Gene: App

Order

Name amyloid beta (A4) precursor protein

Synonyms
  • Abeta
  • appican
  • Adap
  • protease nexin II
  • betaAPP
  • Cvap
  • E030013M08Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:88059    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Subviable

Phenotype associations for App

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all App data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
premature death Apptm1b(KOMP)Wtsi HOM Female Male n/a 0.0
preweaning lethality, incomplete penetrance Apptm1b(KOMP)Wtsi HOM Female Male n/a 0.0
increased blood urea nitrogen level Apptm1b(KOMP)Wtsi HET Female Male postnatal 1.58E-7
decreased circulating bilirubin level Apptm1b(KOMP)Wtsi HET Female Male postnatal 9.04E-7

Download data as: TSV XLS



Expression

Expression data not available

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Apptm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Apptm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene