Gene: Dicer1

Order

Name dicer 1, ribonuclease type III

Synonyms
  • Dicer1
  • D12Ertd7e
  • 1110006F08Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2177178    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Dicer1

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Dicer1 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to organogenesis Dicer1tm1b(EUCOMM)Wtsi HOM Female Male embryonic day 9.5 0.0
preweaning lethality, complete penetrance Dicer1tm1b(EUCOMM)Wtsi HOM Female Male n/a 0.0
decreased red blood cell distribution width Dicer1tm1b(EUCOMM)Wtsi HET Female Male postnatal 1.68E-8
decreased spleen weight Dicer1tm1b(EUCOMM)Wtsi HET Female Male postnatal 4.75E-7
decreased neutrophil cell number Dicer1tm1b(EUCOMM)Wtsi HET Female Male postnatal 1.11E-6

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone 2 No
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No (2/2)
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584) (2/2)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (2/2)
Ear 2 (1/485) (1/2)
Embryo 2 (1/485) (2/2)
Eye 2 (1/485) (2/2)
Foot 2 (1/485) (1/2)
Forebrain 2 (1/485) (2/2)
Forelimb 2 (1/485) (2/2)
Hand 2 (1/485) (1/2)
Head 2 (5/485) (2/2)
Heart 2 (1/485) (1/2)
Hindbrain 2 (6/485) (2/2)
Hindlimb 2 (1/485) (2/2)
Liver 2 (1/485) (1/2)
Lung 2 (1/485) (1/2)
Mandibular process 2 (1/485) (1/2)
Maxillary process 2 (1/485) (1/2)
Midbrain 2 (1/485) (2/2)
Oral cavity 2 (1/485) (1/2)
Skin 2 (1/485) (1/2)
Tail 2 (1/485) (2/2)
Tail somite 2 (1/485) (1/2)


Associated Images

Associated Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    9 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Adult LacZ: LacZ Images Wholemount
    22 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Dicer1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Dicer1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Dicer1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene