Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Txn2 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Combined Oxidative Phosphorylation Deficiency 29 | OMIM:616811 | ||
Combined Oxidative Phosphorylation Defect Type 29 | ORPHA:478029 |
The table below shows human diseases predicted to be associated to Txn2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10 | Neural tube defect | OMIM:615041 | |
Neural Tube Defects, Folate-Sensitive | Spinal dysraphism | OMIM:601634 | |
Spina Bifida-Hypospadias Syndrome | Spina bifida, Spinal dysraphism | ORPHA:3176 | |
Joubert Syndrome 15 | Exencephaly | OMIM:614464 | |
Anencephaly 1 | Anencephaly, Spina bifida | OMIM:206500 | |
Isolated Anencephaly/Exencephaly | Anencephaly | ORPHA:1048 | |
Craniorachischisis | Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism | ORPHA:63260 | |
Hypertelorism-Hypospadias-Polysyndactyly Syndrome | Encephalocele, Exencephaly | ORPHA:2211 | |
Oxoglutaric Aciduria | Abnormality of Krebs cycle metabolism, Hydrocephalus | ORPHA:31 | |
Sacral Defect With Anterior Meningocele | Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract | OMIM:600145 | |
Aprosencephaly Syndrome | Aprosencephaly, Anencephaly | OMIM:207770 | |
Combined Oxidative Phosphorylation Defect Type 29 | ORPHA:478029 | ||
Combined Oxidative Phosphorylation Deficiency 29 | OMIM:616811 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Txn2tm1(KOMP)Mbp | Reporter-tagged deletion allele (with selection cassette) | Targeting vectors, ES Cells |
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