Gene: Mdk

Order

Name midkine

Synonyms
  • MK
  • Mek

Status ES CellsMice
tm1
Mice
tm1.1
phenotype data available

Links MGI:96949    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for Mdk

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Mdk data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Mdktm1.1(KOMP)Mbp HOM Female Male n/a 0.0
decreased lean body mass Mdktm1.1(KOMP)Mbp HOM Male postnatal 1.32E-5
abnormal bone structure Mdktm1.1(KOMP)Mbp HOM Female Male postnatal 1.38E-5
increased grip strength Mdktm1.1(KOMP)Mbp HOM Male postnatal 3.63E-5
decreased bone mineral content Mdktm1.1(KOMP)Mbp HOM Female Male postnatal 3.79E-5
decreased bone mineral density Mdktm1.1(KOMP)Mbp HOM Female Male postnatal 6.89E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393)
Aorta 2 No (1/562)
Brain 2 No (6/562)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Epididymis 2 No (4/106)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Midbrain 2 No
Olfactory lobe 2 No (4/393)
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562)
Pancreas 2 No (6/562)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562)
Spinal cord 2 No (3/562)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562)
Striatum 2 No (4/562)
Submandibular gland 2 No (1/104)
Testis 2 No (4/562) (1/2)
Thalamus 2 No
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562) (2/2)
Urinary bladder 2 No
Uterus 2 No (2/562)
Vascular system 2 No (1/393)
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    respiratory system
    reproductive system
    immune system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Dorsal root ganglion 1 (1/45) Image Only
Ear 2 (1/482)
Embryo 2 (1/482) (2/3)
Eye 2 (1/482) (2/3)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Fronto-nasal process 1 (1/46)
Hand 2 (1/482)
Head 2 (5/482) (2/3)
Heart 2 (1/482)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482) Image Only
Mandibular process 2 (1/482) (1/3)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Nose 1 (1/47)
Oral cavity 2 (1/482)
Skin 2 (1/482) (2/3)
Spinal cord 1 (1/46)
Tail 2 (1/482)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • Sleep Wake: Wake state (bmp file)
    19 Images
  • Electroretinography 2: Rod and cone PDF
    6 Images
  • X-ray: XRay Images Dorso Ventral
    21 Images
  • X-ray: XRay Images Forepaw
    21 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Skull Lateral Orientation
    21 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    21 Images
  • X-ray: XRay Images Lateral Orientation
    21 Images
  • Combined SHIRPA and Dysmorphology
    5 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Mdktm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Mdktm1.1(KOMP)Mbp Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Mdktm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene