Gene: Gna11

Order

Name guanine nucleotide binding protein, alpha 11

Synonyms Dsk7

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:95766    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Gna11

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Gna11 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased circulating calcium level Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 9.78E-33
decreased hemoglobin content Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.26E-24
decreased hemoglobin content Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.42E-24
decreased circulating amylase level Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.19E-13
decreased hematocrit Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.62E-11
decreased body weight Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 5.32E-10
decreased erythrocyte cell number Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 1.65E-9
increased red blood cell distribution width Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 7.72E-9
decreased bone mineral content Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 3.85E-7
decreased bone mineral density Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.03E-7
decreased circulating triglyceride level Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.06E-6
decreased circulating phosphate level Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 1.2E-6
vertebral fusion Gna11tm1b(EUCOMM)Wtsi HOM Male postnatal 1.25E-6
short tibia Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 6.1E-6
decreased circulating total protein level Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 2.42E-5
decreased bone mineral density Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 3.94E-5
abnormal behavior Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 4.73E-5
abnormal bone mineralization Gna11tm1a(EUCOMM)Wtsi HOM Female Male postnatal 7.11E-5
increased fasted circulating glucose level Gna11tm1b(EUCOMM)Wtsi HOM Female Male postnatal 7.74E-5
increased startle reflex Gna11tm1a(EUCOMM)Wtsi HOM Male postnatal 9.04E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562)
Bone 2 No (1/539)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562)
Cerebellum 2 No (4/562)
Cerebral cortex 2 No (5/562)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562)
Hippocampus 2 No (5/562)
Hypothalamus 2 No (4/562)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562)
Lymph node 2 No (1/562)
Mammary gland 2 No
Olfactory lobe 2 No (4/393)
Oral epithelium 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No
Skin 2 No (1/562)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562)
Trachea 2 No (3/562)
Uterus 2 No (2/562)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    postnatal mouse
    digestive system
    cardiovascular system
    nervous system
    reproductive system
    exocrine system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/482)
Ear 2 (1/482)
Embryo 2 (1/482) (3/4)
Eye 2 (1/482)
Foot 2 (1/482)
Forebrain 2 (1/482)
Forelimb 2 (1/482)
Hand 2 (1/482)
Head 2 (5/482) (1/4)
Heart 2 (1/482)
Hindbrain 2 (6/482)
Hindlimb 2 (1/482)
Liver 2 (1/482)
Lung 2 (1/482)
Mandibular process 2 (1/482)
Maxillary process 2 (1/482)
Midbrain 2 (1/482)
Oral cavity 2 (1/482)
Skin 2 (1/482)
Tail 2 (1/482) (3/4)
Tail somite 2 (1/482)


Associated Images

Associated Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Lateral Orientation
    12 Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Dorso Ventral
    12 Images
  • Adult LacZ: LacZ Images Wholemount
    15 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Gna11tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Gna11tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene