Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased exploration in new environment | Wee2em1(IMPC)J | HOM | Early adult | 4.57×10-08 | ||
decreased locomotor activity | Wee2em1(IMPC)J | HOM | Early adult | 3.85×10-05 | ||
decreased bone mineral density | Wee2em1(IMPC)J | HOM | Early adult | 7.19×10-05 | ||
decreased circulating iron level | Wee2em1(IMPC)J | HOM | Early adult | 3.60×10-06 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Wee2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Oocyte/Zygote/Embryo Maturation Arrest 5 | Lack of oocyte pronucleus formation, Female infertility | OMIM:617996 | |
Female Infertility Due To Oocyte Meiotic Arrest | Abnormal spermatogenesis, Oocyte arrest at metaphase I, Abnormal meiosis, Female infertility | ORPHA:488191 |
The table below shows human diseases predicted to be associated to Wee2 by phenotypic similarity.
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MGI Allele | Allele Type | Produced |
---|---|---|
Wee2em1(IMPC)J | Indel | Mice |
Wee2tm41904(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
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