Gene: Rspo1

Order

Name R-spondin 1

Synonyms
  • R-spondin
  • Rspondin

Status ES CellsMice
tm2a
Mice
tm2b
Mice
tm1
Mice
tm1.1
phenotype data available

Links MGI:2183426    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Rspo1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Rspo1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal kidney morphology Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 0.0
abnormal seminal vesicle morphology Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 0.0
abnormal testis morphology Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 0.0
female infertility Rspo1tm1.1(KOMP)Vlcg HOM Female postpartum stage 0.0
small testis Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 0.0
abnormal eye anterior chamber depth Rspo1tm2b(KOMP)Wtsi HOM Female Male postnatal 1.56E-17
abnormal vitreous body morphology Rspo1tm2b(KOMP)Wtsi HOM Female Male postnatal 1.2E-13
decreased circulating insulin level Rspo1tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.68E-11
decreased total body fat amount Rspo1tm1.1(KOMP)Vlcg HOM Female Male postnatal 3.23E-10
decreased total retina thickness Rspo1tm2b(KOMP)Wtsi HOM Female Male postnatal 1.31E-9
increased lean body mass Rspo1tm1.1(KOMP)Vlcg HOM Female Male postnatal 6.17E-8
abnormal retinal outer nuclear layer morphology Rspo1tm2b(KOMP)Wtsi HOM Female Male postnatal 6.2E-7
decreased circulating total protein level Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 2.07E-6
decreased circulating serum albumin level Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 4.91E-6
decreased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Male postnatal 7.97E-6
increased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Female postnatal 7.97E-6
abnormal vibrissa morphology Rspo1tm1.1(KOMP)Vlcg HOM Female postnatal 1.14E-5
decreased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Male postnatal 5.74E-5
increased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Female postnatal 5.74E-5
decreased circulating cholesterol level Rspo1tm1.1(KOMP)Vlcg HOM Male postnatal 8.31E-5
increased grip strength Rspo1tm1.1(KOMP)Vlcg HOM Female Male postnatal 9.73E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415)
Aorta 2 No
Blood 2 No
Bone marrow 2 No
Brain 2 No
Brainstem 2 No
Brown adipose tissue 2 No
Cartilage tissue 2 No
Cecum 2 No (12/383)
Cerebellum 2 No
Cerebral cortex 2 No
Chest bone 2 No
Colon 2 No (12/127)
Diaphragm 2 No (1/2)
Duodenum 2 No (2/127)
Epididymis 2 No (18/134) (1/2)
Esophagus 2 No (7/415)
Eye 2 No
Gall bladder 2 No
Gonadal fat pad 2 No
Harderian gland 2 No
Heart 2 No
Hindlimb 2 No
Hippocampus 2 No
Hypothalamus 2 No
Ileum 2 No (14/127) (1/2)
Jejunum 2 No (6/127) (1/2)
Kidney 2 No (18/584)
Large intestine 2 No (10/584)
Liver 2 No
Lower urinary tract 2 No
Lung 2 No (1/2)
Lymph node 2 No
Mammary gland 2 No
Mesenteric lymph node 2 No
Mesenteric adipose tissue 2 No (1/2)
Midbrain 2 No
Olfactory lobe 2 No
Ovary 2 No (1/584)
Oviduct 2 No
Pancreas 2 No (5/584) (1/2)
Parathyroid gland 2 No
Parotid gland 2 No
Penis 2 No (1/2)
Peripheral nervous system 2 No
Peyer's patch 2 No
Pituitary gland 2 No
Prostate gland 2 No (12/584) (1/2)
Quadriceps 2 No
Sciatic nerve 2 No
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584)
Spinal cord 2 No
Spleen 2 No (2/584) (1/2)
Stomach 2 No (12/584) (1/2)
Stomach pyloric region 2 No
Striatum 2 No
Sublingual gland 2 No
Submandibular gland 2 No (2/132)
Testis 2 No (2/584)
Thymus 2 No
Thyroid gland 2 No (15/584) (1/2)
Tongue 2 No (5/127) (2/2)
Trachea 2 No (1/2)
Trigeminal V nerve 2 No
Urinary bladder 2 No
Uterus 2 No
Vagina 2 No
Vas deferens 2 No (15/388) (1/2)
Vascular system 2 No
Vesicular gland 2 No
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    respiratory system endocrine system digestive system set of connective tissues reproductive system adipose tissue musculoskeletal system trunk postnatal mouse sensory organ immune system exocrine system integumental system
No expression image was found for this adult tab
No expression data was found for this embryo tab


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Rspo1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Rspo1tm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Rspo1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette)
Vector
Gene
Rspo1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette)
Vector
Gene
Fixed Tissue