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Gene: Bmp1 MGI:88176

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Gene Summary

Name:
bone morphogenetic protein 1
Synonyms:
N/A

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Bmp1em1(IMPC)Bay HOM   Early adult 0.00
abnormal body wall morphology Bmp1em1(IMPC)Bay HOM E18.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Bmp1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Bmp1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia, Dentinogenesis imperfecta OMIM:614856

The table below shows human diseases predicted to be associated to Bmp1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Gastroschisis
Gastroschisis, Intestinal atresia ORPHA:2368
Gastroschisis
Abdominal wall defect, Gastroschisis OMIM:230750
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly, Cleft palate, Ectopic anus, Gastroschisis ORPHA:2476
Colonic Atresia
Omphalocele, Peptic ulcer, Duodenal stenosis, Gastroschisis, Colonic atresia ORPHA:1198
Secondary Short Bowel Syndrome
Abnormal small intestine morphology, Villous atrophy, Aganglionic megacolon, Small intestinal dys... ORPHA:95427
Hypoglossia-Hypodactyly Syndrome
Death in infancy, Jejunal atresia, Aplasia/Hypoplasia of the tongue, Micrognathia, Cleft palate, ... ORPHA:989
Iniencephaly
Encephalocele, Omphalocele, Spina bifida, Myelomeningocele, Anencephaly, Spinal dysraphism, Gastr... ORPHA:63259
Gm1 Gangliosidosis
Mandibular prognathia, Inguinal hernia, Aplasia/Hypoplasia of the abdominal wall musculature, Mac... ORPHA:354
Constricting Bands, Congenital
Encephalocele, Omphalocele, Cleft palate, Gastroschisis, Bladder exstrophy OMIM:217100
Acrofacial Dysostosis 1, Nager Type
Aganglionic megacolon, Micrognathia, Trismus, Velopharyngeal insufficiency, Temporomandibular joi... OMIM:154400
Necrotizing Enterocolitis
Gastroschisis ORPHA:391673
Frontonasal Dysplasia-Severe Microphthalmia-Severe Facial Clefting Syndrome
Hypoplasia of the maxilla, Cranium bifidum occultum, Hypoplasia of the frontal bone, Cleft palate ORPHA:306542
Duplication Of Urethra
Rectourethral fistula, Anorectal anomaly, Gastroschisis, Anal fistula, Anal atresia ORPHA:237
Smith-Lemli-Opitz Syndrome
Aganglionic megacolon, Abnormal dental enamel morphology, Micrognathia, Pyloric stenosis, Supernu... ORPHA:818
Isolated Exencephaly
Hypoplasia of the frontal bone ORPHA:563612
Frontofacionasal Dysplasia
Cranium bifidum occultum, Bifid uvula, Hypoplasia of the frontal bone OMIM:229400
Tetraamelia Syndrome 1
Anal atresia, Gastroschisis, Cleft palate, Micrognathia OMIM:273395
Hartsfield Syndrome
Hypoplasia of the frontal bone, Cleft palate OMIM:615465
Osteogenesis Imperfecta, Type Xiii
Umbilical hernia, Dentinogenesis imperfecta OMIM:614856

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Bmp1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Bmp1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Warning regarding hematological toxicity of tamoxifen activated CreERT2 in young Rosa26CreERT2 mice. Scientific reports (April 2023) Bmp10tm3c(EUCOMM)Hmgu PMC10097815
Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10. Cardiovascular research (June 2022) Bmp10tm3c(EUCOMM)Hmgu PMC9215199
BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer. Journal of experimental & clinical cancer research : CR (August 2018) Bmp10tm3c(EUCOMM)Hmgu PMC6118004
Inactivation of bone morphogenetic protein 1 (Bmp1) and tolloid-like 1 (Tll1) in cells expressing type I collagen leads to dental and periodontal defects in mice. Journal of molecular histology (December 2016) Bmp1tm1a(KOMP)Wtsi PMC6635762

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Bmp1em1(IMPC)Bay Exon Deletion Mice
Bmp1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bmp1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells

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