Gene: Ica1

Order

Name islet cell autoantigen 1

Synonyms
  • ICA69
  • 69kDa

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:96391    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Ica1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Ica1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal cecum morphology Ica1tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
abnormal eye morphology Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
abnormal kidney morphology Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
abnormal seminal vesicle morphology Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
abnormal spleen morphology Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
enlarged cecum Ica1tm1b(EUCOMM)Wtsi HOM Female Male postnatal 0.0
enlarged kidney Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
small spleen Ica1tm1b(EUCOMM)Wtsi HOM Male postnatal 0.0
decreased total body fat amount Ica1tm1b(EUCOMM)Wtsi HOM Female Male postnatal 8.55E-8
decreased lean body mass Ica1tm1b(EUCOMM)Wtsi HOM Female Male postnatal 4.17E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No
Blood 2 No
Bone marrow 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cecum 2 No (12/383)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127) (2/2)
Diaphragm 2 No
Duodenum 2 No (2/127)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No (2/2)
Gall bladder 2 No
Gonadal fat pad 2 No
Harderian gland 2 No
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127) (1/2)
Jejunum 2 No (6/127)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No
Midbrain 2 No (2/2)
Olfactory lobe 2 No (2/2)
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584) (1/2)
Parathyroid gland 2 No (1/2)
Parotid gland 2 No (1/2)
Penis 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No (1/2)
Submandibular gland 2 No (2/132) (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Tongue 2 No (5/127)
Trachea 2 No (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No
Vagina 2 No
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No (1/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system postnatal mouse respiratory system digestive system nervous system sensory organ reproductive system exocrine system trunk urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Ica1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Ica1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Fixed Tissue
Ica1tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene