Gene: Spns2

Phenotype associations for Spns2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Spns2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
absent pinna reflex Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 5.54E-30
abnormal eye pigmentation Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 4.04E-25
corneal opacity Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.34E-21
corneal vascularization Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 4.21E-21
decreased leukocyte cell number Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 9.25E-21
abnormal cornea morphology Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.24E-20
decreased leukocyte cell number Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.15E-13
corneal opacity Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.05E-11
corneal vascularization Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.05E-11
abnormal cornea morphology Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 9.77E-11
absent pinna reflex Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 9.77E-11
abnormal eye morphology Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 6.79E-9
narrow eye opening Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 8.6E-9
trunk curl Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 8.6E-9
abnormal eye size Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 3.31E-8
increased mean corpuscular volume Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 2.15E-6
excessive tearing Spns2tm1a(KOMP)Wtsi HOM Female postnatal 5.58E-6
abnormal iris morphology Spns2tm1a(KOMP)Wtsi HOM Male postnatal 6.88E-6
abnormal eyelid aperture Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 7.24E-6
increased bone mineral density Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.0E-5
abnormal rib morphology Spns2tm1a(KOMP)Wtsi HOM Female postnatal 3.83E-5
abnormal behavior Spns2tm1a(KOMP)Wtsi HOM Female Male postnatal 5.13E-5
increased circulating sodium level Spns2tm1b(KOMP)Wtsi HOM Female Male postnatal 5.58E-5
abnormal iris morphology Spns2tm1b(KOMP)Wtsi HOM Female postnatal 9.7E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 11 No (2/176)
Aorta 11 No (2/530)
Blood vessel 11 No
Bone 11 No (1/515) (12/12)
Brain 11 No (8/530) (12/12)
Brainstem 11 No (5/530)
Brown adipose tissue 11 No
Cartilage tissue 11 No (1/530)
Cerebellum 11 No (6/530)
Cerebral cortex 11 No (6/530)
Eye 11 No (1/530) (10/12)
Gall bladder 11 No (1/12)
Heart 11 No (4/530)
Hippocampus 11 No (7/530)
Hypothalamus 11 No (5/529)
Kidney 11 No (13/530) (12/12)
Large intestine 11 No (7/530) (1/12)
Liver 11 No (11/12)
Lower urinary tract 11 No (3/530) (11/12)
Lung 11 No (4/530) (6/12)
Lymph node 11 No (2/530) (12/12)
Mammary gland 11 No (4/12)
Esophagus 11 No (12/12)
Olfactory lobe 11 No (2/176)
Ovary 11 No (1/530) (3/12)
Oviduct 11 No (1/530) (5/12)
Pancreas 11 No (2/530) (6/12)
Parathyroid gland 11 No (2/516)
Peripheral nervous system 11 No (4/530) (7/12)
Peyer's patch 11 No (1/176) (10/12)
Pituitary gland 11 No (2/530)
Prostate gland 11 No (3/530)
Skeletal muscle tissue 11 No
Skin 11 No (2/530) (12/12)
Small intestine 11 No (5/530) (2/12)
Spinal cord 11 No (5/530) (12/12)
Spleen 11 No (3/530) (7/12)
Stomach 11 No (5/530) (12/12)
Striatum 11 No (6/530)
Testis 11 No (7/530) (6/12)
Thymus 11 No (1/530) (3/12)
Thyroid gland 11 No (11/530) (2/12)
Trachea 11 No (5/530) (2/12)
Uterus 11 No (1/530) (3/12)
White adipose tissue 11 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system endocrine system digestive system reproductive system musculoskeletal system trunk postnatal mouse nervous system sensory organ immune system exocrine system integumental system urinary system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Secondary lacZ Expression Data
trunk (27)
  • Spns2tm1b(KOMP)Wtsi
    THYMUS, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    OVIDUCT, OVARY, UTERUS, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI

show all 27 images

digestive system (8)
  • Spns2tm1b(KOMP)Wtsi
    LARGE INTESTINE, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    LIVER, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    ESOPHAGUS, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    LIVER, HET, Female, WTSI

show all 8 images

immune system (8)
  • Spns2tm1b(KOMP)Wtsi
    THYMUS, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    PEYER'S PATCH, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    LYMPH NODE, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    SPLEEN, HET, Male, WTSI
  • Spns2tm1a(KOMP)Wtsi
    LYMPH NODE, HET, Female, WTSI

show all 8 images

nervous system (8)
  • Spns2tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    BRAIN, HET, Female, WTSI

show all 8 images

reproductive system (6)
  • Spns2tm1b(KOMP)Wtsi
    OVIDUCT, OVARY, UTERUS, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    PROSTATE GLAND, HET, Male, WTSI
  • Spns2tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Spns2tm1a(KOMP)Wtsi
    OVIDUCT, HET, Female, WTSI

show all 6 images

urinary system (6)
  • Spns2tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Male, WTSI
  • Spns2tm1a(KOMP)Wtsi
    KIDNEY, HET, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    URINARY BLADDER, LOWER URINARY TRACT, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    KIDNEY, HET, Male, WTSI

show all 6 images

integumental system (3)
  • Spns2tm1a(KOMP)Wtsi
    SKIN, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    MAMMARY GLAND, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    SKIN, HET, Female, WTSI
musculoskeletal system (3)
  • Spns2tm1a(KOMP)Wtsi
    BONE, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    BONE, HET, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    BONE, PERIPHERAL NERVOUS SYSTEM, HET, Female, WTSI
sensory organ (3)
  • Spns2tm1a(KOMP)Wtsi
    EYE, RETINA, HET, Male, WTSI
  • Spns2tm1a(KOMP)Wtsi
    EYE, HET, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    EYE, HET, Female, WTSI
exocrine system (2)
  • Spns2tm1b(KOMP)Wtsi
    PROSTATE GLAND, HET, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    MAMMARY GLAND, HET, Female, WTSI
endocrine system (1)
  • Spns2tm1b(KOMP)Wtsi
    THYROID GLAND, HET, Male, WTSI
respiratory system (1)
  • Spns2tm1b(KOMP)Wtsi
    LUNG, HET, Female, WTSI

Associated Images

Associated Images
  • Brain Histopathology: Hippocampal section
    3 Images
  • Brain Histopathology: Striatal Section
    2 Images
  • X-ray: XRay Images Dorso Ventral
    39 Images
  • X-ray: XRay Images Lateral Orientation
    23 Images
  • Eye Morphology: Images Slit Lamp
    24 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    13 Images
  • X-ray: XRay Images Skull Lateral Orientation
    12 Images
  • X-ray: XRay Images Forepaw
    11 Images
Legacy Phenotype Associated Images
Xray (207)
  • Spns2tm1a(KOMP)Wtsi
    WT, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    TRUNK, WT, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    HEAD, WT, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    LOWER ARM, WT, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    TRUNK, HOM, Female, WTSI

show all 207 images

Eye Morphology (58)
  • Spns2tm1a(KOMP)Wtsi
    EYE, corneal vascularization, corneal opacity, HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    EYE, corneal ulcer, corneal opacity, corneal vascularization, HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    EYE, corneal vascularization, corneal opacity, HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    EYE, corneal opacity, cornea/lens fusion, corneal vascularization, HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    EYE, corneal opacity, HOM, Female, WTSI

show all 58 images

Flow Cytometry (12)
  • Spns2tm1b(KOMP)Wtsi
    increased NK cell number, decreased T cell number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    increased NK cell number, decreased T cell number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    decreased B cell number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    decreased B cell number, HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    decreased CD4-positive T cell number, HOM, Female, WTSI

show all 12 images

Dysmorphology (8)
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Female, WTSI

show all 8 images

Brain Histopathology (6)
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    decreased corpus callosum size, CORPUS CALLOSUM, HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    CORPUS CALLOSUM, decreased corpus callosum size, HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Male, WTSI

show all 6 images

Skin Histopathology (5)
  • Spns2tm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Spns2tm1a(KOMP)Wtsi
    HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Female, WTSI
  • Spns2tm1b(KOMP)Wtsi
    HOM, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Spns2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Spns2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene