Gene: Usp22

Order

Name ubiquitin specific peptidase 22

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:2144157    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Lethal

Phenotype associations for Usp22

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Usp22 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
embryonic lethality prior to tooth bud stage Usp22tm1b(KOMP)Wtsi HOM Female Male embryonic day 12.5 0.0
preweaning lethality, complete penetrance Usp22tm1b(KOMP)Wtsi HOM Female Male n/a 0.0
preweaning lethality, complete penetrance Usp22tm1a(KOMP)Wtsi HOM Female Male n/a 0.0
abnormal gait Usp22tm1b(KOMP)Wtsi HET Male postnatal 8.88E-7
decreased mean platelet volume Usp22tm1b(KOMP)Wtsi HET Female postnatal 4.02E-5
decreased lean body mass Usp22tm1b(KOMP)Wtsi HET Male postnatal 4.24E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/415) (2/2)
Aorta 2 No (2/2)
Bone 2 No (2/2)
Brain 2 No (2/2)
Brainstem 2 No (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (2/2)
Cerebellum 2 No (2/2)
Cerebral cortex 2 No (2/2)
Esophagus 2 No (7/415) (2/2)
Eye 2 No (2/2)
Gall bladder 2 No (2/2)
Heart 2 No (2/2)
Hippocampus 2 No (2/2)
Hypothalamus 2 No (2/2)
Kidney 2 No (18/584) (2/2)
Large intestine 2 No (10/584) (2/2)
Liver 2 No
Lower urinary tract 2 No (2/2)
Lung 2 No
Lymph node 2 No
Mammary gland 2 No
Olfactory lobe 2 No (2/2)
Oral epithelium 2 No (1/2)
Ovary 2 No (1/584) (1/2)
Oviduct 2 No (1/2)
Pancreas 2 No (5/584) (2/2)
Parathyroid gland 2 No (2/2)
Peripheral nervous system 2 No (2/2)
Peyer's patch 2 No
Pituitary gland 2 No (2/2)
Prostate gland 2 No (12/584) (1/2)
Skeletal muscle 2 No
Skin 2 No (2/2)
Small intestine 2 No (9/584) (2/2)
Spinal cord 2 No (2/2)
Spleen 2 No (2/584)
Stomach 2 No (12/584) (2/2)
Striatum 2 No (2/2)
Testis 2 No (2/584) (1/2)
Thymus 2 No
Thyroid gland 2 No (15/584)
Trachea 2 No (2/2)
Uterus 2 No (1/2)
Vascular system 2 No (2/2)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    endocrine system
    respiratory system
    digestive system
    cardiovascular system
    set of connective tissues
    reproductive system
    musculoskeletal system
    trunk
    postnatal mouse
    nervous system
    sensory organ
    exocrine system
    integumental system
    urinary system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2 (6/485) (3/3)
Ear 2 (1/485)
Embryo 2 (1/485) (3/3)
Eye 2 (1/485) (3/3)
Foot 2 (1/485) Image Only
Forebrain 2 (1/485) (3/3)
Forelimb 2 (1/485) (3/3)
Hand 2 (1/485) Image Only
Head 2 (5/485) (3/3)
Heart 2 (1/485) Image Only
Hindbrain 2 (6/485) (3/3)
Hindlimb 2 (1/485) (3/3)
Liver 2 (1/485)
Lung 2 (1/485)
Mandibular process 2 (1/485)
Maxillary process 2 (1/485)
Midbrain 2 (1/485) (3/3)
Oral cavity 2 (1/485)
Skin 2 (1/485)
Tail 2 (1/485) (3/3)
Tail somite 2 (1/485) (3/3)


Associated Images

Associated Images
  • X-ray: XRay Images Dorso Ventral
    51 Images
  • Adult LacZ: LacZ Images Wholemount
    22 Images
  • Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
    4 Images
  • Echo: M-Mode Images
    32 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    24 Images
  • X-ray: XRay Images Lateral Orientation
    38 Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
  • X-ray: XRay Images Forepaw
    13 Images
Legacy Phenotype Associated Images
Xray (84)
  • Usp22tm1a(KOMP)Wtsi
    HET, Female, WTSI
  • Usp22tm1a(KOMP)Wtsi
    HET, Female, WTSI
  • Usp22tm1a(KOMP)Wtsi
    HET, Female, WTSI
  • Usp22tm1a(KOMP)Wtsi
    HET, Female, WTSI
  • Usp22tm1a(KOMP)Wtsi
    HET, Female, WTSI

show all 84 images

Eye Morphology (2)
  • Usp22tm1a(KOMP)Wtsi
    right eye, WT, Male, WTSI
  • Usp22tm1a(KOMP)Wtsi
    left eye, WT, Male, WTSI
Skin Histopathology (2)
  • Usp22tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI
  • Usp22tm1a(KOMP)Wtsi
    back skin, HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Usp22tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Usp22tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene