Gene: Tram2

Order

Name translocating chain-associating membrane protein 2

Synonyms C330003D03Rik

Status ES CellsMice
tm1a
phenotype data available

Links MGI:1924817    Ensembl Gene    Ensembl Orthologs    My Genes   

Viability Homozygous - Viable

Phenotype associations for Tram2

Significant     Not Significant     Not tested    
All Phenotypes Summary

Based on automated MP annotations supported by experiments on knockout mouse models. Click on icons to go to all Tram2 data for that phenotype.

Significant Phenotypes

System Phenotype Allele Zyg Sex Life Stage P Value Data
increased or absent threshold for auditory brainstem response Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 0.0
absent pinna reflex Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.52E-17
abnormal joint morphology Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 6.36E-16
abnormal scapula morphology Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 3.71E-15
decreased bone mineral content Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 5.49E-15
decreased bone mineral density Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 5.13E-13
decreased circulating insulin level Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.1E-8
abnormal radius morphology Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 2.33E-8
decreased lean body mass Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.39E-7
abnormal bone structure Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.52E-6
kyphosis Tram2tm1a(KOMP)Wtsi HOM Female postnatal 3.19E-6
abnormal ulna morphology Tram2tm1a(KOMP)Wtsi HOM Male postnatal 3.76E-6
decreased CD8-positive, alpha-beta T cell number Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 5.85E-6
increased circulating alkaline phosphatase level Tram2tm1a(KOMP)Wtsi HOM Female postnatal 1.09E-5
abnormal spine curvature Tram2tm1a(KOMP)Wtsi HOM Female postnatal 1.31E-5
increased grip strength Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.4E-5
decreased T cell number Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 1.86E-5
decreased circulating total protein level Tram2tm1a(KOMP)Wtsi HOM Female Male postnatal 6.79E-5

Download data as: TSV XLS



Expression

Secondary lacZ Expression Data
trunk (6)
  • Tram2tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    AORTA, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    LOWER URINARY TRACT, URINARY BLADDER, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    SMALL INTESTINE, HET, Male, WTSI

show all 6 images

nervous system (2)
  • Tram2tm1a(KOMP)Wtsi
    SPINAL CORD, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    BRAIN, HET, Male, WTSI
urinary system (2)
  • Tram2tm1a(KOMP)Wtsi
    LOWER URINARY TRACT, URINARY BLADDER, HET, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    KIDNEY, HET, Male, WTSI
cardiovascular system (1)
  • Tram2tm1a(KOMP)Wtsi
    AORTA, HET, Male, WTSI
digestive system (1)
  • Tram2tm1a(KOMP)Wtsi
    SMALL INTESTINE, HET, Male, WTSI
reproductive system (1)
  • Tram2tm1a(KOMP)Wtsi
    TESTIS, HET, Male, WTSI

Associated Images

Associated Images
  • X-ray: XRay Images Lateral Orientation
    27 Images
  • X-ray: XRay Images Forepaw
    14 Images
  • X-ray: XRay Images Dorso Ventral
    41 Images
  • X-ray: XRay Images Skull Dorso Ventral Orientation
    14 Images
  • X-ray: XRay Images Skull Lateral Orientation
    14 Images
Legacy Phenotype Associated Images
Xray (172)
  • Tram2tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    WT, Male, WTSI
  • Tram2tm1a(KOMP)Wtsi
    WT, Male, WTSI

show all 172 images

Histology Slide (2)
  • Tram2tm1a(KOMP)Wtsi
    HET, Female, WTSI
  • Tram2tm1a(KOMP)Wtsi
    HET, Female, WTSI

Disease Models

No associations by disease annotation and gene orthology found.

Order Mouse and ES Cells

Targeting Detail Product Ordering
MGI Allele Allele Type Type Map Seq Vector ES Cell Mouse Tissue Enquiry
Tram2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential)
Vector
Gene