Gene: Trib2

Name tribbles pseudokinase 2

Synonyms TRB2

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2145021   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Trib2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Trib2 data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
abnormal embryo size Trib2tm1b(KOMP)Wtsi HOM Female embryonic day 18.5 0.0
abnormal limb morphology Trib2tm1b(KOMP)Wtsi HOM Female embryonic day 18.5 0.0
preweaning lethality, incomplete penetrance Trib2tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
unresponsive to tactile stimuli Trib2tm1b(KOMP)Wtsi HOM Female Male embryonic day 18.5 0.0
unresponsive to tactile stimuli Trib2tm1b(KOMP)Wtsi HET Female Male embryonic day 18.5 0.0
cardiovascular system phenotype Trib2tm1b(KOMP)Wtsi HET Female postnatal 6.4E-6
decreased heart rate variability Trib2tm1b(KOMP)Wtsi HET Female postnatal 1.88E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (5/393) (2/2)
Aorta 2 No (1/562) (2/2)
Bone 2 No (1/539) (2/2)
Brain 2 No (6/562) (2/2)
Brainstem 2 No (4/562) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/562) (2/2)
Cecum 2 No (1/355) (2/2)
Cerebellum 2 No (4/562) (2/2)
Cerebral cortex 2 No (5/562) (2/2)
Esophagus 2 No (2/393)
Eye 2 No (1/562)
Gall bladder 2 No
Heart 2 No (3/562) (2/2)
Hippocampus 2 No (5/562) (2/2)
Hypothalamus 2 No (4/562) (2/2)
Kidney 2 No (20/562) (2/2)
Large intestine 2 No (12/562) (2/2)
Liver 2 No
Lower urinary tract 2 No (3/562)
Lung 2 No (3/562) (2/2)
Lymph node 2 No (1/562)
Mammary gland 2 No
Mesenteric lymph node 2 No
Olfactory lobe 2 No (4/393) (2/2)
Oral epithelium 2 No
Ovary 2 No (1/562) (1/2)
Oviduct 2 No (2/562) (1/2)
Pancreas 2 No (6/562)
Parathyroid gland 2 No (2/540) (2/2)
Peripheral nervous system 2 No (3/562) (2/2)
Peyer's patch 2 No (1/393)
Pituitary gland 2 No (1/562)
Prostate gland 2 No (5/562) (1/2)
Skeletal muscle 2 No (2/2)
Skin 2 No (1/562) (2/2)
Small intestine 2 No (11/562) (2/2)
Spinal cord 2 No (3/562) (2/2)
Spleen 2 No (4/562) (2/2)
Stomach 2 No (9/562) (2/2)
Striatum 2 No (4/562) (2/2)
Testis 2 No (4/562) (1/2)
Thymus 2 No
Thyroid gland 2 No (16/562) (2/2)
Trachea 2 No (3/562) (2/2)
Trigeminal V nerve 2 No (2/2)
Urinary bladder 2 No
Uterus 2 No (2/562) (1/2)
Vas deferens 2 No (1/360)
Vascular system 2 No (1/393) (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system respiratory system digestive system cardiovascular system set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    immune system exocrine system integumental system urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2 (1/3) (2/2)
Axial skeleton 2 (1/5) (2/2)
Brain 2 (6/440) (2/2)
Central nervous system ganglion 2 (1/5) (2/2)
Cranium 2 Image Only (2/2)
Dorsal root ganglion 2 (1/3) (2/2)
Ear 2 (1/440) (2/2)
Embryo 2 (1/440) (2/2)
Outer ear 2 (2/2)
Eye 2 (1/440) (2/2)
Femur pre-cartilage condensation 2 Image Only (2/2)
Foot 2 (2/2)
Forearm 2 (2/2)
Forebrain 2 (1/440) (2/2)
Forelimb 2 (1/440) (2/2)
Fronto-nasal process 2 (1/4) (2/2)
Gut 2 (1/4) (2/2)
Hand 2 (2/2)
Head 2 (5/440) (2/2)
Head mesenchyme 2 (1/3) (2/2)
Heart 2 (1/440) (2/2)
Heart ventricle 2 (1/3) (2/2)
Hindbrain 2 (5/440) (2/2)
Hindlimb 2 (1/440) (2/2)
Humerus pre-cartilage condensation 2 Image Only (2/2)
Inner ear 2 Image Only (2/2)
Intestine 2 (2/2)
Liver 2 (1/440) (2/2)
Lower leg 2 (2/2)
Lung 2 (1/440) (2/2)
Mandibular process 2 (1/440) (2/2)
Maxillary process 2 (1/440) (2/2)
Mesonephros of female 2 Image Only (1/2)
Mesonephros of male 2 Image Only (1/2)
Metanephros 2 Image Only (2/2)
Midbrain 2 (1/440) (2/2)
Nasal septum 2 (2/2)
Nose 2 (1/5) (2/2)
Notochord 2 (2/2)
Oral cavity 2 (1/440) (2/2)
Outflow tract 2 (1/3) (2/2)
Pancreas 2 Image Only (2/2)
Pericardium 2 (1/2) (2/2)
Pharynx 2 Image Only (2/2)
Radius-ulna pre-cartilage condensation 2 Image Only (2/2)
Rib pre-cartilage condensation 2 (1/2) (2/2)
Skeleton 2 (1/5) (2/2)
Skin 2 (1/440) (2/2)
Spinal cord 2 (1/4) (2/2)
Stomach 2 Image Only (2/2)
Tail 2 (1/440) (2/2)
Tail somite 2 (1/440) (2/2)
Thoracic vertebral cartilage condensation 2 (1/2) (2/2)
Tongue 2 Image Only (2/2)
Trachea 2 Image Only (2/2)
Trunk mesenchyme 2 (1/3) (2/2)
Umbilical artery embryonic part 2 (2/2)
Umbilical vein embryonic part 2 (2/2)
Upper arm 2 (2/2)
Upper leg 2 (2/2)
Urinary system 2 Image Only (2/2)
Vibrissa 2 (2/2)


Associated Images

Associated Images
  • Adult LacZ: LacZ Images Wholemount
    2 Images

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Trib2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Trib2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene
Trib2tm45705(pL1L2_frt_BetactP_neo_frt_lox)
Vector
Gene