Gene: Nae1

Order

Name NEDD8 activating enzyme E1 subunit 1

Synonyms Appbp1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2384561    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Nae1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nae1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, complete penetrance Nae1tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
thrombocytopenia Nae1tm1b(EUCOMM)Wtsi HET Female Male postnatal 8.82E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
No expression data was found for this adult tab
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (6/482) (1/1)
Ear 1 (1/482) (1/1)
Embryo 1 (1/482) (1/1)
Eye 1 (1/482) (1/1)
Foot 1 (1/482) (1/1)
Forebrain 1 (1/482) (1/1)
Forelimb 1 (1/482) (1/1)
Hand 1 (1/482) (1/1)
Head 1 (5/482) (1/1)
Heart 1 (1/482) (1/1)
Hindbrain 1 (6/482) (1/1)
Hindlimb 1 (1/482) (1/1)
Liver 1 (1/482) (1/1)
Lung 1 (1/482) (1/1)
Mandibular process 1 (1/482) (1/1)
Maxillary process 1 (1/482) (1/1)
Midbrain 1 (1/482) (1/1)
Oral cavity 1 (1/482) (1/1)
Skin 1 (1/482) (1/1)
Tail 1 (1/482) (1/1)
Tail somite 1 (1/482) (1/1)


Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Embryo LacZ: LacZ images wholemount
    1 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Nae1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nae1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene