Gene: Tardbp

Order

Name TAR DNA binding protein

Synonyms
  • 1190002A23Rik
  • Tdp43
  • TDP-43

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2387629    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Tardbp

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Tardbp data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Tardbptm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased mean platelet volume Tardbptm1b(EUCOMM)Wtsi HET Female postnatal 1.74E-28
increased mean platelet volume Tardbptm1b(EUCOMM)Wtsi HET Male postnatal 1.74E-28
absent startle reflex Tardbptm1b(EUCOMM)Wtsi HET Male postnatal 6.92E-9
decreased basophil cell number Tardbptm1b(EUCOMM)Wtsi HET Female postnatal 2.02E-6
increased lymphocyte cell number Tardbptm1b(EUCOMM)Wtsi HET Female Male postnatal 6.09E-6
decreased neutrophil cell number Tardbptm1b(EUCOMM)Wtsi HET Female Male postnatal 1.09E-5
increased fasted circulating glucose level Tardbptm1b(EUCOMM)Wtsi HET Female postnatal 1.77E-5
decreased blood urea nitrogen level Tardbptm1b(EUCOMM)Wtsi HET Female postnatal 8.36E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Bone 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cerebellum 2 No
Cerebral cortex 2 No
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Heart 2 No
Hippocampus 2 No
Hypothalamus 2 No
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No
Oral epithelium 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No
Pancreas 2 No (5/584)
Parathyroid gland 2 No
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584)
Stomach 2 No (12/584)
Striatum 2 No
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No
Uterus 2 No
Vascular system 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    reproductive system
    integumental system
    trunk
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485)
Ear 2 (1/485)
Embryo 2 (1/485)
Eye 2 (1/485)
Foot 2 (1/485)
Forebrain 2 (1/485)
Forelimb 2 (1/485)
Hand 2 (1/485)
Head 2 (5/485)
Heart 2 (1/485)
Hindbrain 2 (6/485)
Hindlimb 2 (1/485)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Tail 2 (1/485)
Tail somite 2 (1/485)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • Adult LacZ: LacZ Images Wholemount
    5 Images
  • Embryo LacZ: LacZ images wholemount
    4 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Tardbptm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Tardbptm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Tardbptm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette)
Vector
Gene