Gene: Nhlh2

Order

Name nescient helix loop helix 2

Synonyms
  • NSCL2
  • 6230401I09Rik
  • bHLHa34
  • Hen2
  • Nscl-2

Status ES CellsMice
em1
Mice
tm1a
Mice
tm1b
phenotype data available

Links MGI:97324    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Nhlh2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nhlh2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal epididymis morphology Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
abnormal ovary morphology Nhlh2tm1b(KOMP)Mbp HOM Female postnatal 0.0
abnormal seminal vesicle morphology Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
abnormal testis morphology Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
absent epididymis Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
absent ovary Nhlh2tm1b(KOMP)Mbp HOM Female postnatal 0.0
absent seminal vesicle Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
absent testes Nhlh2tm1b(KOMP)Mbp HOM Male postnatal 0.0
female infertility Nhlh2tm1b(KOMP)Mbp HOM Female postpartum stage 0.0
female infertility Nhlh2em1(IMPC)Mbp HOM Female postpartum stage 0.0
male infertility Nhlh2em1(IMPC)Mbp HOM Male postpartum stage 0.0
male infertility Nhlh2tm1b(KOMP)Mbp HOM Male postpartum stage 0.0
small superior vagus ganglion Nhlh2tm1b(KOMP)Mbp HOM Female postnatal 0.0
small uterus Nhlh2tm1b(KOMP)Mbp HOM Female postnatal 0.0
decreased bone mineral density Nhlh2tm1b(KOMP)Mbp HOM Female Male postnatal 2.28E-26
decreased bone mineral content Nhlh2tm1b(KOMP)Mbp HOM Female Male postnatal 5.98E-17
decreased bone mineral density Nhlh2em1(IMPC)Mbp HOM Female Male postnatal 3.19E-10
abnormal bone structure Nhlh2tm1b(KOMP)Mbp HOM Female Male postnatal 7.88E-10
decreased bone mineral content Nhlh2em1(IMPC)Mbp HOM Female postnatal 6.3E-8
impaired glucose tolerance Nhlh2em1(IMPC)Mbp HOM Female Male postnatal 5.65E-7

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No (2/415)
Aorta 4 No
Blood 4 No
Bone marrow 4 No
Brain 4 No (1/4)
Brainstem 4 No
Brown adipose tissue 4 No
Cartilage tissue 4 No
Cecum 4 No (12/383) (1/4)
Cerebellum 4 No (3/4)
Cerebral cortex 4 No
Chest bone 4 No
Colon 4 No (12/127) (1/4)
Diaphragm 4 No
Duodenum 4 No (2/127)
Epididymis 4 No (18/134) (3/4)
Esophagus 4 No (7/415) (1/4)
Eye 4 No (1/4)
Gall bladder 4 No
Gonadal fat pad 4 No
Harderian gland 4 No
Heart 4 No
Hindlimb 4 No
Hippocampus 4 No
Hypothalamus 4 No
Ileum 4 No (14/127) (2/4)
Jejunum 4 No (6/127) (1/4)
Kidney 4 No (18/584)
Large intestine 4 No (10/584)
Liver 4 No
Lower urinary tract 4 No
Lung 4 No
Lymph node 4 No
Mammary gland 4 No
Mesenteric lymph node 4 No
Mesenteric adipose tissue 4 No
Midbrain 4 No (4/4)
Olfactory lobe 4 No (1/4)
Ovary 4 No (1/584)
Oviduct 4 No
Pancreas 4 No (5/584)
Parathyroid gland 4 No
Parotid gland 4 No
Penis 4 No
Peripheral nervous system 4 No
Peyer's patch 4 No
Pituitary gland 4 No (1/4)
Prostate gland 4 No (12/584)
Quadriceps 4 No
Sciatic nerve 4 No
Skeletal muscle 4 No
Skin 4 No
Small intestine 4 No (9/584)
Spinal cord 4 No (1/4)
Spleen 4 No (2/584)
Stomach 4 No (12/584) (1/4)
Stomach pyloric region 4 No
Striatum 4 No
Sublingual gland 4 No
Submandibular gland 4 No (2/132)
Testis 4 No (2/584) (3/4)
Thymus 4 No
Thyroid gland 4 No (15/584) (1/4)
Tongue 4 No (5/127)
Trachea 4 No (1/4)
Trigeminal V nerve 4 No
Urinary bladder 4 No
Uterus 4 No
Vagina 4 No
Vas deferens 4 No (15/388) (2/4)
Vascular system 4 No
Vesicular gland 4 No
White adipose tissue 4 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse respiratory system endocrine system digestive system nervous system sensory organ reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    30 Images
  • X-ray: XRay Images Dorso Ventral
    50 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nhlh2em1(IMPC)Mbp Indel causing a Frameshift Mutation
Vector
Gene
Fixed Tissue
Nhlh2tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nhlh2tm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue