Gene: Scrib

Order

Name scribbled planar cell polarity

Synonyms
  • Crc
  • Scrb1

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2145950    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Scrib

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Scrib data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal craniofacial morphology Scribtm1b(NCOM)Mfgc HOM Female embryonic day 12.5 0.0
abnormal craniofacial morphology Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM Female embryonic day 12.5 0.0
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 15.5 0.0
abnormal embryo size Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 9.5 0.0
abnormal eye morphology Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 12.5 0.0
abnormal hindbrain morphology Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 12.5 0.0
abnormal midbrain morphology Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 12.5 0.0
abnormal neural tube closure Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 12.5 0.0
abnormal neural tube closure Scribtm1b(NCOM)Mfgc HOM Male embryonic day 9.5 0.0
abnormal pericardium morphology Scribtm1b(NCOM)Mfgc HOM Female embryonic day 12.5 0.0
abnormal placenta size Scribtm1b(NCOM)Mfgc HOM Female embryonic day 12.5 0.0
embryonic growth retardation Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 9.5 0.0
pale yolk sac Scribtm1b(NCOM)Mfgc HOM Female embryonic day 12.5 0.0
prenatal lethality prior to heart atrial septation Scribtm1b(NCOM)Mfgc HOM Female Male embryonic day 14.5 0.0
preweaning lethality, complete penetrance Scribtm1b(NCOM)Mfgc HOM Female Male n/a 0.0
decreased lean body mass Scribtm1b(NCOM)Mfgc HET Female Male postnatal 6.21E-5
short tibia Scribtm1b(NCOM)Mfgc HET Female Male postnatal 7.15E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
No expression data was found for this adult tab
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2 (1/51) (2/2)
Brain 2 (6/485) (2/3)
Central nervous system ganglion 2 (1/51) (2/2)
Ear 2 (1/485) (2/3)
Embryo 2 (1/485) (2/3)
Eye 2 (1/485) (2/3)
Foot 2 (1/485) (2/3)
Forebrain 2 (1/485) (2/3)
Forelimb 2 (1/485) (2/3)
Gut 2 (1/50) (2/2)
Hand 2 (1/485) (2/3)
Head 2 (5/485) (2/3)
Heart 2 (1/485) (2/3)
Hindbrain 2 (6/485) (2/3)
Hindlimb 2 (1/485) (2/3)
Liver 2 (1/485) (2/3)
Lung 2 (1/485) (2/3)
Mandibular process 2 (1/485) (2/3)
Maxillary process 2 (1/485) (2/3)
Midbrain 2 (1/485) (2/3)
Nose 2 (1/51) (2/2)
Oral cavity 2 (1/485) (2/3)
Skeleton 2 (1/51) (2/2)
Skin 2 (1/485) (2/3)
Spinal cord 2 (1/50) (2/2)
Tail 2 (1/485) (2/3)
Tail somite 2 (1/485) (2/3)
Trachea 2 (1/50) (2/2)
Urinary system 2 (1/50) (2/2)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    10 Images
  • Combined SHIRPA and Dysmorphology
    1 Images
  • X-ray: XRay Images Lateral Orientation
    10 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    10 Images
  • X-ray: XRay Images Skull Lateral Orientation
    10 Images
  • Gross Pathology and Tissue Collection
    8 Images
  • Eye Morphology: Images Ophthalmoscopy
    13 Images
  • Histopathology
    3 Images
  • Gross Morphology Embryo E14.5-E15.5
    4 Images
  • Gross Morphology Embryo E9.5
    6 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Scribtm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Scribtm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Scribtm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene