Gene: Nedd4l

Name neural precursor cell expressed, developmentally down-regulated gene 4-like

Synonyms
  • Nedd4b
  • Nedd4-2
  • 1300012C07Rik

Status ES CellsMice
tm1a
Mice
tm1b
phenotype data available

Links MGI:1933754   Ensembl Gene   Ensembl Orthologs

Viability Homozygous - Subviable

Phenotype associations for Nedd4l

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Nedd4l data for that phenotype.

Embryo Data: 3D Embryo Imaging
Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
preweaning lethality, incomplete penetrance Nedd4ltm1b(KOMP)Wtsi HOM Female Male n/a 0.0
decreased prepulse inhibition Nedd4ltm1b(KOMP)Wtsi HOM Female Male postnatal 2.68E-13
absent startle reflex Nedd4ltm1b(KOMP)Wtsi HOM Male postnatal 4.7E-12
decreased startle reflex Nedd4ltm1b(KOMP)Wtsi HOM Female Male postnatal 1.75E-11
abnormal retina morphology Nedd4ltm1b(KOMP)Wtsi HOM Male postnatal 3.11E-10
increased or absent threshold for auditory brainstem response Nedd4ltm1b(KOMP)Wtsi HOM Female Male postnatal 1.0E-7
hypoactivity Nedd4ltm1b(KOMP)Wtsi HOM Female Male postnatal 3.36E-5
abnormal behavior Nedd4ltm1b(KOMP)Wtsi HOM Female Male postnatal 6.17E-5

Download data as: TSV XLS



Expression

IMPC lacZ Expression Data
Show expression table

 Expression    No Expression    No Tissue Available    Ambiguous  

Show Wildtype Expression
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No (2/354)
Aorta 2 No (2/530)
Bone 2 No (1/515)
Brain 2 No (8/530) (2/2)
Brainstem 2 No (5/530) (2/2)
Brown adipose tissue 2 No
Cartilage tissue 2 No (1/530)
Cerebellum 2 No (6/530)
Cerebral cortex 2 No (6/530)
Esophagus 2 No (1/354)
Eye 2 No (1/530)
Gall bladder 2 No
Heart 2 No (4/530)
Hippocampus 2 No (7/530) (2/2)
Hypothalamus 2 No (5/529)
Kidney 2 No (13/530)
Large intestine 2 No (7/530)
Liver 2 No
Lower urinary tract 2 No (3/530)
Lung 2 No (4/530)
Lymph node 2 No (2/530)
Mammary gland 2 No
Olfactory lobe 2 No (3/354)
Oral epithelium 2 No
Ovary 2 No (1/530)
Oviduct 2 No (1/530)
Pancreas 2 No (2/530)
Parathyroid gland 2 No (2/516)
Peripheral nervous system 2 No (4/530)
Peyer's patch 2 No (1/354)
Pituitary gland 2 No (2/530)
Prostate gland 2 No (3/530)
Skeletal muscle 2 No
Skin 2 No (2/530)
Small intestine 2 No (5/530)
Spinal cord 2 No (5/530)
Spleen 2 No (3/530)
Stomach 2 No (5/530)
Striatum 2 No (6/530)
Testis 2 No (7/530)
Thymus 2 No (1/530)
Thyroid gland 2 No (11/530)
Trachea 2 No (5/530)
Uterus 2 No (1/530)
Vascular system 2 No (1/354)
White adipose tissue 2 No
Expression in Anatomogram

Tissues/organs lacZ+ expression

    postnatal mouse
    nervous system
No expression image was found for this adult tab

 Expression    No Expression    No Tissue Available    Ambiguous  

Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1 (5/413)
Ear 1
Embryo 1
Eye 1
Foot 1
Forebrain 1
Forelimb 1
Hand 1
Head 1 (4/413)
Heart 1
Hindbrain 1 (5/413)
Hindlimb 1
Liver 1
Lung 1
Mandibular process 1
Maxillary process 1
Midbrain 1
Oral cavity 1
Skin 1
Tail 1
Tail somite 1


Associated Images

Associated Images
  • Embryo LacZ: LacZ images wholemount
    8 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    16 Images
  • X-ray: XRay Images Lateral Orientation
    16 Images
  • Echo: M-Mode Images
    36 Images
  • X-ray: XRay Images Dorso Ventral
    16 Images
  • Adult LacZ: LacZ Images Wholemount
    3 Images

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse
Nedd4ltm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene
Nedd4ltm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre)
Vector
Gene