Gene: Aph1a

Name aph1 homolog A, gamma secretase subunit

Synonyms 6530402N02Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2385110   Ensembl Gene   Ensembl Orthologs

Phenotype associations for Aph1a

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Aph1a data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Aph1atm1b(KOMP)Mbp HET Female embryonic day 18.5 0.0
abnormal embryo size Aph1atm1b(KOMP)Mbp HOM Male embryonic day 18.5 0.0
abnormal embryo size Aph1atm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
abnormal embryo size Aph1atm1b(KOMP)Mbp HET Female embryonic day 9.5 0.0
embryonic lethality prior to tooth bud stage Aph1atm1b(KOMP)Mbp HOM Female Male embryonic day 12.5 0.0
pale yolk sac Aph1atm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
pallor Aph1atm1b(KOMP)Mbp HOM Female Male embryonic day 9.5 0.0
unresponsive to tactile stimuli Aph1atm1b(KOMP)Mbp HOM Male embryonic day 18.5 0.0
unresponsive to tactile stimuli Aph1atm1b(KOMP)Mbp HET Female Male embryonic day 18.5 0.0
abnormal bone structure Aph1atm1b(KOMP)Mbp HET Male postnatal 6.37E-9
increased bone mineral content Aph1atm1b(KOMP)Mbp HET Male postnatal 1.15E-6
increased or absent threshold for auditory brainstem response Aph1atm1b(KOMP)Mbp HET Male postnatal 9.69E-6
decreased total body fat amount Aph1atm1b(KOMP)Mbp HET Male postnatal 2.69E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No (2/2)
Cartilage tissue 2 No (1/562) (2/2)
Cecum 2 No (1/355)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393) (2/2)
Eye 2 No (1/562)
Gall bladder 2 No (2/2)
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No (2/2)
Lower urinary tract 2 No (3/562) (2/2)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562) (2/2)
Mammary gland 2 No (1/2)
Mesenteric lymph node 2 No (2/2)
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562) (2/2)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393) (2/2)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No (2/2)
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No (2/2)
Uterus 2 No (2/562) (1/2)
Vas deferens 2 No (1/360) (1/2)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 2 No (2/2)
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system digestive system cardiovascular system set of connective tissues
    reproductive system
    musculoskeletal system adipose tissue
    trunk
    postnatal mouse
    nervous system
    immune system
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    11 Images
  • X-ray: XRay Images Forepaw
    11 Images
  • X-ray: XRay Images Skull Lateral Orientation
    11 Images
  • X-ray: XRay Images Lateral Orientation
    11 Images
  • Adult LacZ: LacZ Images Wholemount
    8 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    11 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Aph1atm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Aph1atm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre)
Vector
Gene