Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal heart morphology | Asb16em1(IMPC)Ccpcz | HOM | Early adult | 0.00 | ||
enlarged thymus | Asb16em1(IMPC)Ccpcz | HOM | Early adult | 0.00 | ||
abnormal heart shape | Asb16em1(IMPC)Ccpcz | HOM | Early adult | 0.00 | ||
abnormal lens morphology | Asb16em1(IMPC)Ccpcz | HOM | Early adult | 4.58×10-05 | ||
abnormal thymus morphology | Asb16em1(IMPC)Ccpcz | HOM | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Asb16 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Anterior Segment Dysgenesis 8 | Microphakia, Iris transillumination defect, Iridodonesis, Corneal stromal edema, Corneal opacity,... | OMIM:617319 | |
Exfoliation Syndrome | Mydriasis, Phakodonesis, Iris hypoperfusion, Anisocoria, Pigment deposition in the trabecular mes... | OMIM:177650 | |
Proteus-Like Syndrome | Heterochromia iridis, Cataract, Splenomegaly, Thymus hyperplasia, Limbal dermoid, Polycystic ovar... | ORPHA:2969 | |
Isolated Anencephaly | Thymus hyperplasia | ORPHA:563609 | |
Cataract 5, Multiple Types | Anterior polar cataract, Zonular cataract, Lamellar cataract, Nuclear cataract, Pulverulent cataract | OMIM:116800 | |
Myopathy, Epilepsy, And Progressive Cerebral Atrophy | Thymus hyperplasia | OMIM:619036 | |
Proteus Syndrome | Ovarian neoplasm, Buphthalmos, Testicular neoplasm, Enlarged polycystic ovaries, Cataract, Spleno... | ORPHA:744 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Asb16tm94(L1L2_gt1) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Asb16em1(IMPC)Ccpcz | Inter-exon deletion | Mice |
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