Gene: Chd1

Name chromodomain helicase DNA binding protein 1

Synonyms 4930525N21Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:88393   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Lethal

Phenotype associations for Chd1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Chd1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET Female embryonic day 12.5 0.0
abnormal embryo size Chd1tm1b(KOMP)Wtsi HET Female Male embryonic day 9.5 0.0
abnormal eye morphology Chd1tm1b(KOMP)Wtsi HET Female Male embryonic day 12.5 0.0
anophthalmia Chd1tm1b(KOMP)Wtsi HET Male postnatal 0.0
embryonic growth retardation Chd1tm1b(KOMP)Wtsi HET Male embryonic day 9.5 0.0
embryonic lethality prior to organogenesis Chd1tm1b(KOMP)Wtsi HOM Female Male embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Chd1tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Chd1tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased red blood cell distribution width Chd1tm1b(KOMP)Wtsi HET Female Male postnatal 2.35E-6
decreased lean body mass Chd1tm1b(KOMP)Wtsi HET Male postnatal 3.38E-6
abnormal maxilla morphology Chd1tm1b(KOMP)Wtsi HET Male postnatal 1.58E-5
abnormal tooth morphology Chd1tm1b(KOMP)Wtsi HET Male postnatal 1.58E-5
decreased bone mineral density Chd1tm1b(KOMP)Wtsi HET Female Male postnatal 1.78E-5
decreased hemoglobin content Chd1tm1b(KOMP)Wtsi HET Female postnatal 2.25E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
No expression data was found for this adult tab
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 12 (6/440) Image Only
Ear 12 (1/440) Image Only
Embryo 12 (1/440) Image Only
Eye 12 (1/440) Image Only
Foot 12 Image Only
Forebrain 12 (1/440) Image Only
Forelimb 12 (1/440) Image Only
Hand 12 Image Only
Head 12 (5/440) Image Only
Heart 12 (1/440) Image Only
Hindbrain 12 (5/440) Image Only
Hindlimb 12 (1/440) Image Only
Liver 12 (1/440) Image Only
Lung 12 (1/440) Image Only
Mandibular process 12 (1/440) Image Only
Maxillary process 12 (1/440) Image Only
Midbrain 12 (1/440) Image Only
Oral cavity 12 (1/440) Image Only
Skin 12 (1/440) Image Only
Tail 12 (1/440) Image Only
Tail somite 12 (1/440) Image Only


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    48 Images
  • Gross Pathology and Tissue Collection
    8 Images
  • X-ray: XRay Images Lateral Orientation
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    12 Images
  • X-ray: XRay Images Dorso Ventral
    12 Images
  • X-ray: XRay Images Hind Leg and Hip
    2 Images
  • Histopathology
    1 Images
  • Combined SHIRPA and Dysmorphology
    4 Images
  • Eye Morphology: Images Slit Lamp
    3 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Chd1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Chd1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene