The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
VIP of left eye
24 Images
XRay Images Forepaw
10 Images
VIP of right fundus
24 Images
VIP of right fundus
15 Images
XRay Images Whole Body Lateral Orientation
10 Images
VIP of left fundus
15 Images
XRay Images Skull Lateral Orientation
10 Images
XRay Images Skull Dorso Ventral Orientation
10 Images
VIP of right eye
15 Images
VIP of right eye
24 Images
VIP of left eye
15 Images
VIP of left fundus
24 Images
XRay Images Whole Body Dorso Ventral
10 Images
Waveform Image
1 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Pex14 by orthology or direct annotation.
| Disease | Similarity of phenotypes |
Matching phenotypes | Source |
|---|---|---|---|
| Neonatal Adrenoleukodystrophy | Cataract | ORPHA:44 | |
| Infantile Refsum Disease | Cataract | ORPHA:772 | |
| Zellweger Syndrome | Brushfield spots, Posterior embryotoxon, Corneal opacity, Cataract | ORPHA:912 | |
| Peroxisome Biogenesis Disorder 13A (Zellweger) | Posterior embryotoxon | OMIM:614887 |
The table below shows human diseases predicted to be associated to Pex14 by phenotypic similarity.
| Disease | Similarity of phenotypes |
Matching phenotypes | Source |
|---|---|---|---|
| Neonatal Adrenoleukodystrophy | Cataract | ORPHA:44 | |
| Infantile Refsum Disease | Cataract | ORPHA:772 | |
| Zellweger Syndrome | Brushfield spots, Posterior embryotoxon, Corneal opacity, Cataract | ORPHA:912 | |
| Peroxisome Biogenesis Disorder 13A (Zellweger) | Posterior embryotoxon | OMIM:614887 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| MGI Allele | Allele Type | Produced |
|---|---|---|
| Pex14tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
| Pex14em1(IMPC)Bay | Exon Deletion | Mice |
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