Gene: Cyp19a1

Order

Name cytochrome P450, family 19, subfamily a, polypeptide 1

Synonyms
  • ArKO
  • p450arom
  • Cyp19
  • aromatase
  • Int5
  • Ar
  • Int-5

Status ES CellsMice
tm1b
Mice
tm1a
phenotype data available

Links MGI:88587    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Cyp19a1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Cyp19a1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
decreased bone mineral density Cyp19a1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 3.92E-6
decreased grip strength Cyp19a1tm1b(EUCOMM)Hmgu HOM Female postnatal 4.23E-6
increased grip strength Cyp19a1tm1b(EUCOMM)Hmgu HOM Male postnatal 4.23E-6
abnormal behavior Cyp19a1tm1b(EUCOMM)Hmgu HOM Female postnatal 1.51E-5
hypoactivity Cyp19a1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 1.9E-5
increased total body fat amount Cyp19a1tm1b(EUCOMM)Hmgu HOM Female Male postnatal 8.72E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No (1/2)
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584) (1/2)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
Vascular system 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse digestive system nervous system reproductive system trunk
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Phenotype associated images not available

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Cyp19a1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Cyp19a1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene