 4 No (4/562)
Sublingual gland 2 No
Submandibular gland 2 No (1/104)
Testis 4 No (4/562) (2/4)
Thymus 4 No (2/4)
Thyroid gland 4 No (16/562) (2/4)
Tongue 2 No
Trachea 4 No (3/562)
Trigeminal V nerve 2 No
Urinary bladder 2 No
Uterus 4 No (2/562)
Vagina 2 No
Vas deferens 2 No (1/360)
Vascular system 4 No (1/393)
Vesicular gland 2 No
White adipose tissue 4 No (3/4)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system
    endocrine system
    digestive system
    set of connective tissues
    reproductive system
    adipose tissue
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    20 Images
  • X-ray: XRay Images Dorso Ventral
    20 Images
  • Adult LacZ: LacZ Images Wholemount
    38 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Echo: M-Mode Images
    32 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Pcxtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Pcxtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Pcxtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene